IUBMB Enzyme Nomenclature


Accepted name: Na+-transporting two-sector ATPase

Reaction: ATP + H2O + n Na+[side 1] = ADP + phosphate + n Na+[side 2]

Other name(s): sodium-transporting two-sector ATPase; Na+-translocating ATPase; Na+-translocating FoF1-ATPase; sodium ion specific ATP synthase

Systematic name: ATP phosphohydrolase (two-sector, Na+-transporting)

Comments: A multisubunit ATPase transporter found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis. The enzyme is similar to EC (H+-transporting two-sector ATPase) but pumps Na+ rather than H+. By analogy to EC, it is likely that the enzyme pumps 4 sodium ions for every ATP molecule that is hydrolysed. cf. EC, P-type Na+ transporter and EC, ABC-type Na+ transporter.

Links to other databases: BRENDA, EXPASY, IUBMB, KEGG, MetaCyc, PDB, CAS Registry Number:


1. Solioz, M. and Davies, K. Operon of vacuolar-type Na+-ATPase of Enterococcus hirae. J. Biol. Chem. 269 (1994) 9453-9459. [PMID: 8144530]

2. Takase, K., Kakinuma, S., Yamato, I., Konishi, K., Igarashi, K. and Kanikuma, Y. Sequencing and characterization of the ntp gene cluster for vacuolar-type Na+-translocating ATPase of Enterococcus hirae. J. Biol. Chem. 269 (1994) 11037-11044. [PMID: 8157629]

3. Rahlfs, S. and Müller, V. Sequence of subunit c of the Na+-translocating F1Fo-ATPase of Acetobacterium woodii: proposal for determinants of Na+ specificity as revealed by sequence comparisons. FEBS Lett. 404 (1997) 269-271. [PMID: 9119076]

[EC created 2000 as EC, transferred 2018 to EC, modified 2018]

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