Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature. Recommendations

Contents EC - EC

EC 5. Isomerases

EC 5.1 Racemases and Epimerases

EC 5.1.1 Acting on Amino Acids and Derivatives

EC alanine racemase
EC methionine racemase
EC glutamate racemase
EC proline racemase
EC lysine racemase
EC threonine racemase
EC diaminopimelate epimerase
EC 4-hydroxyproline epimerase
EC arginine racemase
EC amino-acid racemase
EC phenylalanine racemase (ATP-hydrolysing)
EC ornithine racemase
EC aspartate racemase
EC nocardicin-A epimerase
EC 2-aminohexano-6-lactam racemase
EC protein-serine epimerase
EC isopenicillin-N epimerase
EC serine racemase
EC O-ureido-serine racemase
EC L-Ala-D/L-Glu epimerase
EC isoleucine 2-epimerase
EC 4-hydroxyproline betaine 2-epimerase
EC UDP-N-acetyl-α-D-muramoyl-L-alanyl-L-glutamate epimerase
EC histidine racemase

EC 5.1.2 Acting on Hydroxy Acids and Derivatives

EC lactate racemase
EC mandelate racemase
EC 3-hydroxybutyryl-CoA epimerase
EC acetoin racemase
EC tartrate epimerase
EC isocitrate epimerase
EC tagaturonate epimerase

EC 5.1.3 Acting on Carbohydrates and Derivatives

EC ribulose-phosphate 3-epimerase
EC UDP-glucose 4-epimerase
EC aldose 1-epimerase
EC L-ribulose-5-phosphate 4-epimerase
EC UDP-arabinose 4-epimerase
EC UDP-glucuronate 4-epimerase
EC UDP-N-acetylglucosamine 4-epimerase
EC N-acylglucosamine 2-epimerase
EC N-acylglucosamine-6-phosphate 2-epimerase
EC CDP-paratose 2-epimerase
EC cellobiose epimerase
EC deleted
EC dTDP-4-dehydrorhamnose 3,5-epimerase
EC UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing)
EC glucose-6-phosphate 1-epimerase
EC UDP-glucosamine 4-epimerase
EC heparosan-N-sulfate-glucuronate 5-epimerase
EC GDP-mannose 3,5-epimerase
EC chondroitin-glucuronate 5-epimerase
EC ADP-glyceromanno-heptose 6-epimerase
EC maltose epimerase
EC L-ribulose-5-phosphate 3-epimerase
EC UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase
EC N-acetylneuraminate epimerase
EC dTDP-L-rhamnose 4-epimerase
EC N-acetyl-α-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase
EC dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
EC UDP-N-acetyl-L-fucosamine synthase
EC L-fucose mutarotase
EC D-psicose 3-epimerase
EC D-tagatose 3-epimerase
EC L-rhamnose mutarotase
EC 2-epi-5-epi-valiolone epimerase
EC monoglucosyldiacylglycerol epimerase
EC 2-epi-5-epi-valiolone 7-phosphate 2-epimerase
EC heparosan-glucuronate 5-epimerase
EC mannuronan 5-epimerase
EC D-erythrulose 1-phosphate 3-epimerase
EC deleted
EC D-tagatose 6-phosphate 4-epimerase
EC fructoselysine 3-epimerase
EC D-glucosamine-6-phosphate 4-epimerase
EC sulfoquinovose mutarotase
EC mannose 2-epimerase

EC 5.1.99 Acting on Other Compounds

EC methylmalonyl-CoA epimerase
EC 16-hydroxysteroid epimerase
EC allantoin racemase
EC α-methylacyl-CoA racemase
EC hydantoin racemase
EC NAD(P)H-hydrate epimerase
EC dihydroneopterin triphosphate 2'-epimerase
EC 7,8-dihydroneopterin epimerase

EC 5.2 cis-trans-Isomerases

EC maleate isomerase
EC maleylacetoacetate isomerase
EC deleted covered by EC, EC, EC, and EC
EC maleylpyruvate isomerase
EC linoleate isomerase
EC furylfuramide isomerase
EC transferred now EC
EC peptidylprolyl isomerase
EC farnesol 2-isomerase
EC 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
EC deleted entry
EC ζ-carotene isomerase
EC prolycopene isomerase
EC β-carotene isomerase

EC 5.3 Intramolecular Oxidoreductases

EC 5.3.1 Interconverting Aldoses and Ketoses

EC triose-phosphate isomerase
EC deleted
EC D-arabinose isomerase
EC L-arabinose isomerase
EC xylose isomerase
EC ribose-5-phosphate isomerase
EC mannose isomerase
EC mannose-6-phosphate isomerase
EC glucose-6-phosphate isomerase
EC now EC
EC deleted
EC glucuronate isomerase
EC arabinose-5-phosphate isomerase
EC L-rhamnose isomerase
EC D-lyxose ketol-isomerase
EC 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
EC 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
EC deleted
EC now EC
EC ribose isomerase
EC corticosteroid side-chain-isomerase
EC hydroxypyruvate isomerase
EC 5-methylthioribose-1-phosphate isomerase
EC phosphoribosylanthranilate isomerase
EC L-fucose isomerase
EC galactose-6-phosphate isomerase
EC 6-phospho-3-hexuloisomerase
EC D-sedoheptulose 7-phosphate isomerase
EC ribose 1,5-bisphosphate isomerase
EC 5-deoxy-glucuronate isomerase
EC sulfoquinovose isomerase
EC (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase
EC L-erythrulose 1-phosphate isomerase
EC D-erythrulose 4-phosphate isomerase
EC 2-dehydrotetronate isomerase
EC D-apiose isomerase
EC 4-deoxy-4-sulfo-D-erythrose isomerase

EC 5.3.2 Interconverting Keto- and Enol-Groups

EC phenylpyruvate tautomerase
EC oxaloacetate tautomerase
EC TDP-4-oxo-6-deoxy-α-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-α-D-galactopyranose-forming)
EC TDP-4-oxo-6-deoxy-α-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-α-D-glucopyranose-forming)
EC 2,3-diketo-5-methylthiopentyl-1-phosphate enolase
EC 2-hydroxymuconate tautomerase
EC ascopyrone tautomerase
EC 4-oxalomesaconate tautomerase

EC 5.3.3 Transposing C=C Bonds

EC steroid Δ-isomerase
EC isopentenyl-diphosphate Δ-isomerase
EC vinylacetyl-CoA Δ-isomerase
EC muconolactone Δ-isomerase
EC cholestenol Δ-isomerase
EC methylitaconate Δ-isomerase
EC aconitate Δ-isomerase
EC Δ32-enoyl-CoA isomerase
EC prostaglandin-A1 Δ-isomerase
EC 5-carboxymethyl-2-hydroxymuconate Δ-isomerase
EC isopiperitenone Δ-isomerase
EC L-dopachrome isomerase
EC polyenoic fatty acid isomerase
EC trans-2-decenoyl-[acyl-carrier protein] isomerase
EC transferred now EC
EC transferred now EC
EC trans-2,3-dihydro-3-hydroxyanthranilate isomerase
EC 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase
EC 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase
EC transferred now EC
EC Δ3,52,4-dienoyl-CoA isomerase
EC lutein isomerase
EC S-methyl-5-thioribulose 1-phosphate isomerase
EC neopinone isomerase

EC 5.3.4 Transposing S-S Bonds

EC protein disulfide-isomerase

EC 5.3.99 Other Intramolecular Oxidoreductases

EC deleted
EC prostaglandin-D synthase
EC prostaglandin-E synthase
EC prostaglandin-I synthase
EC thromboxane-A synthase
EC allene-oxide cyclase
EC styrene-oxide isomerase
EC capsanthin/capsorubin synthase
EC neoxanthin synthase
EC thiazole tautomerase
EC 2-keto-myo-inositol isomerase
EC lachrymatory-factor synthase

EC 5.4 Intramolecular Transferases

EC 5.4.1 Transferring Acyl Groups

EC lysolecithin acylmutase
EC transferred now EC
EC 2-methylfumaryl-CoA isomerase
EC D-galactarolactone isomerase

EC 5.4.2 Phosphotransferases (Phosphomutases)

EC transferred now EC and EC
EC phosphoglucomutase (α-D-glucose-1,6-bisphosphate-dependent)
EC phosphoacetylglucosamine mutase
EC bisphosphoglycerate mutase
EC phosphoglucomutase (glucose-cofactor)
EC β-phosphoglucomutase
EC phosphopentomutase
EC phosphomannomutase
EC phosphoenolpyruvate mutase
EC phosphoglucosamine mutase
EC phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
EC phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
EC phosphogalactosamine mutase

EC 5.4.3 Transferring Amino Groups

EC deleted
EC lysine 2,3-aminomutase
EC lysine 5,6-aminomutase
EC transferred, now included in EC
EC D-ornithine 4,5-aminomutase
EC tyrosine 2,3-aminomutase
EC leucine 2,3-aminomutase
EC glutamate-1-semialdehyde 2,1-aminomutase
EC glutamate 2,3-aminomutase
EC phenylalanine aminomutase (L-β-phenylalanine forming)
EC phenylalanine aminomutase (D-β-phenylalanine forming)

EC 5.4.4 Transferring hydroxy groups

EC (hydroxyamino)benzene mutase
EC isochorismate synthase
EC 3-(hydroxyamino)phenol mutase EC geraniol isomerase
EC 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase
EC 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase
EC hydroperoxy icosatetraenoate isomerase
EC linalool isomerase

EC 5.4.99 Transferring Other Groups

EC methylaspartate mutase
EC methylmalonyl-CoA mutase
EC 2-acetolactate mutase
EC 2-methyleneglutarate mutase
EC chorismate mutase
EC now EC
EC lanosterol synthase
EC cycloartenol synthase
EC UDP-galactopyranose mutase
EC deleted, included in EC
EC isomaltulose synthase
EC tRNA pseudouridine38-40 synthase
EC isobutyryl-CoA mutase
EC 4-carboxymethyl-4-methylbutenolide mutase
EC (1→4)-α-D-glucan 1-α-D-glucosylmutase
EC maltose α-D-glucosyltransferase
EC squalene—hopene cyclase
EC 5-(carboxyamino)imidazole ribonucleotide mutase
EC 16S rRNA pseudouridine516 synthase
EC 23S rRNA pseudouridine2457 synthase
EC 23S rRNA pseudouridine2604 synthase
EC 23S rRNA pseudouridine2605 synthase
EC 23S rRNA pseudouridine1911/1915/1917 synthase
EC 23S rRNA pseudouridine955/2504/2580 synthase
EC tRNA pseudouridine55 synthase
EC tRNA pseudouridine65 synthase
EC tRNA pseudouridine13 synthase
EC tRNA pseudouridine32 synthase
EC 23S rRNA pseudouridine746 synthase
EC UDP-arabinopyranose mutase
EC thalianol synthase
EC protostadienol synthase
EC cucurbitadienol synthase
EC germanicol synthase
EC taraxerol synthase
EC isomultiflorenol synthase
EC dammaradiene synthase
EC camelliol C synthase
EC β-amyrin synthase
EC α-amyrin synthase
EC lupeol synthase
EC tRNA pseudouridine31 synthase
EC 21S rRNA pseudouridine2819 synthase
EC mitochondrial tRNA pseudouridine27/28 synthase
EC tRNA pseudouridine38/39 synthase
EC shionone synthase
EC parkeol synthase
EC achilleol B synthase
EC glutinol synthase
EC friedelin synthase
EC baccharis oxide synthase
EC α-seco-amyrin synthase
EC marneral synthase
EC β-seco-amyrin synthase
EC δ-amyrin synthase
EC tirucalladienol synthase
EC baruol synthase
EC methylornithine synthase
EC dTDP-fucopyranose mutase
EC cobalt-precorrin-8 methylmutase
EC precorrin-8X methylmutase
EC D-ribose pyranase
EC ethylmalonyl-CoA mutase
EC 2-hydroxyisobutanoyl-CoA mutase
EC pre-α-onocerin synthase
EC α-onocerin synthase
EC 4-amino-4-deoxychorismate mutase

EC 5.5 Intramolecular Lyases

EC muconate cycloisomerase
EC 3-carboxy-cis,cis-muconate cycloisomerase
EC tetrahydroxypteridine cycloisomerase
EC inositol-3-phosphate synthase
EC carboxy-cis,cis-muconate cyclase
EC chalcone isomerase
EC chloromuconate cycloisomerase
EC (+)-bornyl diphosphate synthase
EC cycloeucalenol cycloisomerase
EC α-pinene-oxide decyclase
EC dichloromuconate cycloisomerase
EC copalyl diphosphate synthase
EC ent-copalyl diphosphate synthase
EC syn-copalyl diphosphate synthase
EC terpentedienyl-diphosphate synthase
EC halimadienyl-diphosphate synthase
EC (S)-β-macrocarpene synthase
EC lycopene ε-cyclase
EC lycopene β-cyclase
EC prosolanapyrone-III cycloisomerase
EC deleted
EC (–)-bornyl diphosphate synthase
EC aklanonic acid methyl ester cyclase
EC tocopherol cyclase
EC 3,6-anhydro-L-galactonate cycloisomerase
EC nogalonic acid methyl ester cyclase
EC D-galactarolactone cycloisomerase
EC (–)-kolavenyl diphosphate synthase
EC (+)-kolavenyl diphosphate synthase
EC labda-7,13-dienyl diphosphate synthase
EC hapalindole H synthase
EC 12-epi-hapalindole U synthase
EC 12-epi-fischerindole U synthase
EC (+)-cis,trans-nepetalactol synthase
EC (+)-cis,cis-nepetalactol synthase

EC 5.6 Isomerases altering macromolecular conformation

EC 5.6.1 Enzymes altering polypeptide conformation or assembly

EC microtubule-severing ATPase
EC dynein ATPase
EC plus-end-directed kinesin ATPase
EC minus-end-directed kinesin ATPase
EC proteasome ATPase
EC channel-conductance-controlling ATPase
EC chaperonin ATPase
EC myosin ATPase
EC (R)-2-hydroxyacyl-CoA dehydratase activating ATPase

EC 5.6.2 Enzymes altering nucleic acid conformation

EC DNA topoisomerase
EC DNA topoisomerase (ATP-hydrolysing)
EC DNA 5′-3′ helicase
EC DNA 3′-5′ helicase

EC 5.99 Other Isomerases

EC thiocyanate isomerase
EC transferred now EC
EC transferred now EC
EC 2-hydroxychromene-2-carboxylate isomerase

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