Formylation, Hydroxymethylation and Methylation using folate

Formylation

10-formyltetrahydrofolate (10-CHO-H4folate) to tetrahydrofolate (H4folate)

EC 2.1.2.2 phosphoribosylglycinamide formyltransferase (reaction)
EC 2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase (reaction)
EC 2.1.2.9 methionyl-tRNA formyltransferase (reaction)
EC 2.1.2.13 UDP-4-amino-4-deoxy-L-arabinose formyltransferase (reaction)

Hydroxymethylation

5,10-methylenetetrahydrofolate (5,10-CH2-H4folate) to tetrahydrofolate (H4folate)

EC 2.1.2.1 glycine hydroxymethyltransferase
EC 2.1.2.7 D-alanine 2-hydroxymethyltransferase
EC 2.1.2.8 deoxycytidylate 5-hydroxymethyltransferase
EC 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase (reaction)

Methylation

(a) 5,10-methylenetetrahydrofolate (5,10-CH2-H4folate) to tetrahydrofolate (H4folate)

EC 2.1.1.74 methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing)
EC 2.1.1.148 thymidylate synthase (FAD)

(b) 5,10-methylenetetrahydrofolate (5,10-CH2-H4folate) to dihydrofolate (H2folate)

EC 2.1.1.45 thymidylate synthase (reaction)
EC 2.1.1.54 deoxycytidylate C-methyltransferase

For folate symbols and abbreviations see folic acid nomenclature section 2.8

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