C1 Metabolism

Folate Involvement

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Only the part of the formula within the dotted lines is shown in the diagram below.

© IUBMB 2003

* see also EC 1.5.1.53 methylenetetrahydrofolate reductase (NADPH), EC 1.5.1.54 methylenetetrahydrofolate reductase (NADH), and EC 1.5.7.1 methylenetetrahydrofolate reductase (ferredoxin)

Notes:

1. For folate names and symbols click here

2. For the biosynthesis of dihydrofolate, click here.

3. The dissociation constant for the reaction
          5,10-CH2-H4folate = H4folate + CH2O
     is about 30 μM.

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histidine catabolism
purine biosynthesis
EC 1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)
EC 1.5.1.6 formyltetrahydrofolate dehydrogenase
EC 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
EC 1.5.1.53 methylenetetrahydrofolate reductase (NADPH)
EC 1.5.1.54 methylenetetrahydrofolate reductase (NADH)
EC 1.5.7.1 methylenetetrahydrofolate reductase (ferredoxin)
EC 2.1.1.13 5-methyltetrahydrofolate-homocysteine S-methyltransferase (mechanism)
EC 2.1.1.45 thymidylate synthase
EC 2.1.1.148 thymidylate synthase (FAD)
EC 2.1.2.5 glutamate formiminotransferase
EC 2.1.2.9 methionyl-tRNA formyltransferase
EC 3.5.4.9 methenyltetrahydrofolate cyclohydrolase
EC 4.3.1.4 formiminotetrahydrofolate cyclodeaminase
EC 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase
EC 6.3.4.3 formate-tetrahydrofolate ligase