Enzyme Nomenclature

EC 3.4 Acting on peptide bonds (Peptidases)

EC 3.4.1.1 now EC 3.4.11.1
EC 3.4.1.2 now EC 3.4.11.2
EC 3.4.1.3 now EC 3.4.11.4
EC 3.4.1.4 now EC 3.4.11.5
EC 3.4.2.1 now EC 3.4.17.1
EC 3.4.2.2 now EC 3.4.17.2
EC 3.4.2.3 now EC 3.4.17.4
EC 3.4.3.1 now EC 3.4.13.18
EC 3.4.3.2 now EC 3.4.13.18
EC 3.4.3.3 now EC 3.4.13.3
EC 3.4.3.4 now EC 3.4.13.5
EC 3.4.3.5 now EC 3.4.13.6
EC 3.4.3.6 now EC 3.4.13.8
EC 3.4.3.7 now EC 3.4.13.9
EC 3.4.4.1 now EC 3.4.23.1
EC 3.4.4.2 now EC 3.4.23.2
EC 3.4.4.3 now EC 3.4.23.4
EC 3.4.4.4 now EC 3.4.21.4
EC 3.4.4.5 now EC 3.4.21.1
EC 3.4.4.6 now EC 3.4.21.1
EC 3.4.4.7 now covered by EC 3.4.21.36, EC 3.4.21.37
EC 3.4.4.8 now EC 3.4.21.9
EC 3.4.4.9 now EC 3.4.14.1
EC 3.4.4.10 now EC 3.4.22.2
EC 3.4.4.11 now EC 3.4.22.6
EC 3.4.4.12 now EC 3.4.22.3
EC 3.4.4.13 now EC 3.4.21.5
EC 3.4.4.14 now EC 3.4.21.7
EC 3.4.4.15 now EC 3.4.23.15
EC 3.4.4.16 now covered by EC 3.4.21.62 to EC 3.4.21.67
EC 3.4.4.17 now covered by EC 3.4.23.20 to EC 3.4.23.30
EC 3.4.4.18 now EC 3.4.22.10
EC 3.4.4.19 now EC 3.4.24.3
EC 3.4.4.20 now EC 3.4.22.8
EC 3.4.4.21 now EC 3.4.21.34
EC 3.4.4.22 now EC 3.4.23.3
EC 3.4.4.23 now EC 3.4.23.5
EC 3.4.4.24 now covered by EC 3.4.22.32, EC 3.4.22.33
EC 3.4.4.25 deleted

EC 3.4.11 Aminopeptidases

EC 3.4.11.1 leucyl aminopeptidase
EC 3.4.11.2 membrane alanyl aminopeptidase
EC 3.4.11.3 cystinyl aminopeptidase
EC 3.4.11.4 tripeptide aminopeptidase
EC 3.4.11.5 prolyl aminopeptidase
EC 3.4.11.6 arginyl aminopeptidase
EC 3.4.11.7 glutamyl aminopeptidase
EC 3.4.11.8 now EC 3.4.19.3
EC 3.4.11.9 Xaa-Pro aminopeptidase
EC 3.4.11.10 bacterial leucyl aminopeptidase
EC 3.4.11.11 deleted
EC 3.4.11.12 deleted (supplement 4)
EC 3.4.11.13 clostridial aminopeptidase
EC 3.4.11.14 cytosol alanyl aminopeptidase
EC 3.4.11.15 lysyl aminopeptidase
EC 3.4.11.16 Xaa-Trp aminopeptidase
EC 3.4.11.17 tryptophanyl aminopeptidase
EC 3.4.11.18 methionyl aminopeptidase
EC 3.4.11.19 D-stereospecific aminopeptidase
EC 3.4.11.20 aminopeptidase Ey
EC 3.4.11.21 aspartyl aminopeptidase
EC 3.4.11.22 aminopeptidase I
EC 3.4.11.23 pepB aminopeptidase
EC 3.4.11.24 aminopeptidase S
EC 3.4.11.25 β-peptidyl aminopeptidase
EC 3.4.11.26 intermediate cleaving peptidase 55
EC 3.4.11.27 archaeal arginyl aminopeptidase

EC 3.4.12 Peptidylamino-Acid Hydrolases or Acylamino-Acid Hydrolases

EC 3.4.12.1 now EC 3.4.16.1
EC 3.4.12.2 now EC 3.4.17.1
EC 3.4.12.3 now EC 3.4.17.2
EC 3.4.12.4 now EC 3.4.16.2
EC 3.4.12.5 now EC 3.4.19.10
EC 3.4.12.6 now EC 3.4.17.8
EC 3.4.12.7 now EC 3.4.17.3
EC 3.4.12.8 now EC 3.4.17.4
EC 3.4.12.9 deleted
EC 3.4.12.10 now EC 3.4.19.9
EC 3.4.12.11 now EC 3.4.17.6
EC 3.4.12.12 now EC 3.4.16.1
EC 3.4.12.13 deleted

EC 3.4.13 Dipeptidases

EC 3.4.13.1 now EC 3.4.13.18
EC 3.4.13.2 now EC 3.4.13.18
EC 3.4.13.3 deleted, covered by EC 3.4.13.18 and EC 3.4.13.20
EC 3.4.13.4 Xaa-Arg dipeptidase
EC 3.4.13.5 Xaa-Methyl-His dipeptidase
EC 3.4.13.6 now EC 3.4.11.2 (supplement 4)
EC 3.4.13.7 Glu-Glu dipeptidase
EC 3.4.13.8 now EC 3.4.17.21 (supplement 6)
EC 3.4.13.9 Xaa-Pro dipeptidase
EC 3.4.13.10 now EC 3.4.19.5
EC 3.4.13.11 deleted, included in EC 3.4.13.18
EC 3.4.13.12 Met-Xaa dipeptidase
EC 3.4.13.13 deleted, included in EC 3.4.13.3
EC 3.4.13.14 deleted
EC 3.4.13.15 deleted, included in EC 3.4.13.18
EC 3.4.13.16 deleted
EC 3.4.13.17 non-stereospecific dipeptidase
EC 3.4.13.18 cytosol nonspecific dipeptidase
EC 3.4.13.19 membrane dipeptidase
EC 3.4.13.20 β-Ala-His dipeptidase
EC 3.4.13.21 dipeptidase E
EC 3.4.13.22 D-Ala-D-Ala dipeptidase
EC 3.4.13.23 cysteinylglycine-S-conjugate dipeptidase

EC 3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

EC 3.4.14.1 dipeptidyl-peptidase I
EC 3.4.14.2 dipeptidyl-peptidase II
EC 3.4.14.3 now EC 3.4.19.1
EC 3.4.14.4 dipeptidyl-peptidase III
EC 3.4.14.5 dipeptidyl-peptidase IV
EC 3.4.14.6 dipeptidyl-dipeptidase
EC 3.4.14.7 deleted
EC 3.4.14.8 now covered by EC 3.4.14.9, EC 3.4.14.10
EC 3.4.14.9 tripeptidyl-peptidase I
EC 3.4.14.10 tripeptidyl-peptidase II
EC 3.4.14.11 Xaa-Pro dipeptidyl-peptidase
EC 3.4.14.12 prolyltripeptidyl aminopeptidase
EC 3.4.14.13 γ-D-glutamyl-L-lysine dipeptidyl-peptidase
EC 3.4.14.14 [mycofactocin precursor peptide] peptidase

EC 3.4.15 Peptidyl-dipeptidases

EC 3.4.15.1 peptidyl-dipeptidase A
EC 3.4.15.2 now EC 3.4.19.2
EC 3.4.15.3 deleted, included in EC 3.4.15.5 (supplement 2)
EC 3.4.15.4 peptidyl-dipeptidase B
EC 3.4.15.5 peptidyl-dipeptidase Dcp
EC 3.4.15.6 cyanophycinase

EC 3.4.16 Serine-type carboxypeptidases

EC 3.4.16.1 deleted, included in EC 3.4.16.5, EC 3.4.16.6 (supplement 1)
EC 3.4.16.2 lysosomal Pro-Xaa carboxypeptidase
EC 3.4.16.3 deleted, included in EC 3.4.16.5 (supplement 1)
EC 3.4.16.4 serine-type D-Ala-D-Ala carboxypeptidase
EC 3.4.16.5 carboxypeptidase C
EC 3.4.16.6 carboxypeptidase D

EC 3.4.17 Metallocarboxypeptidases

EC 3.4.17.1 carboxypeptidase A
EC 3.4.17.2 carboxypeptidase B
EC 3.4.17.3 lysine carboxypeptidase
EC 3.4.17.4 Gly-Xaa carboxypeptidase
EC 3.4.17.5 deleted
EC 3.4.17.6 alanine carboxypeptidase
EC 3.4.17.7 now EC 3.4.19.10
EC 3.4.17.8 muramoylpentapeptide carboxypeptidase
EC 3.4.17.9 deleted, included in EC 3.4.17.4
EC 3.4.17.10 carboxypeptidase E
EC 3.4.17.11 glutamate carboxypeptidase
EC 3.4.17.12 carboxypeptidase M
EC 3.4.17.13 muramoyltetrapeptide carboxypeptidase
EC 3.4.17.14 zinc D-Ala-D-Ala carboxypeptidase
EC 3.4.17.15 carboxypeptidase A2
EC 3.4.17.16 membrane Pro-Xaa carboxypeptidase
EC 3.4.17.17 tubulinyl-Tyr carboxypeptidase
EC 3.4.17.18 carboxypeptidase T
EC 3.4.17.19 carboxypeptidase Taq
EC 3.4.17.20 carboxypeptidase U
EC 3.4.17.21 glutamate carboxypeptidase II
EC 3.4.17.22 metallocarboxypeptidase D
EC 3.4.17.23 angiotensin-converting enzyme 2
EC 3.4.17.24 tubulin-glutamate carboxypeptidase
EC 3.4.17.25 glutathione-S-conjugate glycine hydrolase

EC 3.4.18 Cysteine-type carboxypeptidases

EC 3.4.18.1 cathepsin X

EC 3.4.19 Omega peptidases

EC 3.4.19.1 acylaminoacyl-peptidase
EC 3.4.19.2 peptidyl-glycinamidase
EC 3.4.19.3 pyroglutamyl-peptidase I
EC 3.4.19.4 deleted
EC 3.4.19.5 β-aspartyl-peptidase
EC 3.4.19.6 pyroglutamyl-peptidase II
EC 3.4.19.7 N-formylmethionyl-peptidase
EC 3.4.19.8 now EC 3.4.17.21 (supplement 6)
EC 3.4.19.9 folate γ-glutamyl hydrolase
EC 3.4.19.10 now EC 3.5.1.28 (supplement 4)
EC 3.4.19.11 γ-D-Glutamyl-meso-diaminopimelate peptidase I
EC 3.4.19.12 ubiquitinyl hydrolase 1
EC 3.4.19.13 glutathione γ-glutamate hydrolase
EC 3.4.19.14 leukotriene-C₄ hydrolase
EC 3.4.19.15 desampylase
EC 3.4.19.16 glucosinolate γ-glutamyl hydrolase

EC 3.4.21 Serine endopeptidases

EC 3.4.21.1 chymotrypsin
EC 3.4.21.2 chymotrypsin C
EC 3.4.21.3 metridin
EC 3.4.21.4 trypsin
EC 3.4.21.5 thrombin
EC 3.4.21.6 coagulation Factor Xa
EC 3.4.21.7 plasmin
EC 3.4.21.8 now covered by EC 3.4.21.34, EC 3.4.21.35
EC 3.4.21.9 enteropeptidase
EC 3.4.21.10 acrosin
EC 3.4.21.11 now covered by EC 3.4.21.36, EC 3.4.21.37
EC 3.4.21.12 α-Lytic endopeptidase
EC 3.4.21.13 now EC 3.4.16.1
EC 3.4.21.14 now covered by EC 3.4.21.62 to EC 3.4.21.65, EC 3.4.21.67
EC 3.4.21.15 now EC 3.4.21.63
EC 3.4.21.16 deleted
EC 3.4.21.17 deleted
EC 3.4.21.18 deleted
EC 3.4.21.19 glutamyl endopeptidase
EC 3.4.21.20 cathepsin G
EC 3.4.21.21 coagulation Factor VIIa
EC 3.4.21.22 coagulation Factor IXa
EC 3.4.21.23 deleted
EC 3.4.21.24 deleted
EC 3.4.21.25 cucumisin
EC 3.4.21.26 prolyl oligopeptidase
EC 3.4.21.27 coagulation Factor XIa
EC 3.4.21.28 deleted, included in EC 3.4.21.74
EC 3.4.21.29 deleted, included in EC 3.4.21.74
EC 3.4.21.30 deleted, included in EC 3.4.21.74
EC 3.4.21.31 now covered by EC 3.4.21.68, EC 3.4.21.73
EC 3.4.21.32 brachyurin
EC 3.4.21.33 deleted
EC 3.4.21.34 plasma kallikrein
EC 3.4.21.35 tissue kallikrein
EC 3.4.21.36 pancreatic elastase
EC 3.4.21.37 leukocyte elastase
EC 3.4.21.38 coagulation Factor XIIa
EC 3.4.21.39 chymase
EC 3.4.21.40 deleted
EC 3.4.21.41 complement subcomponent C
EC 3.4.21.42 complement subcomponent C
EC 3.4.21.43 classical-complement-pathway C3/C5 convertase
EC 3.4.21.44 deleted, included in EC 3.4.21.43
EC 3.4.21.45 complement Factor I
EC 3.4.21.46 complement Factor D
EC 3.4.21.47 alternative-complement-pathway C3/C5 convertase
EC 3.4.21.48 cerevisin
EC 3.4.21.49 hypodermin C
EC 3.4.21.50 lysyl endopeptidase
EC 3.4.21.51 deleted
EC 3.4.21.52 deleted
EC 3.4.21.53 endopeptidase La
EC 3.4.21.54 γ-renin
EC 3.4.21.55 Venombin AB
EC 3.4.21.56 deleted
EC 3.4.21.57 leucyl endopeptidase
EC 3.4.21.58 deleted
EC 3.4.21.59 tryptase
EC 3.4.21.60 scutelarin
EC 3.4.21.61 kexin
EC 3.4.21.62 subtilisin
EC 3.4.21.63 oryzin
EC 3.4.21.64 peptidase K
EC 3.4.21.65 thermomycolin
EC 3.4.21.66 thermitase
EC 3.4.21.67 endopeptidase So
EC 3.4.21.68 t-plasminogen activator
EC 3.4.21.69 protein C (activated)
EC 3.4.21.70 pancreatic endopeptidase E
EC 3.4.21.71 pancreatic elastase II
EC 3.4.21.72 IgA-specific serine endopeptidase
EC 3.4.21.73 u-plasminogen activator
EC 3.4.21.74 venombin A
EC 3.4.21.75 furin
EC 3.4.21.76 myeloblastin
EC 3.4.21.77 semenogelase
EC 3.4.21.78 granzyme A
EC 3.4.21.79 granzyme B
EC 3.4.21.80 streptogrisin A
EC 3.4.21.81 streptogrisin B
EC 3.4.21.82 glutamyl endopeptidase II
EC 3.4.21.83 oligopeptidase B
EC 3.4.21.84 limulus clotting factor
EC 3.4.21.85 limulus clotting factor
EC 3.4.21.86 limulus clotting enzyme
EC 3.4.21.87 now EC 3.4.23.49
EC 3.4.21.88 repressor LexA
EC 3.4.21.89 signal peptidase I
EC 3.4.21.90 togavirin
EC 3.4.21.91 flavivirin
EC 3.4.21.92 endopeptidase Clp
EC 3.4.21.93 proprotein convertase 1
EC 3.4.21.94 proprotein convertase 2
EC 3.4.21.95 snake venom factor V activator
EC 3.4.21.96 lactocepin
EC 3.4.21.97 assemblin
EC 3.4.21.98 hepacivirin
EC 3.4.21.99 spermosin
EC 3.4.21.100 sedolisin
EC 3.4.21.101 xanthomonalisin
EC 3.4.21.102 C-terminal processing peptidase
EC 3.4.21.103 physarolisin
EC 3.4.21.104 mannan-binding lectin-associated serine protease-2
EC 3.4.21.105 rhomboid protease
EC 3.4.21.106 hepsin
EC 3.4.21.107 peptidase Do
EC 3.4.21.108 HtrA2 peptidase
EC 3.4.21.109 matriptase
EC 3.4.21.110 C5a peptidase
EC 3.4.21.111 aqualysin 1
EC 3.4.21.112 site-1 protease
EC 3.4.21.113 pestivirus NS3 polyprotein peptidase
EC 3.4.21.114 equine arterivirus serine peptidase
EC 3.4.21.115 infectious pancreatic necrosis birnavirus Vp4 peptidase
EC 3.4.21.116 SpoIVB peptidase
EC 3.4.21.117 stratum corneum chymotryptic enzyme
EC 3.4.21.118 kallikrein 8
EC 3.4.21.119 kallikrein 13
EC 3.4.21.120 oviductin
EC 3.4.21.121 Lys-Lys/Arg-Xaa endopeptidase
EC 3.4.21.122 transmembrane protease serine 2
EC 3.4.21.123 kumamolysin

EC 3.4.22 Cysteine endopeptidases

EC 3.4.22.1 cathepsin B
EC 3.4.22.2 papain
EC 3.4.22.3 ficain
EC 3.4.22.4 now covered by EC 3.4.22.32, EC 3.4.22.33
EC 3.4.22.5 now EC 3.4.22.33
EC 3.4.22.6 chymopapain
EC 3.4.22.7 asclepain
EC 3.4.22.8 clostripain
EC 3.4.22.9 now EC 3.4.21.48
EC 3.4.22.10 streptopain
EC 3.4.22.11 now EC 3.4.24.56 (supplement 3)
EC 3.4.22.12 now EC 3.4.19.9
EC 3.4.22.13 deleted
EC 3.4.22.14 actinidain
EC 3.4.22.15 cathepsin L
EC 3.4.22.16 cathepsin H
EC 3.4.22.17 now EC 3.4.22.52 and EC 3.4.22.53
EC 3.4.22.18 deleted, included in EC 3.4.21.26
EC 3.4.22.19 deleted, included in EC 3.4.24.15
EC 3.4.22.20 deleted
EC 3.4.22.21 deleted, included in EC 3.4.99.46
EC 3.4.22.22 now EC 3.4.24.37
EC 3.4.22.23 deleted, included in EC 3.4.21.61
EC 3.4.22.24 cathepsin T
EC 3.4.22.25 glycyl endopeptidase
EC 3.4.22.26 cancer procoagulant
EC 3.4.22.27 cathepsin S
EC 3.4.22.28 picornain 3C
EC 3.4.22.29 picornain 2A
EC 3.4.22.30 caricain
EC 3.4.22.31 ananain
EC 3.4.22.32 stem bromelain
EC 3.4.22.33 fruit bromelain
EC 3.4.22.34 legumain
EC 3.4.22.35 histolysain
EC 3.4.22.36 caspase-1
EC 3.4.22.37 gingipain R
EC 3.4.22.38 cathepsin K
EC 3.4.22.39 adenain
EC 3.4.22.40 bleomycin hydrolase
EC 3.4.22.41 cathepsin F
EC 3.4.22.42 cathepsin O
EC 3.4.22.43 cathepsin V
EC 3.4.22.44 nuclear-inclusion-a endopeptidase
EC 3.4.22.45 helper-component proteinase
EC 3.4.22.46 L-peptidase
EC 3.4.22.47 gingipain K
EC 3.4.22.48 staphopain
EC 3.4.22.49 separase
EC 3.4.22.50 V-cath endopeptidase
EC 3.4.22.51 cruzipain
EC 3.4.22.52 calpain-1
EC 3.4.22.53 calpain-2
EC 3.4.22.54 calpain-3
EC 3.4.22.55 caspase-2
EC 3.4.22.56 caspase-3
EC 3.4.22.57 caspase-4
EC 3.4.22.58 caspase-5
EC 3.4.22.59 caspase-6
EC 3.4.22.60 caspase-7
EC 3.4.22.61 caspase-8
EC 3.4.22.62 caspase-9
EC 3.4.22.63 caspase-10
EC 3.4.22.64 caspase-11
EC 3.4.22.65 peptidase 1 (mite)
EC 3.4.22.66 calicivirin
EC 3.4.22.67 zingipain
EC 3.4.22.68 Ulp1 peptidase
EC 3.4.22.69 SARS coronavirus main proteinase
EC 3.4.22.70 sortase A
EC 3.4.22.71 sortase B

EC 3.4.23 Aspartic endopeptidases

EC 3.4.23.1 pepsin A
EC 3.4.23.2 pepsin B
EC 3.4.23.3 gastricsin
EC 3.4.23.4 chymosin
EC 3.4.23.5 cathepsin D
EC 3.4.23.6 now covered by EC 3.4.23.18 to EC 3.4.23.28, EC 3.4.23.30
EC 3.4.23.7 now EC 3.4.24.20
EC 3.4.23.8 now EC 3.4.24.25
EC 3.4.23.9 now EC 3.4.24.21
EC 3.4.23.10 now EC 3.4.24.22
EC 3.4.23.11 deleted
EC 3.4.23.12 nepenthesin
EC 3.4.23.13 deleted
EC 3.4.23.14 deleted
EC 3.4.23.15 renin
EC 3.4.23.16 HIV-1 retropepsin
EC 3.4.23.17 Pro-opiomelanocortin converting enzyme
EC 3.4.23.18 aspergillopepsin I
EC 3.4.23.19 aspergillopepsin II
EC 3.4.23.20 penicillopepsin
EC 3.4.23.21 rhizopuspepsin
EC 3.4.23.22 endothiapepsin
EC 3.4.23.23 mucorpepsin
EC 3.4.23.24 candidapepsin
EC 3.4.23.25 Saccharopepsin
EC 3.4.23.26 rhodotorulapepsin
EC 3.4.23.27 now EC 3.4.21.103
EC 3.4.23.28 acrocylindropepsin
EC 3.4.23.29 polyporopepsin
EC 3.4.23.30 pycnoporopepsin
EC 3.4.23.31 scytalidopepsin A
EC 3.4.23.32 scytalidopepsin B
EC 3.4.23.33 now EC 3.4.21.101
EC 3.4.23.34 cathepsin E
EC 3.4.23.35 barrierpepsin
EC 3.4.23.36 signal peptidase II
EC 3.4.23.37 now EC 3.4.21.100
EC 3.4.23.38 plasmepsin I
EC 3.4.23.39 plasmepsin II
EC 3.4.23.40 phytepsin
EC 3.4.23.41 yapsin 1
EC 3.4.23.42 thermopsin
EC 3.4.23.43 prepilin peptidase
EC 3.4.23.44 nodavirus endopeptidase
EC 3.4.23.45 memapsin 1
EC 3.4.23.46 memapsin 2
EC 3.4.23.47 HIV-2 retropepsin
EC 3.4.23.48 plasminogen activator Pla
EC 3.4.23.49 omptin
EC 3.4.23.50 human endogenous retrovirus K endopeptidase
EC 3.4.23.51 HycI peptidase
EC 3.4.23.52 preflagellin peptidase

EC 3.4.24 Metalloendopeptidases

EC 3.4.24.1 atrolysin A
EC 3.4.24.2 deleted
EC 3.4.24.3 microbial collagenase
EC 3.4.24.4 now covered by EC 3.4.24.25 to EC 3.4.24.32, EC 3.4.24.39, EC 3.4.24.40
EC 3.4.24.5 now covered by EC 3.4.22.17, EC 3.4.25.1
EC 3.4.24.6 leucolysin
EC 3.4.24.7 interstitial collagenase
EC 3.4.24.8 deleted, included in EC 3.4.24.3
EC 3.4.24.9 deleted
EC 3.4.24.10 deleted
EC 3.4.24.11 neprilysin
EC 3.4.24.12 envelysin
EC 3.4.24.13 IgA-specific metalloendopeptidase
EC 3.4.24.14 procollagen N-endopeptidase
EC 3.4.24.15 thimet oligopeptidase
EC 3.4.24.16 neurolysin
EC 3.4.24.17 stromelysin 1
EC 3.4.24.18 meprin A
EC 3.4.24.19 procollagen C-endopeptidase
EC 3.4.24.20 peptidyl-Lys metalloendopeptidase
EC 3.4.24.21 astacin
EC 3.4.24.22 stromelysin 2
EC 3.4.24.23 matrilysin
EC 3.4.24.24 gelatinase A
EC 3.4.24.25 vibriolysin
EC 3.4.24.26 pseudolysin
EC 3.4.24.27 thermolysin
EC 3.4.24.28 bacillolysin
EC 3.4.24.29 aureolysin
EC 3.4.24.30 coccolysin
EC 3.4.24.31 mycolysin
EC 3.4.24.32 β-lytic metalloendopeptidase
EC 3.4.24.33 peptidyl-Asp metalloendopeptidase
EC 3.4.24.34 neutrophil collagenase
EC 3.4.24.35 gelatinase B
EC 3.4.24.36 leishmanolysin
EC 3.4.24.37 saccharolysin
EC 3.4.24.38 gametolysin
EC 3.4.24.39 deuterolysin
EC 3.4.24.40 serralysin
EC 3.4.24.41 atrolysin B
EC 3.4.24.42 atrolysin C
EC 3.4.24.43 atroxase
EC 3.4.24.44 atrolysin E
EC 3.4.24.45 atrolysin F
EC 3.4.24.46 adamalysin
EC 3.4.24.47 horrilysin
EC 3.4.24.48 ruberlysin
EC 3.4.24.49 bothropasin
EC 3.4.24.50 bothrolysin
EC 3.4.24.51 ophiolysin
EC 3.4.24.52 trimerelysin I
EC 3.4.24.53 trimerelysin II
EC 3.4.24.54 mucrolysin
EC 3.4.24.55 pitrilysin
EC 3.4.24.56 insulysin
EC 3.4.24.57 O-sialoglycoprotein endopeptidase
EC 3.4.24.58 Russellysin
EC 3.4.24.59 mitochondrial intermediate peptidase
EC 3.4.24.60 dactylysin
EC 3.4.24.61 nardilysin
EC 3.4.24.62 magnolysin
EC 3.4.24.63 meprin B
EC 3.4.24.64 mitochondrial processing peptidase
EC 3.4.24.65 macrophage elastase
EC 3.4.24.66 choriolysin L
EC 3.4.24.67 choriolysin H
EC 3.4.24.68 tentoxilysin
EC 3.4.24.69 bontoxilysin
EC 3.4.24.70 oligopeptidase A
EC 3.4.24.71 endothelin-converting enzyme
EC 3.4.24.72 fibrolase
EC 3.4.24.73 jararhagin
EC 3.4.24.74 fragilysin
EC 3.4.24.75 lysostaphin
EC 3.4.24.76 flavastacin
EC 3.4.24.77 snapalysin
EC 3.4.24.78 gpr endopeptidase
EC 3.4.24.79 pappalysin-1
EC 3.4.24.80 membrane-type matrix metalloproteinase-1
EC 3.4.24.81 ADAM10 endopeptidase
EC 3.4.24.82 ADAMTS-4 endopeptidase
EC 3.4.24.83 anthrax lethal factor endopeptidase
EC 3.4.24.84 Ste24 endopeptidase
EC 3.4.24.85 S2P endopeptidase
EC 3.4.24.86 ADAM 17 endopeptidase
EC 3.4.24.87 ADAMTS13 endopeptidase
EC 3.4.24.88 now EC 3.4.19.15
EC 3.4.24.89 Pro-Pro endopeptidase

EC 3.4.25 Threonine endopeptidases

EC 3.4.25.1 proteasome endopeptidase complex
EC 3.4.25.2 HslU—HslV peptidase

EC 3.4.26 Glutamic endopeptidases
EC 3.4.26.1 intramembrane prenyl-peptidase Rce1
EC 3.4.26.2 scytalidoglutamic peptidase
EC 3.4.99 Endopeptidases of unknown catalytic mechanism

EC 3.4.99.1 now EC 3.4.23.28
EC 3.4.99.2 deleted
EC 3.4.99.3 deleted
EC 3.4.99.4 now EC 3.4.23.12
EC 3.4.99.5 now EC 3.4.24.3
EC 3.4.99.6 now EC 3.4.24.21
EC 3.4.99.7 deleted
EC 3.4.99.8 deleted
EC 3.4.99.9 deleted
EC 3.4.99.10 now EC 3.4.24.56 (supplement 3)
EC 3.4.99.11 deleted
EC 3.4.99.12 deleted
EC 3.4.99.13 now EC 3.4.24.32
EC 3.4.99.14 deleted
EC 3.4.99.15 deleted
EC 3.4.99.16 deleted
EC 3.4.99.17 deleted
EC 3.4.99.18 deleted
EC 3.4.99.19 now EC 3.4.23.15
EC 3.4.99.20 deleted
EC 3.4.99.21 deleted
EC 3.4.99.22 now EC 3.4.24.29
EC 3.4.99.23 deleted
EC 3.4.99.24 deleted
EC 3.4.99.25 deleted, included in EC 3.4.23.21
EC 3.4.99.26 now covered by EC 3.4.24.73, EC 3.4.21.68
EC 3.4.99.27 deleted
EC 3.4.99.28 now EC 3.4.21.60
EC 3.4.99.29 deleted
EC 3.4.99.30 deleted, included in EC 3.4.24.20
EC 3.4.99.31 deleted, included in EC 3.4.24.15
EC 3.4.99.32 now EC 3.4.24.20
EC 3.4.99.33 deleted
EC 3.4.99.34 deleted
EC 3.4.99.35 now EC 3.4.23.36 (supplement 2)
EC 3.4.99.36 now EC 3.4.21.89 (supplement 2)
EC 3.4.99.37 deleted
EC 3.4.99.38 now EC 3.4.23.17
EC 3.4.99.39 deleted
EC 3.4.99.40 deleted
EC 3.4.99.41 now EC 3.4.24.64 (supplement 2)
EC 3.4.99.42 deleted
EC 3.4.99.43 now EC 3.4.23.42 (supplement 6)
EC 3.4.99.44 now EC 3.4.24.55 (supplement 1)
EC 3.4.99.45 now EC 3.4.24.56 (supplement 1)
EC 3.4.99.46 now EC 3.4.25.1 (supplement 6)

EC 3.5 Acting on Carbon-Nitrogen Bonds, other than Peptide Bonds

EC 3.5.1 In Linear Amides

EC 3.5.1.1 asparaginase
EC 3.5.1.2 glutaminase
EC 3.5.1.3 ω-amidase
EC 3.5.1.4 amidase
EC 3.5.1.5 urease
EC 3.5.1.6 β-ureidopropionase
EC 3.5.1.7 ureidosuccinase
EC 3.5.1.8 formylaspartate deformylase
EC 3.5.1.9 arylformamidase
EC 3.5.1.10 formyltetrahydrofolate deformylase
EC 3.5.1.11 penicillin amidase
EC 3.5.1.12 biotinidase
EC 3.5.1.13 aryl-acylamidase
EC 3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase
EC 3.5.1.15 aspartoacylase
EC 3.5.1.16 acetylornithine deacetylase
EC 3.5.1.17 acyl-lysine deacylase
EC 3.5.1.18 succinyl-diaminopimelate desuccinylase
EC 3.5.1.19 nicotinamidase
EC 3.5.1.20 citrullinase
EC 3.5.1.21 N-acetyl-β-alanine deacetylase
EC 3.5.1.22 pantothenase
EC 3.5.1.23 ceramidase
EC 3.5.1.24 choloylglycine hydrolase
EC 3.5.1.25 N-acetylglucosamine-6-phosphate deacetylase
EC 3.5.1.26 N⁴-(β-N-acetylglucosaminyl)-L-asparaginase
EC 3.5.1.27 deleted, covered by EC 3.5.1.88
EC 3.5.1.28 N-acetylmuramoyl-L-alanine amidase
EC 3.5.1.29 2-(acetamidomethylene)succinate hydrolase
EC 3.5.1.30 5-aminopentanamidase
EC 3.5.1.31 formylmethionine deformylase
EC 3.5.1.32 hippurate hydrolase
EC 3.5.1.33 N-acetylglucosamine deacetylase
EC 3.5.1.34 deleted, same as EC 3.4.13.5
EC 3.5.1.35 D-glutaminase
EC 3.5.1.36 N-methyl-2-oxoglutaramate hydrolase
EC 3.5.1.37 deleted, same as EC 3.5.1.26
EC 3.5.1.38 glutamin-(asparagin-)ase
EC 3.5.1.39 alkylamidase
EC 3.5.1.40 acylagmatine amidase
EC 3.5.1.41 chitin deacetylase
EC 3.5.1.42 nicotinamide-nucleotide amidase
EC 3.5.1.43 peptidyl-glutaminase
EC 3.5.1.44 protein-glutamine glutaminase
EC 3.5.1.45 now EC 6.3.4.6
EC 3.5.1.46 6-aminohexanoate-oligomer exohydrolase
EC 3.5.1.47 N-acetyldiaminopimelate deacetylase
EC 3.5.1.48 acetylspermidine deacetylase
EC 3.5.1.49 formamidase
EC 3.5.1.50 pentanamidase
EC 3.5.1.51 4-acetamidobutyryl-CoA deacetylase
EC 3.5.1.52 peptide-N⁴-(N-acetyl-β-glucosaminyl)asparagine amidase
EC 3.5.1.53 N-carbamoylputrescine amidase
EC 3.5.1.54 allophanate hydrolase
EC 3.5.1.55 long-chain-fatty-acyl-glutamate deacylase
EC 3.5.1.56 N,N-dimethylformamidase
EC 3.5.1.57 tryptophanamidase
EC 3.5.1.58 N-benzyloxycarbonylglycine hydrolase
EC 3.5.1.59 N-carbamoylsarcosine amidase
EC 3.5.1.60 N-(long-chain-acyl)ethanolamine deacylase
EC 3.5.1.61 transferred now EC 4.3.3.8
EC 3.5.1.62 acetylputrescine deacetylase
EC 3.5.1.63 4-acetamidobutyrate deacetylase
EC 3.5.1.64 N^α-benzyloxycarbonylleucine hydrolase
EC 3.5.1.65 theanine hydrolase
EC 3.5.1.66 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
EC 3.5.1.67 4-methyleneglutaminase
EC 3.5.1.68 N-formylglutamate deformylase
EC 3.5.1.69 glycosphingolipid deacylase
EC 3.5.1.70 aculeacin-A deacylase
EC 3.5.1.71 N-feruloylglycine deacylase
EC 3.5.1.72 D-benzoylarginine-4-nitroanilide amidase
EC 3.5.1.73 carnitinamidase
EC 3.5.1.74 chenodeoxycholoyltaurine hydrolase
EC 3.5.1.75 urethanase
EC 3.5.1.76 arylalkyl acylamidase
EC 3.5.1.77 N-carbamoyl-D-amino acid hydrolase
EC 3.5.1.78 glutathionylspermidine amidase
EC 3.5.1.79 phthalyl amidase
EC 3.5.1.80 deleted, identical to EC 3.5.1.25
EC 3.5.1.81 N-acyl-D-amino-acid deacylase
EC 3.5.1.82 N-acyl-D-glutamate deacylase
EC 3.5.1.83 N-acyl-D-aspartate deacylase
EC 3.5.1.84 biuret amidohydrolase
EC 3.5.1.85 (S)-N-acetyl-1-phenylethylamine hydrolase
EC 3.5.1.86 mandelamide amidase
EC 3.5.1.87 N-carbamoyl-L-amino-acid hydrolase
EC 3.5.1.88 peptide deformylase
EC 3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase
EC 3.5.1.90 adenosylcobinamide hydrolase
EC 3.5.1.91 N-substituted formamide deformylase
EC 3.5.1.92 pantetheine hydrolase
EC 3.5.1.93 glutaryl-7-aminocephalosporanic-acid acylase
EC 3.5.1.94 γ-glutamyl-γ-aminobutyrate hydrolase
EC 3.5.1.95 N-malonylurea hydrolase
EC 3.5.1.96 succinylglutamate desuccinylase
EC 3.5.1.97 acyl-homoserine-lactone acylase
EC 3.5.1.98 histone deacetylase
EC 3.5.1.99 fatty acid amide hydrolase
EC 3.5.1.100 (R)-amidase
EC 3.5.1.101 L-proline amide hydrolase
EC 3.5.1.102 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
EC 3.5.1.103 N-acetyl-1D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase
EC 3.5.1.104 peptidoglycan-N-acetylglucosamine deacetylase
EC 3.5.1.105 chitin disaccharide deacetylase
EC 3.5.1.106 N-formylmaleamate deformylase
EC 3.5.1.107 maleamate amidohydrolase
EC 3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase
EC 3.5.1.109 sphingomyelin deacylase
EC 3.5.1.110 ureidoacrylate amidohydrolase
EC 3.5.1.111 2-oxoglutaramate amidase
EC 3.5.1.112 2'-N-acetylparomamine deacetylase
EC 3.5.1.113 2'''-acetyl-6'''-hydroxyneomycin C deacetylase
EC 3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase
EC 3.5.1.115 mycothiol S-conjugate amidase
EC 3.5.1.116 ureidoglycolate amidohydrolase
EC 3.5.1.117 6-aminohexanoate-oligomer endohydrolase
EC 3.5.1.118 γ-glutamyl hercynylcysteine S-oxide hydrolase
EC 3.5.1.119 Pup deamidase
EC 3.5.1.120 transferred, now EC 3.5.99.11
EC 3.5.1.121 protein N-terminal asparagine amidohydrolase
EC 3.5.1.122 protein N-terminal glutamine amidohydrolase
EC 3.5.1.123 γ-glutamylanilide hydrolase
EC 3.5.1.124 protein deglycase
EC 3.5.1.125 N²-acetyl-L-2,4-diaminobutanoate deacetylase
EC 3.5.1.126 oxamate amidohydrolase
EC 3.5.1.127 jasmonoyl-L-amino acid hydrolase
EC 3.5.1.128 deaminated glutathione amidase
EC 3.5.1.129 N⁵-(cytidine 5′-diphosphoramidyl)-L-glutamine hydrolase
EC 3.5.1.130 [lysine-biosynthesis-protein LysW]-lysine/ornithine hydrolase
EC 3.5.1.131 1-carboxybiuret hydrolase
EC 3.5.1.132 [amino group carrier protein]-ornithine hydrolase
EC 3.5.1.133 N^α-acyl-L-glutamine aminoacylase
EC 3.5.1.134 (indol-3-yl)acetyl-L-aspartate hydrolase
EC 3.5.1.135 N⁴-acetylcytidine amidohydrolase
EC 3.5.1.136 N,N′-diacetylchitobiose non-reducing end deacetylase
EC 3.5.1.137 N-methylcarbamate hydrolase
EC 3.5.1.138 lipoamidase

EC 3.5.2 In Cyclic Amides

EC 3.5.2.1 barbiturase
EC 3.5.2.2 dihydropyrimidinase
EC 3.5.2.3 dihydroorotase
EC 3.5.2.4 carboxymethylhydantoinase
EC 3.5.2.5 allantoinase
EC 3.5.2.6 β-lactamase
EC 3.5.2.7 imidazolonepropionase
EC 3.5.2.8 deleted, included in EC 3.5.2.6
EC 3.5.2.9 5-oxoprolinase (ATP-hydrolysing)
EC 3.5.2.10 creatininase
EC 3.5.2.11 L-lysine-lactamase
EC 3.5.2.12 6-aminohexanoate-cyclic-dimer hydrolase
EC 3.5.2.13 2,5-dioxopiperazine hydrolase
EC 3.5.2.14 N-methylhydantoinase (ATP-hydrolysing)
EC 3.5.2.15 cyanuric acid amidohydrolase
EC 3.5.2.16 maleimide hydrolase
EC 3.5.2.17 hydroxyisourate hydrolase
EC 3.5.2.18 enamidase
EC 3.5.2.19 streptothricin hydrolase
EC 3.5.2.20 isatin hydrolase

EC 3.5.3 In Linear Amidines

EC 3.5.3.1 arginase
EC 3.5.3.2 guanidinoacetase
EC 3.5.3.3 creatinase
EC 3.5.3.4 allantoicase
EC 3.5.3.5 formiminoaspartate deiminase
EC 3.5.3.6 arginine deiminase
EC 3.5.3.7 guanidinobutyrase
EC 3.5.3.8 formimidoylglutamase
EC 3.5.3.9 allantoate deiminase
EC 3.5.3.10 D-arginase
EC 3.5.3.11 agmatinase
EC 3.5.3.12 agmatine deiminase
EC 3.5.3.13 formiminoglutamate deiminase
EC 3.5.3.14 amidinoaspartase
EC 3.5.3.15 protein-arginine deiminase
EC 3.5.3.16 methylguanidinase
EC 3.5.3.17 guanidinopropionase
EC 3.5.3.18 dimethylargininase
EC 3.5.3.19 transferred now EC 3.5.1.116
EC 3.5.3.20 diguanidinobutanase
EC 3.5.3.21 methylenediurea deaminase
EC 3.5.3.22 proclavaminate amidinohydrolase
EC 3.5.3.23 N-succinylarginine dihydrolase
EC 3.5.3.24 N¹-aminopropylagmatine ureohydrolase
EC 3.5.3.25 N^ω-hydroxy-L-arginine amidinohydrolase
EC 3.5.3.26 (S)-ureidoglycine aminohydrolase
EC 3.5.3.27 arginine dihydrolase

EC 3.5.4 In Cyclic Amidines

EC 3.5.4.1 cytosine deaminase
EC 3.5.4.2 adenine deaminase
EC 3.5.4.3 guanine deaminase
EC 3.5.4.4 adenosine deaminase
EC 3.5.4.5 cytidine deaminase
EC 3.5.4.6 AMP deaminase
EC 3.5.4.7 ADP deaminase
EC 3.5.4.8 aminoimidazolase
EC 3.5.4.9 methenyltetrahydrofolate cyclohydrolase
EC 3.5.4.10 IMP cyclohydrolase
EC 3.5.4.11 pterin deaminase
EC 3.5.4.12 dCMP deaminase
EC 3.5.4.13 dCTP deaminase
EC 3.5.4.14 transferred now included in EC 3.5.4.5
EC 3.5.4.15 guanosine deaminase
EC 3.5.4.16 GTP cyclohydrolase I
EC 3.5.4.17 adenosine-phosphate deaminase
EC 3.5.4.18 ATP deaminase
EC 3.5.4.19 phosphoribosyl-AMP cyclohydrolase
EC 3.5.4.20 pyrithiamine deaminase
EC 3.5.4.21 creatinine deaminase
EC 3.5.4.22 1-pyrroline-4-hydroxy-2-carboxylate deaminase
EC 3.5.4.23 blasticidin-S deaminase
EC 3.5.4.24 sepiapterin deaminase
EC 3.5.4.25 GTP cyclohydrolase II
EC 3.5.4.26 diaminohydroxyphosphoribosylaminopyrimidine deaminase
EC 3.5.4.27 methenyltetrahydromethanopterin cyclohydrolase
EC 3.5.4.28 S-adenosylhomocysteine deaminase
EC 3.5.4.29 GTP cyclohydrolase IIa
EC 3.5.4.30 dCTP deaminase (dUMP-forming)
EC 3.5.4.31 S-methyl-5'-thioadenosine deaminase
EC 3.5.4.32 8-oxoguanine deaminase
EC 3.5.4.33 tRNA(adenine³⁴) deaminase
EC 3.5.4.34 tRNA^Ala(adenine³⁷) deaminase
EC 3.5.4.35 tRNA(cytosine⁸) deaminase
EC 3.5.4.36 mRNA(cytosine⁶⁶⁶⁶) deaminase
EC 3.5.4.37 double-stranded RNA adenine deaminase
EC 3.5.4.38 single-stranded DNA cytosine deaminase
EC 3.5.4.39 GTP cyclohydrolase IV
EC 3.5.4.40 aminodeoxyfutalosine deaminase
EC 3.5.4.41 5'-deoxyadenosine deaminase
EC 3.5.4.42 N-isopropylammelide isopropylaminohydrolase
EC 3.5.4.43 hydroxydechloroatrazine ethylaminohydrolase
EC 3.5.4.44 ectoine hydrolase
EC 3.5.4.45 melamine deaminase
EC 3.5.4.46 cAMP deaminase

EC 3.5.5 In Nitriles

EC 3.5.5.1 nitrilase
EC 3.5.5.2 ricinine nitrilase
EC 3.5.5.3 now EC 4.3.99.1
EC 3.5.5.4 cyanoalanine nitrilase
EC 3.5.5.5 arylacetonitrilase
EC 3.5.5.6 bromoxynil nitrilase
EC 3.5.5.7 aliphatic nitrilase
EC 3.5.5.8 thiocyanate hydrolase

EC 3.5.99 In Other Compounds

EC 3.5.99.1 riboflavinase
EC 3.5.99.2 aminopyrimidine aminohydrolase
EC 3.5.99.3 hydroxydechloroatrazine ethylaminohydrolase
EC 3.5.99.3 transferred now EC 3.5.4.43
EC 3.5.99.4 transferred, now EC 3.5.4.42
EC 3.5.99.5 2-aminomuconate deaminase
EC 3.5.99.6 glucosamine-6-phosphate deaminase
EC 3.5.99.7 1-aminocyclopropane-1-carboxylate deaminase
EC 3.5.99.8 5-nitroanthranilic acid aminohydrolase
EC 3.5.99.9 2-nitroimidazole nitrohydrolase
EC 3.5.99.10 2-iminobutanoate/2-iminopropanoate deaminase
EC 3.5.99.11 2-aminomuconate deaminase (2-hydroxymuconate-forming)
EC 3.5.99.12 salsolinol synthase
EC 3.5.99.13 strictosidine synthase
EC 3.5.99.14 (S)-norcoclaurine synthase
EC 3.5.99.15 deacetylisoipecoside synthase
EC 3.5.99.16 deacetylipecoside synthase

EC 3.6 Acting on Acid Anhydrides

EC 3.6.1 In Phosphorus-Containing Anhydrides

EC 3.6.1.1 inorganic diphosphatase
EC 3.6.1.2 trimetaphosphatase
EC 3.6.1.3 deleted
EC 3.6.1.4 deleted, included in EC 3.6.1.3
EC 3.6.1.5 apyrase
EC 3.6.1.6 nucleoside diphosphate phosphatase
EC 3.6.1.7 acylphosphatase
EC 3.6.1.8 ATP diphosphatase
EC 3.6.1.9 nucleotide diphosphatase
EC 3.6.1.10 endopolyphosphatase
EC 3.6.1.11 exopolyphosphatase
EC 3.6.1.12 dCTP diphosphatase
EC 3.6.1.13 ADP-ribose diphosphatase
EC 3.6.1.14 adenosine-tetraphosphatase
EC 3.6.1.15 nucleoside-triphosphate phosphatase
EC 3.6.1.16 CDP-glycerol diphosphatase
EC 3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
EC 3.6.1.18 FAD diphosphatase
EC 3.6.1.19 transferred, now included in EC 3.6.1.9
EC 3.6.1.20 5'-acylphosphoadenosine hydrolase
EC 3.6.1.21 ADP-sugar diphosphatase
EC 3.6.1.22 NAD⁺ diphosphatase
EC 3.6.1.23 dUTP diphosphatase
EC 3.6.1.24 nucleoside phosphoacylhydrolase
EC 3.6.1.25 triphosphatase
EC 3.6.1.26 CDP-diacylglycerol diphosphatase
EC 3.6.1.27 undecaprenyl-diphosphate phosphatase
EC 3.6.1.28 thiamine-triphosphatase
EC 3.6.1.29 bis(5'-adenosyl)-triphosphatase
EC 3.6.1.30 deleted now covered by EC 3.6.1.59 and EC 3.6.1.62.
EC 3.6.1.31 phosphoribosyl-ATP diphosphatase
EC 3.6.1.32 now EC 3.6.4.1
EC 3.6.1.33 now EC 3.6.4.2
EC 3.6.1.34 now EC 3.6.3.14
EC 3.6.1.35 now EC 3.6.3.6
EC 3.6.1.36 now EC 3.6.3.10
EC 3.6.1.37 now EC 3.6.3.9
EC 3.6.1.38 now EC 3.6.3.8
EC 3.6.1.39 thymidine-triphosphatase
EC 3.6.1.40 guanosine-5'-triphosphate,3'-diphosphate phosphatase
EC 3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
EC 3.6.1.42 guanosine-diphosphatase
EC 3.6.1.43 dolichyldiphosphatase
EC 3.6.1.44 oligosaccharide-diphosphodolichol diphosphatase
EC 3.6.1.45 UDP-sugar diphosphatase
EC 3.6.1.46 now EC 3.6.5.1
EC 3.6.1.47 now EC 3.6.5.2
EC 3.6.1.48 now EC 3.6.5.3
EC 3.6.1.49 now EC 3.6.5.4
EC 3.6.1.50 now EC 3.6.5.5
EC 3.6.1.51 now EC 3.6.5.6
EC 3.6.1.52 diphosphoinositol-polyphosphate diphosphatase
EC 3.6.1.53 Mn²⁺-dependent ADP-ribose/CDP-alcohol diphosphatase
EC 3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase
EC 3.6.1.55 8-oxo-dGTP diphosphatase
EC 3.6.1.56 2-hydroxy-dATP diphosphatase
EC 3.6.1.57 UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose hydrolase
EC 3.6.1.58 8-oxo-dGDP phosphatase
EC 3.6.1.59 5'-(N⁷-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase
EC 3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming)
EC 3.6.1.61 diadenosine hexaphosphate hydrolase (ATP-forming)
EC 3.6.1.62 5'-(N⁷-methylguanosine 5'-triphospho)-[mRNA] hydrolase
EC 3.6.1.63 α-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase
EC 3.6.1.64 inosine diphosphate phosphatase
EC 3.6.1.65 (d)CTP diphosphatase
EC 3.6.1.66 XTP/dITP diphosphatase
EC 3.6.1.67 dihydroneopterin triphosphate diphosphatase
EC 3.6.1.68 geranyl diphosphate phosphohydrolase
EC 3.6.1.69 8-oxo-(d)GTP phosphatase
EC 3.6.1.70 guanosine-5'-diphospho-5'-[DNA] diphosphatase
EC 3.6.1.71 adenosine-5'-diphospho-5'-[DNA] diphosphatase
EC 3.6.1.72 DNA-3'-diphospho-5'-guanosine diphosphatase
EC 3.6.1.73 inosine/xanthosine triphosphatase
EC 3.6.1.74 mRNA 5′-phosphatase
EC 3.6.1.75 diacylglycerol diphosphate phosphatase
EC 3.6.1.76 prenyl-diphosphate phosphatase
EC 3.6.1.77 coenzyme A diphosphatase

EC 3.6.2 In Sulfonyl-Containing Anhydrides

EC 3.6.2.1 adenylylsulfatase
EC 3.6.2.2 phosphoadenylylsulfatase

EC 3.6.3 Acting on acid anhydrides; catalysing transmembrane movement of substances

EC 3.6.3.1 transferred, now EC 7.6.2.1
EC 3.6.3.2 transferred now EC 7.2.2.14
EC 3.6.3.3 transferred now EC 7.2.2.21
EC 3.6.3.4 transferred now EC 7.2.2.9
EC 3.6.3.5 transferred now EC 7.2.2.12
EC 3.6.3.6 transferred, now EC 7.1.2.1
EC 3.6.3.7 transferred, now EC 7.2.2.3
EC 3.6.3.8 transferred now EC 7.2.2.10
EC 3.6.3.9 transferred now EC 7.2.2.13
EC 3.6.3.10 transferred now EC 7.2.2.19
EC 3.6.3.11 deleted
EC 3.6.3.12 transferred now EC 7.2.2.6
EC 3.6.3.13 deleted identical to EC 3.6.3.1
EC 3.6.3.14 transferred, now EC 7.1.2.2
EC 3.6.3.15 transferred, now EC 7.2.2.1
EC 3.6.3.16 transferred now EC 7.3.2.7
EC 3.6.3.17 transferred now various members of sub-subclass EC 7.5.2
EC 3.6.3.18 transferred, now EC 7.5.2.2
EC 3.6.3.19 transferred, now EC 7.5.2.1
EC 3.6.3.20 transferred now EC 7.6.2.10
EC 3.6.3.21 transferred, now EC 7.4.2.1
EC 3.6.3.22 transferred, now EC 7.4.2.2
EC 3.6.3.23 transferred now EC 7.4.2.6
EC 3.6.3.24 transferred now EC 7.2.2.11
EC 3.6.3.25 transferred now EC 7.3.2.3
EC 3.6.3.26 transferred now EC 7.3.2.4
EC 3.6.3.27 transferred, now EC 7.3.2.1
EC 3.6.3.28 transferred, now EC 7.3.2.2
EC 3.6.3.29 transferred now EC 7.3.2.5
EC 3.6.3.30 transferred now EC 7.3.2.7
EC 3.6.3.31 transferred now EC 7.3.2.11
EC 3.6.3.32 transferred now EC 7.3.2.9
EC 3.6.3.33 transferred now EC 7.3.2.8
EC 3.6.3.34 transferred now EC 7.3.2.16, EC 7.3.2.17 and EC 7.3.2.18
EC 3.6.3.35 transferred now EC 7.3.2.5
EC 3.6.3.36 transferred now EC 7.6.2.7
EC 3.6.3.37 transferred now EC 7.6.2.6
EC 3.6.3.38 transferred now EC 7.6.2.12
EC 3.6.3.39 transferred now EC 7.5.2.5
EC 3.6.3.40 transferred now EC 7.5.2.4
EC 3.6.3.41 transferred now EC 7.6.2.5
EC 3.6.3.42 transferred now EC 7.5.2.3
EC 3.6.3.43 transferred now EC 7.4.2.5
EC 3.6.3.28 transferred, now EC 7.3.2.2
EC 3.6.3.44 transferred, now EC 7.6.2.2
EC 3.6.3.45 included with EC 7.6.2.2
EC 3.6.3.46 transferred, now EC 7.2.2.2
EC 3.6.3.47 transferred now EC 7.6.2.4
EC 3.6.3.48 transferred now EC 7.4.2.7
EC 3.6.3.49 transferred now EC 5.6.1.6
EC 3.6.3.50 transferred now EC 7.4.2.8
EC 3.6.3.51 transferred now EC 7.4.2.3
EC 3.6.3.52 transferred now EC 7.4.2.4
EC 3.6.3.53 transferred now EC 7.2.2.15
EC 3.6.3.54 transferred now EC 7.2.2.8
EC 3.6.3.55 transferred now EC 7.3.2.6

EC 3.6.4 Acting on acid anhydrides; involved in cellular and subcellular movement

EC 3.6.4.1 transferred now EC 5.6.1.6
EC 3.6.4.2 transferred now EC 5.6.1.2
EC 3.6.4.3 transferred, now EC 5.6.1.1
EC 3.6.4.4 transferred now EC 5.6.1.3
EC 3.6.4.5 transferred now EC 5.6.1.4
EC 3.6.4.6 vesicle-fusing ATPase
EC 3.6.4.7 peroxisome-assembly ATPase
EC 3.6.4.8 transferred now EC 5.6.1.5
EC 3.6.4.9 transferred now EC 5.6.1.7
EC 3.6.4.10 non-chaperonin molecular chaperone ATPase
EC 3.6.4.11 deleted
EC 3.6.4.12 transferred, now EC 5.6.2.3 and EC 5.6.2.4
EC 3.6.4.13 transferred now EC 5.6.2.5

EC 3.6.5 Acting on GTP; involved in cellular and subcellular movement

EC 3.6.5.1 heterotrimeric G-protein GTPase
EC 3.6.5.2 small monomeric GTPase
EC 3.6.5.3 protein-synthesizing GTPase
EC 3.6.5.4 signal-recognition-particle GTPase
EC 3.6.5.5 dynamin GTPase
EC 3.6.5.6 tubulin GTPase

EC 3.7 Acting on Carbon-Carbon Bonds

EC 3.7.1 In Ketonic Substances

EC 3.7.1.1 oxaloacetase
EC 3.7.1.2 fumarylacetoacetase
EC 3.7.1.3 kynureninase
EC 3.7.1.4 phloretin hydrolase
EC 3.7.1.5 acylpyruvate hydrolase
EC 3.7.1.6 acetylpyruvate hydrolase
EC 3.7.1.7 β-diketone hydrolase
EC 3.7.1.8 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
EC 3.7.1.9 2-hydroxymuconate-semialdehyde hydrolase
EC 3.7.1.10 cyclohexane-1,3-dione hydrolase
EC 3.7.1.11 cyclohexane-1,2-dione hydrolase
EC 3.7.1.12 cobalt-precorrin 5A hydrolase
EC 3.7.1.13 2-hydroxy-6-oxo-6-(2'-aminobiphenyl)hexa-2,4-dienoate hydrolase
EC 3.7.1.14 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase
EC 3.7.1.15 transferred now EC 4.2.1.138
EC 3.7.1.16 transferred now EC 3.3.2.12
EC 3.7.1.17 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
EC 3.7.1.18 6-oxocamphor hydrolase
EC 3.7.1.19 2,6-dihydroxypseudooxynicotine hydrolase
EC 3.7.1.20 3-fumarylpyruvate hydrolase
EC 3.7.1.21 6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase
EC 3.7.1.22 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)
EC 3.7.1.23 maleylpyruvate hydrolase
EC 3.7.1.24 2,4-diacetylphloroglucinol hydrolase
EC 3.7.1.25 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
EC 3.7.1.26 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase
EC 3.7.1.27 neryl diphosphate diphosphatase
EC 3.7.1.28 3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase

EC 3.8 Acting on Halide Bonds

EC 3.8.1 In C-Halide Compounds

EC 3.8.1.1 covered by EC 3.8.1.5
EC 3.8.1.2 (S)-2-haloacid dehalogenase
EC 3.8.1.3 haloacetate dehalogenase
EC 3.8.1.4 now EC 1.97.1.10
EC 3.8.1.5 haloalkane dehalogenase
EC 3.8.1.6 4-chlorobenzoate dehalogenase
EC 3.8.1.7 4-chlorobenzoyl-CoA dehalogenase
EC 3.8.1.8 atrazine chlorohydrolase EC 3.8.1.9 (R)-2-haloacid dehalogenase
EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)
EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)

EC 3.8.2 In P-Halide Compounds

EC 3.8.2.1 deleted

EC 3.8.2.2 diisopropyl-fluorophosphatase
EC 3.9 Acting on Phosphorus-Nitrogen Bonds

EC 3.9.1.1 phosphoamidase

EC 3.9.1.2 protein arginine phosphatase
EC 3.9.1.3 phosphohistidine phosphatase
EC 3.10 Acting on Sulfur-Nitrogen Bonds

EC 3.10.1.1 N-sulfoglucosamine sulfohydrolase
EC 3.10.1.2 cyclamate sulfohydrolase

EC 3.11 Acting on Carbon-Phosphorus Bonds

EC 3.11.1.1 phosphonoacetaldehyde hydrolase
EC 3.11.1.2 phosphonoacetate hydrolase
EC 3.11.1.3 phosphonopyruvate hydrolase

EC 3.12 Acting on Sulfur-Sulfur Bonds

EC 3.12.1.1 trithionate hydrolase

EC 3.13 Acting on Carbon-Sulfur Bonds

EC 3.13.1 Acting on Carbon-Sulfur Bonds

EC 3.13.1.1 UDP-sulfoquinovose synthase
EC 3.13.1.2 deleted probably EC 4.4.1.21
EC 3.13.1.3 2'-hydroxybiphenyl-2-sulfinate desulfinase
EC 3.13.1.4 3-sulfinopropanoyl-CoA desulfinase
EC 3.13.1.5 carbon disulfide hydrolase
EC 3.13.1.6 [CysO sulfur-carrier protein]-S-L-cysteine hydrolase
EC 3.13.1.7 carbonyl sulfide hydrolase
EC 3.13.1.8 now EC 3.13.2.3
EC 3.13.1.9 S-inosyl-L-homocysteine hydrolase

EC 3.13.2 Thioether and trialkylsulfonium hydrolases
EC 3.13.2.1 adenosylhomocysteinase
EC 3.13.2.2 transferred now EC 4.4.1.42
EC 3.13.2.3 (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming)
EC 3.13.2.4 lanthipeptide synthase