IUBMB Enzyme Nomenclature


Accepted name: kunzeaol synthase

Reaction: (2E,6E)-farnesyl diphosphate + H2O = kunzeaol + diphosphate

For diagram of reaction click here.

Glossary: kunzeaol = 6β-hydroxygermacra-1(10),4-diene = (1R,2E,6E,10R)-3,7-dimethyl-10-isopropylcyclodeca-2,6-dienol

Other name(s): TgTPS2 (gene name)

Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (kunzeaol forming)

Comments: Isolated from the root of the plant Thapsia garganica. The enzyme also produces germacrene D, bicyclogermacrene and traces of other sesquiterpenoids. See EC, (+)-germacrene D synthase and EC, bicyclogermacrene synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Pickel, B., Drew, D.P., Manczak, T., Weitzel, C., Simonsen, H.T. and Ro, D.K. Identification and characterization of a kunzeaol synthase from Thapsia garganica: implications for the biosynthesis of the pharmaceutical thapsigargin. Biochem. J. 448 (2012) 261-271. [PMID: 22938155]

[EC created 2013]

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