New enzymes (February 2005, approved April 2005)An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.
New enzymes (February 2005, approved May 2005)
New enzymes (July 2005, approved September 2005)
New enzymes (September 2005, approved November 2005)
New bile acid enzymes (September 2005, approved November 2005)
New protein kinase enzymes (December 2005, approved February 2006)
Minor changes
*EC 1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
*EC 1.1.1.78 methylglyoxal reductase (NADH-dependent)
*EC 1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]
EC 1.1.1.283 methylglyoxal reductase (NADPH-dependent)
EC 1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase
EC 1.1.1.285 3"-deamino-3"-oxonicotianamine reductase
EC 1.1.1.286 isocitrate—homoisocitrate dehydrogenase
EC 1.1.1.287 D-arabinitol dehydrogenase (NADP+)
EC 1.1.1.288 xanthoxin dehydrogenase
EC 1.1.3.25 now included with EC 1.1.99.18
EC 1.2.1.1 deleted entry replaced by EC 1.1.1.284 and EC 4.4.1.22
EC 1.2.3.14 abscisic aldehyde oxidase
EC 1.2.7.9 deleted, identical to EC 1.2.7.3
*EC 1.3.1.3 δ4-3-oxosteroid 5β-reductase
EC 1.3.1.23 Deleted now EC 1.3.1.3
*EC 1.3.1.43 arogenate dehydrogenase
*EC 1.3.1.59 1,2-dihydroxy-3-methyl-1,2-dihydrobenzoate dehydrogenase
EC 1.3.1.78 arogenate dehydrogenase (NADP+)
EC 1.3.1.79 arogenate dehydrogenase [NAD(P)+]
EC 1.3.3.2 now EC 1.14.21.6
*EC 1.2.7.3 2-oxoglutarate synthase
EC 1.3.3.11 pyrroloquinoline-quinone synthase
EC 1.3.99.23 all-trans-retinol 13,14-reductase
EC 1.4.1.21 aspartate dehydrogenase
*EC 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
EC 1.5.7 With an iron-sulfur protein as acceptor
EC 1.5.7.1 methylenetetrahydrofolate reductase (ferredoxin)
EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)
EC 1.6.99.2 now EC 1.6.5.2
*EC 1.7.3.3 urate oxidase
EC 1.7.99.5 deleted entry now included with EC 1.5.1.20
*EC 1.8.1.14 CoA-disulfide reductase
EC 1.8.98.2 sulfiredoxin
EC 1.10.99.2 ribosyldihydronicotinamide dehydrogenase (quinone)
EC 1.10.99.3 violaxanthin de-epoxidase
EC 1.13.11.51 9-cis-epoxycarotenoid dioxygenase
EC 1.14.11.26 deacetoxycephalosporin-C hydroxylase
*EC 1.14.11.20 deacetoxyvindoline 4-hydroxylase
EC 1.14.11.24 2'-deoxymugineic-acid 2'-dioxygenase
EC 1.14.11.25 mugineic-acid 3-dioxygenase
EC 1.14.12.19 3-phenylpropionate dioxygenase
*EC 1.14.13.15 cholestanetriol 26-monooxygenase
*EC 1.14.13.53 4'-methoxyisoflavone 2'-hydroxylase
EC 1.14.13.89 isoflavone 2'-hydroxylase
EC 1.14.13.90 zeaxanthin epoxidase
EC 1.14.13.91 deoxysarpagine hydroxylase
EC 1.14.13.92 phenylacetone monooxygenase
EC 1.14.13.93 (+)-abscisic acid 8'-hydroxylase
EC 1.14.13.94 lithocholate 6β-hydroxylase
EC 1.14.13.95 7α-hydroxycholest-4-en-3-one 12α-hydroxylase
EC 1.14.13.96 5β-cholestane-3α,7α-diol 12α-hydroxylase
EC 1.14.13.97 taurochenodeoxycholate 6α-hydroxylase
EC 1.14.13.98 cholesterol 24-hydroxylase
EC 1.14.13.99 24-hydroxycholesterol 7α-hydroxylase
EC 1.14.13.100 25-hydroxycholesterol 7α-hydroxylase
EC 1.14.21.6 lathosterol oxidase
EC 1.14.99.38 cholesterol 25-hydroxylase
*EC 1.17.1.1 CDP-4-dehydro-6-deoxyglucose reductase
EC 1.17.1.6 bile-acid 7α-dehydroxylase
EC 1.17.99.3 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase
*EC 1.18.6.1 nitrogenase
*EC 2.1.1.34 tRNA guanosine-2'-O-methyltransferase
*EC 2.1.1.94 tabersonine 16-O-methyltransferase
*EC 2.1.1.99 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
*EC 2.1.1.110 sterigmatocystin 8-O-methyltransferase
EC 2.1.1.156 glycine/sarcosine N-methyltransferase
EC 2.1.1.157 sarcosine/dimethylglycine N-methyltransferase
EC 2.1.3.9 N-acetylornithine carbamoyltransferase
*EC 2.3.1.65 bile acid-CoA:amino acid N-acyltransferase
*EC 2.3.1.87 aralkylamine N-acetyltransferase
*EC 2.3.1.107 deacetylvindoline O-acetyltransferase
EC 2.3.1.174 3-oxoadipyl-CoA thiolase
EC 2.3.1.175 deacetylcephalosporin-C acetyltransferase
EC 2.3.1.176 propanoyl-CoA C-acyltransferase
*EC 2.4.1.46 monogalactosyldiacylglycerol synthase
EC 2.4.1.75 deleted entry
*EC 2.4.1.184 galactolipid galactosyltransferase
EC 2.4.1.233 deleted now EC 2.4.1.115
EC 2.4.1.241 digalactosyldiacylglycerol synthase
EC 2.4.1.242 NDP-glucose—starch glucosyltransferase
*EC 2.5.1.21 squalene synthase
*EC 2.5.1.32 phytoene synthase
*EC 2.6.1.21 D-amino acid transaminase
EC 2.6.1.78 aspartate—prephenate aminotransferase
EC 2.6.1.79 glutamate—prephenate aminotransferase
EC 2.6.1.80 nicotianamine aminotransferase
EC 2.7.1.37 now divided into EC 2.7.11.1, EC 2.7.11.8, EC 2.7.11.9, EC 2.7.11.10, EC 2.7.11.11, EC 2.7.11.12, EC 2.7.1.13, EC 2.7.11.21, EC 2.7.11.22, EC 2.7.11.24, EC 2.7.11.25, EC 2.7.11.30 and EC 2.7.12.1
EC 2.7.1.38 now EC 2.7.11.19
EC 2.7.1.99 now EC 2.7.11.2
EC 2.7.1.104 now EC 2.7.99.1
EC 2.7.1.109 now EC 2.7.11.31
EC 2.7.1.110 now EC 2.7.11.3
EC 2.7.1.112 now EC 2.7.10.1 and EC 2.7.10.2
EC 2.7.1.115 now EC 2.7.11.4
EC 2.7.1.116 now EC 2.7.11.5
EC 2.7.1.117 now EC 2.7.11.18
EC 2.7.1.120 now part of EC 2.7.11.17
EC 2.7.1.123 now part of EC 2.7.11.17
EC 2.7.1.124 now EC 2.7.11.6
EC 2.7.1.125 now EC 2.7.11.14
EC 2.7.1.126 now EC 2.7.11.15
EC 2.7.1.128 now EC 2.7.11.27
EC 2.7.1.129 now EC 2.7.11.7
EC 2.7.1.131 now EC 2.7.11.29
EC 2.7.1.132 now EC 2.7.11.28
EC 2.7.1.135 now EC 2.7.11.26
EC 2.7.1.141 now EC 2.7.11.23
EC 2.7.1.157 N-acetylgalactosamine kinase
EC 2.7.2.15 propionate kinase
EC 2.7.3.11 now EC 2.7.13.1
EC 2.7.3.12 now EC 2.7.13.2
EC 2.7.9.5 phosphoglucan, water dikinase
EC 2.7.10 Protein-tyrosine kinases
EC 2.7.10.1 receptor protein-tyrosine kinase
EC 2.7.10.2 non-specific protein-tyrosine kinase
EC 2.7.11 Protein-serine/threonine kinases
EC 2.7.11.1 non-specific serine/threonine protein kinase
EC 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase
EC 2.7.11.3 dephospho-[reductase kinase] kinase
EC 2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
EC 2.7.11.5 [isocitrate dehydrogenase (NADP+)] kinase
EC 2.7.11.6 [tyrosine 3-monooxygenase] kinase
EC 2.7.11.7 myosin-heavy-chain kinase
EC 2.7.11.8 Fas-activated serine/threonine kinase
EC 2.7.11.9 Goodpasture-antigen-binding protein kinase
EC 2.7.11.10 IκB kinase
EC 2.7.11.11 cAMP-dependent protein kinase
EC 2.7.11.12 cGMP-dependent protein kinase
EC 2.7.11.13 protein kinase C
EC 2.7.11.14 rhodopsin kinase
EC 2.7.11.15 β-adrenergic-receptor kinase
EC 2.7.11.16 G-protein-coupled receptor kinase
EC 2.7.11.17 Ca2+/calmodulin-dependent protein kinase
EC 2.7.11.18 myosin-light-chain kinase
EC 2.7.11.19 phosphorylase kinase
EC 2.7.11.20 elongation factor 2 kinase
EC 2.7.11.21 polo kinase
EC 2.7.11.22 cyclin-dependent kinase
EC 2.7.11.23 [RNA-polymerase]-subunit kinase
EC 2.7.11.24 mitogen-activated protein kinase
EC 2.7.11.25 mitogen-activated protein kinase kinase kinase
EC 2.7.11.26 tau-protein kinase
EC 2.7.11.27 [acetyl-CoA carboxylase] kinase
EC 2.7.11.28 tropomyosin kinase
EC 2.7.11.29 low-density-lipoprotein receptor kinase
EC 2.7.11.30 receptor protein serine/threonine kinase
EC 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
EC 2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
EC 2.7.12.1 dual-specificity kinase
EC 2.7.12.2 mitogen-activated protein kinase kinase
EC 2.7.13 Protein-histidine kinases
EC 2.7.13.1 protein-histidine pros-kinase
EC 2.7.13.2 protein-histidine tele-kinase
EC 2.7.13.3 histidine kinase
EC 2.7.99 Other protein kinases
EC 2.7.99.1 triphosphate—protein phosphotransferase
*EC 2.8.2.14 bile-salt sulfotransferase
EC 2.8.2.32 scymnol sulfotransferase
EC 2.8.2.33 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
EC 2.8.2.34 glycochenodeoxycholate sulfotransferase
*EC 3.1.1.76 poly(3-hydroxyoctanoate) depolymerase
EC 3.1.2.24 transferred entry now EC 3.13.1.3
EC 3.1.2.26 bile-acid-CoA hydrolase
EC 3.1.2.27 choloyl-CoA hydrolase
EC 3.2.1.152 mannosylglycoprotein endo-β-mannosidase
EC 3.2.1.153 fructan β-(2,1)-fructosidase
EC 3.2.1.154 fructan β-(2,6)-fructosidase
EC 3.2.1.156 oligosaccharide reducing-end xylanase
EC 3.4.21.104 mannan-binding lectin-associated serine protease-2
EC 3.4.21.105 rhomboid protease
*EC 3.5.1.48 acetylspermidine deacetylase
EC 3.5.1.91 N-substituted formamide deformylase
EC 3.5.1.92 pantetheine hydrolase
EC 3.5.1.93 glutaryl-7-aminocephalosporanic-acid acylase
EC 3.13.1.2 deleted probably EC 4.4.1.21
EC 3.13.1.3 2'-hydroxybiphenyl-2-sulfinate desulfinase
EC 4.1.1.82 phosphonopyruvate decarboxylase
EC 4.1.1.83 4-hydroxyphenylacetate decarboxylase
EC 4.1.1.84 D-dopachrome decarboxylase
EC 4.1.1.85 3-dehydro-L-gulonate-6-phosphate decarboxylase
*EC 4.2.1.91 arogenate dehydratase
EC 4.2.1.106 bile-acid 7α-dehydratase
EC 4.2.1.107 3α,7α,12αtrihydroxy-5β-cholest-24-enoyl-CoA dehydratase
EC 4.2.2.19 chondroitin B lyase
EC 4.2.99.19 transferred entry now EC 4.4.1.23
EC 4.4.1.22 S-(hydroxymethyl)glutathione synthase
EC 4.4.1.23 2-hydroxypropyl-CoM lyase
EC 4.99.1.7 phenylacetaldoxime dehydratase
*EC 5.1.3.4 L-ribulose-5-phosphate 4-epimerase
*EC 5.1.3.10 CDP-paratose 2-epimerase
EC 5.1.3.22 L-ribulose-5-phosphate 3-epimerase
EC 5.2.1.11 deleted entry
*EC 5.3.3.12 L-dopachrome isomerase
EC 5.3.99.8 capsanthin/capsorubin synthase
EC 5.3.99.9 neoxanthin synthase
*EC 6.2.1.7 cholate—CoA ligase
EC 6.2.1.29 deleted now EC 6.2.1.7
EC 6.3.1.11 glutamate—putrescine ligase
*EC 6.3.2.12 dihydrofolate synthase
*EC 6.3.2.17 tetrahydrofolate synthase