IUBMB Enzyme Nomenclature


Accepted name: ABC-type Na+ transporter

Reaction: ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2]

Other name(s): natAB (gene names)

Systematic name: ATP phosphohydrolase (ABC-type, Na+-exporting)

Comments: ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This bacterial enzyme, characterized from Bacillus subtilis, exports Na+ ions out of the cell. cf. EC, Na+-transporting two-sector ATPase and EC, P-type Na+ transporter.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Cheng, J., Guffanti, A.A. and Krulwich, T.A. A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore. Mol. Microbiol. 23 (1997) 1107-1120. [PMID: 9106203]

2. Ogura, M., Tsukahara, K., Hayashi, K. and Tanaka, T. The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion. Microbiology 153 (2007) 667-675. [PMID: 17322186]

[EC created 2018]

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