IUBMB Enzyme Nomenclature


Accepted name: GDP-polyphosphate phosphotransferase

Reaction: GTP + (phosphate)n = GDP + (phosphate)n+1

Other name(s): ppk2 (gene name); polyphosphate kinase 2

Systematic name: GTP:polyphosphate phosphotransferase

Comments: Polyphosphate kinase 2, characterized from the bacterium Pseudomonas aeruginosa, uses inorganic polyphosphate as a donor to convert GDP to GTP. The enzyme can also act on ADP (cf. EC, ATP-polyphosphate phosphotransferase), but with lower activity. The enzyme has only a trivial activity in the opposite direction (synthesizing polyphosphate from GTP). The GTP that is produced is believed to be consumed by EC, mannose-1-phosphate guanylyltransferase, for production of alginate during stationary phase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Zhang, H., Ishige, K. and Kornberg, A. A polyphosphate kinase (PPK2) widely conserved in bacteria. Proc. Natl. Acad. Sci. USA 99 (2002) 16678-16683. [PMID: 12486232]

2. Ishige, K., Zhang, H. and Kornberg, A. Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP. Proc. Natl. Acad. Sci. USA 99 (2002) 16684-16688. [PMID: 12482933]

[EC created 2021]

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