Oxo-acid dehydrogenase complexes

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© IUBMB 2003

Note 1: The acyl group on the dihydrolipoyl group of EC moves rapidly between S-8 and S-6, with more on S-8 at equilibrium.

Note 2: E1 (EC, EC or EC contains thiamine diphosphate

The N6-lipoyllysine residues of E2 (EC, EC and EC are the substrates reductively acylated by EC, EC, and EC respectively.

The overall reaction is:

R-CO-COO- + NAD+ + HS-CoA = R-CO-S-CoA + NADH + CO2

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citric acid cycle
EC pyruvate dehydrogenase (acetyl-transferring)
EC oxoglutarate dehydrogenase (succinyl-transferring)
EC 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
EC dihydrolipoyl dehydrogenase
EC dihydrolipoyllysine-residue acetyltransferase
EC dihydrolipoyllysine-residue succinyltransferase
EC dihydrolipoyllysine-residue (2-methylpropanoyl)transferase