Symbolism and Terminology in Enzyme Kinetics

Prepared by the NC-IUB Panel on Enzyme Kinetics whose members were A. Cornish-Bowden (U.K., convener). H. B. F. Dixon (U.K.), K. J. Laidler (Canada), I. H. Segel (USA), J. Ricard (France), S. F. Velick (USA). and E. C. Webb (Australia).

The recommendations in this version are identical to the document published in Arch. Biochem. Biophys., 1983, 224, 732-740; Biochem. J., 1983, 213, 561-571; Eur. J. Biochem., 1982, 128, 281-291 (correction 1993, 213, 1); Biochemical Nomenclature and Related Documents, 2nd edition, Portland Press, 1992, pages 96-106. [Copyright IUBMB and IUPAC]. Any comments, corrections or suggestions for a future edition should be e-mailed to g.p.moss@qmul.ac.uk (Dr G P Moss)or other member of the Committees. In the World Wide Web version some errors which have been detected have been corrected and marked by , which is a link to details of the change and where it applies. For problems in converting the text into a World Wide Web version see the IUBMB Nomenclature home page.

• 1. Introduction
• 2. Basic definitions
  • 2.1 Rates of consumption and information
  • 2.2 Rate of reaction
  • 2.3 Elementary and composite reactions
• 3. Order of reaction and rate constant
  • 3.1 Numbering of reactions
  • 3.2 Steady-state hypothesis
• 4. Enzyme reactions involving a single substrate
  • 4.1 Limiting kinetics of enzyme-catalysed reactions
  • 4.2 Michaelis-Menten kinetics
  • 4.3 Non-Michaelis-Menten kinetics
• 5. Enzyme reactions involving more than one substrate
  • 5.1 Michaelis-Menten kinetics
  • 5.2 Michaelis-Menten kinetics of a two-substrate reaction
• 6. Inhibition
  • 6.1 Reversible and irreversible inhibition
  • 6.2 Linear and non-linear inhibition
  • 6.3 Degree of inhibition
  • 6.4 Classification of inhibition types
  • 6.5 Product inhibition
• 7. Activation
• 8. pH effects
• 9. Pre-steady-state kinetics
• 10. Non-Michaelis-Menten kinetics
• 11. Types of mechanism for enzymic catalysis
• 12. Enzyme activity
• 13. Summary of recommended symbols
• References
• Addendum 1. Rate of conversion
• Addendum 2. Rate of conversion Symbol

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