IUBMB Enzyme Nomenclature

EC 3.1.3.44

Accepted name: [acetyl-CoA carboxylase]-phosphatase

Reaction: [acetyl-CoA carboxylase] phosphate + H2O = [acetyl-CoA carboxylase] + phosphate

Systematic name: [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]-phosphate phosphohydrolase

Comments: Simultaneously dephosphorylates and activates EC 6.4.1.2 acetyl-CoA carboxylase. Acts similarly on EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase), EC 2.4.1.1 (phosphorylase), EC 2.4.1.11 [glycogen(starch) synthase], and dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate. Not identical to EC 3.1.3.17 ([phosphorylase] phosphatase ) or EC 3.1.3.43 {[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase}.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 77000-10-3

References:

1. Krakower, G.R. and Kim, K.-H. Purification and properties of acetyl-CoA carboxylase phosphatase. J. Biol. Chem. 256 (1980) 2408-2413.

[EC 3.1.3.44 created 1983]


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