Reaction: ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate
For diagram of reaction click here.
Other name(s): ATP:(R)-MVA 3-phosphotransferase
Systematic name: ATP:(R)-mevalonate 3-phosphotransferase
Comments: Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 188.8.131.52) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 184.108.40.206, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
1. Vinokur, J.M., Korman, T.P., Cao, Z. and Bowie, J.U. Evidence of a novel mevalonate pathway in archaea. Biochemistry 53 (2014) 4161-4168. [PMID: 24914732]
2. Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T. and Hemmi, H. (R)-Mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum. J. Biol. Chem. 289 (2014) 15957-15967. [PMID: 24755225]