Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature. Recommendations

Contents EC - EC

EC 4 Lyases

EC 4.1 Carbon-Carbon Lyases

EC 4.1.1 Carboxy-Lyases

EC pyruvate decarboxylase
EC oxalate decarboxylase
EC now EC and EC
EC acetoacetate decarboxylase
EC acetolactate decarboxylase
EC aconitate decarboxylase
EC benzoylformate decarboxylase
EC oxalyl-CoA decarboxylase
EC malonyl-CoA decarboxylase
EC deleted, included in EC
EC aspartate 1-decarboxylase
EC aspartate 4-decarboxylase
EC deleted
EC valine decarboxylase
EC glutamate decarboxylase
EC hydroxyglutamate decarboxylase
EC ornithine decarboxylase
EC lysine decarboxylase
EC arginine decarboxylase
EC diaminopimelate decarboxylase
EC phosphoribosylaminoimidazole carboxylase
EC histidine decarboxylase
EC orotidine-5'-phosphate decarboxylase
EC aminobenzoate decarboxylase
EC tyrosine decarboxylase
EC deleted, included in EC
EC deleted, included in EC
EC aromatic-L-amino-acid decarboxylase
EC sulfoalanine decarboxylase
EC pantothenoylcysteine decarboxylase
EC phosphoenolpyruvate carboxylase
EC phosphoenolpyruvate carboxykinase (GTP)
EC diphosphomevalonate decarboxylase
EC dehydro-L-gulonate decarboxylase
EC UDP-glucuronate decarboxylase
EC phosphopantothenoylcysteine decarboxylase
EC uroporphyrinogen decarboxylase
EC phosphoenolpyruvate carboxykinase (diphosphate)
EC ribulose-bisphosphate carboxylase
EC hydroxypyruvate decarboxylase
EC now EC
EC carnitine decarboxylase
EC phenylpyruvate decarboxylase
EC 4-carboxymuconolactone decarboxylase
EC aminocarboxymuconate-semialdehyde decarboxylase
EC o-pyrocatechuate decarboxylase
EC tartronate-semialdehyde synthase
EC indole-3-glycerol-phosphate synthase
EC phosphoenolpyruvate carboxykinase (ATP)
EC adenosylmethionine decarboxylase
EC 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
EC 6-methylsalicylate decarboxylase
EC phenylalanine decarboxylase
EC dihydroxyfumarate decarboxylase
EC 4,5-dihydroxyphthalate decarboxylase
EC 3-oxolaurate decarboxylase
EC methionine decarboxylase
EC orsellinate decarboxylase
EC gallate decarboxylase
EC stipitatonate decarboxylase
EC 4-hydroxybenzoate decarboxylase
EC gentisate decarboxylase
EC protocatechuate decarboxylase
EC 2,2-dialkylglycine decarboxylase (pyruvate)
EC phosphatidylserine decarboxylase
EC uracil-5-carboxylate decarboxylase
EC UDP-galacturonate decarboxylase
EC 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
EC 3,4-dihydroxyphthalate decarboxylase
EC now EC
EC 2-oxoglutarate decarboxylase
EC branched-chain-2-oxoacid decarboxylase
EC tartrate decarboxylase
EC indolepyruvate decarboxylase
EC 5-guanidino-2-oxopentanoate decarboxylase
EC arylmalonate decarboxylase
EC 2-oxo-3-hexenedioate decarboxylase
EC acetylenedicarboxylate decarboxylase
EC sulfopyruvate decarboxylase
EC 4-hydroxyphenylpyruvate decarboxylase
EC threonine-phosphate decarboxylase
EC phosphonopyruvate decarboxylase
EC 4-hydroxyphenylacetate decarboxylase
EC D-dopachrome decarboxylase
EC 3-dehydro-L-gulonate-6-phosphate decarboxylase
EC diaminobutyrate decarboxylase
EC malonyl-[malonate decarboxylase] decarboxylase
EC biotin-independent malonate decarboxylase
EC now EC
EC peptidyl-glutamate 4-carboxylase
EC salicylate decarboxylase
EC indole-3-carboxylate decarboxylase
EC pyrrole-2-carboxylate decarboxylase
EC ethylmalonyl-CoA decarboxylase
EC L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
EC carboxynorspermidine decarboxylase
EC 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
EC 4-hydroxy-3-polyprenylbenzoate decarboxylase
EC phosphomevalonate decarboxylase
EC prephenate decarboxylase
EC malolactic enzyme
EC phenacrylate decarboxylase
EC γ-resorcylate decarboxylase
EC 3-dehydro-4-phosphotetronate decarboxylase
EC L-tryptophan decarboxylase
EC fatty acid photodecarboxylase
EC 3,4-dihydroxyphenylacetaldehyde synthase
EC 4-hydroxyphenylacetaldehyde synthase
EC phenylacetaldehyde synthase
EC bisphosphomevalonate decarboxylase
EC siroheme decarboxylase
EC oxaloacetate decarboxylase
EC trans-aconitate decarboxylase
EC cis-3-alkyl-4-alkyloxetan-2-one decarboxylase
EC indoleacetate decarboxylase
EC D-ornithine/D-lysine decarboxylase
EC 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
EC isophthalyl-CoA decarboxylase
EC phenylacetate decarboxylase
EC 3-oxoisoapionate decarboxylase
EC 3-oxoisoapionate-4-phosphate decarboxylase
EC L-cysteate decarboxylase
EC phenyl-phosphate phosphatase/carboxylase
EC malonyl-[acp] decarboxylase
EC 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase
EC anhydromevalonate phosphate decarboxylase
EC carboxyaminopropylagmatine decarboxylase

EC 4.1.2 Aldehyde-Lyases

EC deleted, included in EC
EC ketotetrose-phosphate aldolase
EC deleted
EC deoxyribose-phosphate aldolase
EC L-threonine aldolase
EC deleted
EC deleted, included in EC
EC indole-3-glycerol-phosphate lyase
EC phosphoketolase
EC (R)-mandelonitrile lyase
EC hydroxymandelonitrile lyase
EC ketopantoaldolase
EC fructose-bisphosphate aldolase
EC 2-dehydro-3-deoxy-phosphogluconate aldolase
EC now EC
EC now EC
EC L-fuculose-phosphate aldolase
EC 2-dehydro-3-deoxy-L-pentonate aldolase
EC rhamnulose-1-phosphate aldolase
EC 2-dehydro-3-deoxyglucarate aldolase
EC 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
EC fructose-6-phosphate phosphoketolase
EC 3-deoxy-D-manno-octulosonate aldolase
EC dimethylaniline-N-oxide aldolase
EC dihydroneopterin aldolase
EC phenylserine aldolase
EC sphinganine-1-phosphate aldolase
EC 2-dehydro-3-deoxy-D-pentonate aldolase
EC 5-dehydro-2-deoxyphosphogluconate aldolase
EC transferred now EC
EC deleted, included in EC
EC trimethylamine-oxide aldolase
EC fucosterol-epoxide lyase
EC 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
EC propioin synthase
EC lactate aldolase
EC deleted now covered by EC and EC
EC benzoin aldolase
EC deleted, same as EC
EC tagatose-bisphosphate aldolase
EC now EC
EC D-threonine aldolase
EC 3-hexulose-6-phosphate synthase
EC 2,3-epoxybenzoyl-CoA dihydrolase
EC trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
EC aliphatic (R)-hydroxynitrile lyase
EC (S)-hydroxynitrile lyase
EC low-specificity L-threonine aldolase
EC L-allo-threonine aldolase
EC 6-carboxytetrahydropterin synthase
EC 2-dehydro-3-deoxy-D-gluconate aldolase
EC 4-hydroxy-2-oxoheptanedioate aldolase
EC 2-keto-3-deoxy-L-rhamnonate aldolase
EC L-threo-3-deoxy-hexylosonate aldolase
EC 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
EC 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase
EC sulfofructosephosphate aldolase
EC 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase
EC dihydroneopterin phosphate aldolase
EC dihydroneopterin triphosphate aldolase
EC feruloyl-CoA hydratase/lyase
EC 5-deoxyribulose 1-phosphate aldolase
EC 2-hydroxyacyl-CoA lyase
EC 2-dehydro-3-deoxy-L-fuconate aldolase
EC ferulate hydratase/lyase
EC 4-coumarate hydratase/lyase

EC 4.1.3 Oxo-Acid-Lyases

EC isocitrate lyase
EC now EC
EC N-acetylneuraminate lyase
EC hydroxymethylglutaryl-CoA lyase
EC now EC
EC citrate (pro-3S)-lyase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC oxalomalate lyase
EC L-erythro-3-hydroxyaspartate aldolase
EC now EC
EC 4-hydroxy-2-oxoglutarate aldolase
EC 4-hydroxy-4-methyl-2-oxoglutarate aldolase
EC now EC
EC now EC
EC now EC
EC now EC
EC citramalate lyase
EC now EC
EC malyl-CoA lyase
EC (S)-citramalyl-CoA lyase
EC 3-hydroxy-3-isohexenylglutaryl-CoA lyase
EC anthranilate synthase
EC now EC
EC now EC
EC methylisocitrate lyase
EC now EC
EC 2,3-dimethylmalate lyase
EC now EC
EC citryl-CoA lyase
EC (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase
EC 1,4-dihydroxy-2-naphthoyl-CoA synthase
EC now EC
EC aminodeoxychorismate lyase
EC 4-hydroxy-2-oxovalerate aldolase
EC chorismate lyase
EC 3-hydroxy-D-aspartate aldolase
EC (4S)-4-hydroxy-2-oxoglutarate aldolase
EC 4-hydroxy-2-oxohexanoate aldolase
EC tRNA 4-demethylwyosine synthase (AdoMet-dependent)
EC 3-hydroxybenzoate synthase
EC (R)-citramalyl-CoA lyase

EC 4.1.99 Other Carbon-Carbon Lyases

EC tryptophanase
EC tyrosine phenol-lyase
EC deoxyribodipyrimidine photo-lyase
EC now EC
EC aldehyde oxygenase (deformylating)
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC benzylsuccinate synthase
EC 3,4-dihydroxy-2-butanone-4-phosphate synthase
EC (6-4)DNA photolyase
EC spore photoproduct lyase
EC deleted covered by EC
EC geosmin synthase
EC phosphomethylpyrimidine synthase
EC transferred now EC and EC
EC 2-iminoacetate synthase
EC 3-amino-4-hydroxybenzoate synthase
EC transferred now EC
EC GTP 3',8-cyclase
EC 5-hydroxybenzimidazole synthase
EC L-tyrosine isonitrile synthase
EC L-tryptophan isonitrile synthase
EC 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase
EC cyclopenase
EC 3'-dehydrocarminate deglycosidase
EC 5,8-dihydroxy-2-naphthoate synthase

EC 4.2 Carbon-Oxygen Lyases

EC 4.2.1 Hydro-Lyases

EC carbonic anhydrase
EC fumarate hydratase
EC aconitate hydratase
EC deleted now known to be a partial reaction catalysed by EC
EC arabinonate dehydratase
EC galactonate dehydratase
EC altronate dehydratase
EC mannonate dehydratase
EC dihydroxy-acid dehydratase
EC 3-dehydroquinate dehydratase
EC phosphopyruvate hydratase
EC phosphogluconate dehydratase
EC now EC
EC now EC
EC now EC
EC now EC
EC enoyl-CoA hydratase
EC methylglutaconyl-CoA hydratase
EC imidazoleglycerol-phosphate dehydratase
EC tryptophan synthase
EC now EC
EC cystathionine β-synthase
EC deleted
EC porphobilinogen synthase
EC L-arabinonate dehydratase
EC now EC
EC acetylenecarboxylate hydratase
EC propanediol dehydratase
EC now EC
EC glycerol dehydratase
EC maleate hydratase
EC L(+)-tartrate dehydratase
EC 3-isopropylmalate dehydratase
EC (S)-2-methylmalate dehydratase
EC (R)-2-methylmalate dehydratase
EC homoaconitate hydratase
EC now EC
EC now EC
EC gluconate dehydratase
EC glucarate dehydratase
EC 5-dehydro-4-deoxyglucarate dehydratase
EC galactarate dehydratase
EC 2-dehydro-3-deoxy-L-arabinonate dehydratase
EC myo-inosose-2 dehydratase
EC CDP-glucose 4,6-dehydratase
EC dTDP-glucose 4,6-dehydratase
EC GDP-mannose 4,6-dehydratase
EC D-glutamate cyclase
EC urocanate hydratase
EC pyrazolylalanine synthase
EC prephenate dehydratase
EC transferred, now EC
EC oleate hydratase
EC lactoyl-CoA dehydratase
EC 3-hydroxybutyryl-CoA dehydratase
EC itaconyl-CoA hydratase
EC isohexenylglutaconyl-CoA hydratase
EC deleted now covered by EC
EC 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
EC deleted now covered by EC
EC deleted now covered by EC
EC 5α-hydroxysteroid dehydratase
EC now EC
EC now EC
EC 3-cyanoalanine hydratase
EC cyanide hydratase
EC D-fuconate dehydratase
EC L-fuconate dehydratase
EC cyanamide hydratase
EC pseudouridylate synthase
EC identical to EC
EC now EC
EC protoaphin-aglucone dehydratase (cyclizing)
EC medium-chain-enoyl-CoA hydratase
EC uroporphyrinogen-III synthase
EC UDP-glucose 4,6-dehydratase
EC trans-L-3-hydroxyproline dehydratase
EC transferred now EC
EC 2-methylcitrate dehydratase
EC 2-oxopent-4-enoate hydratase
EC D(–)-tartrate dehydratase
EC xylonate dehydratase
EC 4-oxalmesaconate hydratase
EC nitrile hydratase
EC dimethylmaleate hydratase
EC deleted identical to EC
EC octopamine dehydratase
EC synephrine dehydratase
EC deleted, due to EC and EC
EC L-rhamnonate dehydratase
EC arogenate dehydratase
EC hydroperoxide dehydratase
EC ATP-dependent NAD(P)H-hydrate dehydratase
EC scytalone dehydratase
EC kievitone hydratase
EC 4a-hydroxytetrahydrobiopterin dehydratase
EC phaseollidin hydratase
EC 16α-hydroxyprogesterone dehydratase
EC 2-methylisocitrate dehydratase
EC cyclohexa-1,5-dienecarbonyl-CoA hydratase
EC trans-feruloyl-CoA hydratase
EC now EC
EC cyclohexyl-isocyanide hydratase
EC cyanase
EC 2-hydroxyisoflavanone dehydratase
EC bile-acid 7α-dehydratase
EC 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA dehydratase
EC ectoine synthase
EC methylthioribulose 1-phosphate dehydratase
EC aldos-2-ulose dehydratase
EC 1,5-anhydro-D-fructose dehydratase
EC acetylene hydratase
EC o-succinylbenzoate synthase
EC methanogen homoaconitase
EC UDP-N-acetylglucosamine 4,6-dehydratase (inverting)
EC 3-hydroxypropionyl-CoA dehydratase
EC 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
EC 3-dehydroshikimate dehydratase
EC enoyl-CoA hydratase 2
EC 4-hydroxybutanoyl-CoA dehydratase
EC colneleate synthase
EC tryptophan synthase (indole-salvaging)
EC tetrahymanol synthase
EC arabidiol synthase
EC dammarenediol II synthase
EC N-acetylmuramic acid 6-phosphate etherase
EC linalool dehydratase
EC lupan-3β,20-diol synthase
EC squalene—hopanol cyclase
EC D-lactate dehydratase
EC carotenoid 1,2-hydratase
EC 2-hydroxyhexa-2,4-dienoate hydratase
EC copal-8-ol diphosphate hydratase
EC very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
EC UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
EC ADP-dependent NAD(P)H-hydrate dehydratase
EC sporulenol synthase
EC (+)-caryolan-1-ol synthase
EC pterocarpan synthase
EC gluconate/galactonate dehydratase
EC 2-dehydro-3-deoxy-D-arabinonate dehydratase
EC 5'-oxoaverantin cyclase
EC versicolorin B synthase
EC 3-amino-5-hydroxybenzoate synthase
EC capreomycidine synthase
EC L-galactonate dehydratase
EC 5,6,7,8-tetrahydromethanopterin hydro-lyase
EC 2-methylfumaryl-CoA hydratase
EC crotonobetainyl-CoA hydratase
EC short-chain-enoyl-CoA hydratase
EC chorismate dehydratase
EC hydroperoxy icosatetraenoate dehydratase
EC 3-methylfumaryl-CoA hydratase
EC tetracenomycin F2 cyclase
EC methylthioacryloyl-CoA hydratase
EC L-talarate dehydratase
EC (R)-2-hydroxyisocaproyl-CoA dehydratase
EC galactarate dehydratase (D-threo-forming)
EC dTDP-4-dehydro-6-deoxy-α-D-glucopyranose 2,3-dehydratase
EC 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
EC bisanhydrobacterioruberin hydratase
EC 6-deoxy-6-sulfo-D-gluconate dehydratase
EC 2-oxo-hept-4-ene-1,7-dioate hydratase
EC dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase
EC chlorophyllide a 31-hydratase
EC phosphinomethylmalate isomerase
EC (R)-2-hydroxyglutaryl-CoA dehydratase
EC GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase
EC 3-vinyl bacteriochlorophyllide d 31-hydratase
EC 2-(ω-methylthio)alkylmalate dehydratase
EC cis-L-3-hydroxyproline dehydratase
EC trans-4-hydroxy-L-proline dehydratase
EC ent-8α-hydroxylabd-13-en-15-yl diphosphate synthase
EC peregrinol diphosphate synthase
EC (R)-3-(aryl)lactoyl-CoA dehydratase
EC L-lyxonate dehydratase
EC (2S)-3-sulfopropanediol dehydratase
EC difructose-dianhydride-III synthase
EC difructose-anhydride-I synthase
EC (E)-benzylidenesuccinyl-CoA hydratase
EC 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase
EC phosphomevalonate dehydratase
EC etheroleic acid synthase
EC (E)-benzylidenesuccinyl-CoA hydratase

EC 4.2.2 Acting on Polysaccharides

EC hyaluronate lyase
EC pectate lyase
EC mannuronate-specific alginate lyase
EC now EC and
EC chondroitin AC lyase
EC oligogalacturonide lyase
EC heparin lyase
EC heparin-sulfate lyase
EC pectate disaccharide-lyase
EC pectin lyase
EC guluronate-specific alginate lyase
EC xanthan lyase
EC exo-(1→4)-α-D-glucan lyase
EC glucuronan lyase
EC anhydrosialidase
EC levan fructotransferase (DFA-IV-forming)
EC inulin fructotransferase (DFA-I-forming)
EC inulin fructotransferase (DFA-III-forming)
EC chondroitin B lyase
EC chondroitin-sulfate-ABC endolyase
EC chondroitin-sulfate-ABC exolyase
EC pectate trisaccharide-lyase
EC rhamnogalacturonan endolyase
EC rhamnogalacturonan exolyase
EC gellan lyase
EC oligo-alginate lyase
EC pectin monosaccharide-lyase
EC α-L-rhamnosyl-(1→4)-β-D-glucuronate lyase
EC peptidoglycan lytic transglycosylase

EC 4.2.3 Acting on phosphates

EC threonine synthase
EC ethanolamine-phosphate phospho-lyase
EC methylglyoxal synthase
EC 3-dehydroquinate synthase
EC chorismate synthase
EC trichodiene synthase
EC pentalenene synthase
EC casbene synthase
EC aristolochene synthase
EC (–)-endo-fenchol synthase
EC sabinene-hydrate synthase
EC 6-pyruvoyltetrahydropterin synthase
EC (+)-δ-cadinene synthase
EC deleted now covered by EC and EC
EC myrcene synthase
EC (4S)-limonene synthase
EC taxadiene synthase
EC abieta-7,13-diene synthase
EC ent-kaurene synthase
EC (R)-limonene synthase
EC vetispiradiene synthase
EC germacradienol synthase
EC germacrene-A synthase
EC amorpha-4,11-diene synthase
EC S-linalool synthase
EC R-linalool synthase
EC isoprene synthase
EC ent-cassa-12,15-diene synthase
EC ent-sandaracopimaradiene synthase
EC ent-pimara-8(14),15-diene synthase
EC ent-pimara-9(11),15-diene synthase
EC levopimaradiene synthase
EC stemar-13-ene synthase
EC stemod-13(17)-ene synthase
EC syn-pimara-7,15-diene synthase
EC terpentetriene synthase
EC epi-isozizaene synthase
EC α-bisabolene synthase
EC epi-cedrol synthase
EC (Z)-γ-bisabolene synthase
EC elisabethatriene synthase
EC aphidicolan-16β-ol synthase
EC fusicocca-2,10(14)-diene synthase
EC isopimara-7,15-diene synthase
EC phyllocladan-16α-ol synthase
EC α-farnesene synthase
EC β-farnesene synthase
EC (3S,6E)-nerolidol synthase
EC (3R,6E)-nerolidol synthase
EC (+)-α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC β-phellandrene synthase (neryl-diphosphate-cyclizing)
EC (4S)-β-phellandrene synthase (geranyl-diphosphate-cyclizing)
EC (+)-endo-β-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC (–)-endo-α-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC (S)-β-bisabolene synthase
EC γ-humulene synthase
EC (–)-β-caryophyllene synthase
EC longifolene synthase
EC (E)-γ-bisabolene synthase
EC germacrene C synthase
EC 5-epiaristolochene synthase
EC (–)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]
EC (+)-cubenene synthase
EC (+)-epicubenol synthase
EC zingiberene synthase
EC β-selinene cyclase
EC cis-muuroladiene synthase
EC β-eudesmol synthase
EC (+)-α-barbatene synthase
EC patchoulol synthase
EC (E,E)-germacrene B synthase
EC α-gurjunene synthase
EC valencene synthase
EC presilphiperfolanol synthase
EC (–)-germacrene D synthase
EC (+)-δ-selinene synthase
EC (+)-germacrene D synthase
EC β-chamigrene synthase
EC thujopsene synthase
EC α-longipinene synthase
EC exo-α-bergamotene synthase
EC α-santalene synthase
EC β-santalene synthase
EC 10-epi-γ-eudesmol synthase
EC α-eudesmol synthase
EC 7-epi-α-selinene synthase
EC α-guaiene synthase
EC viridiflorene synthase
EC (+)-β-caryophyllene synthase
EC 5-epi-α-selinene synthase
EC cubebol synthase
EC (+)-γ-cadinene synthase
EC δ-guaiene synthase
EC γ-curcumene synthase
EC (–)-α-cuprenene synthase
EC avermitilol synthase
EC (–)-δ-cadinene synthase
EC (+)-T-muurolol synthase
EC labdatriene synthase
EC bicyclogermacrene synthase
EC 7-epi-sesquithujene synthase
EC sesquithujene synthase
EC ent-isokaurene synthase
EC α-humulene synthase
EC tricyclene synthase
EC (E)-β-ocimene synthase
EC (+)-car-3-ene synthase
EC 1,8-cineole synthase
EC (–)-sabinene synthase
EC (+)-sabinene synthase
EC (–)-α-terpineol synthase
EC (+)-α-terpineol synthase
EC terpinolene synthase
EC γ-terpinene synthase
EC α-terpinene synthase
EC (+)-camphene synthase
EC (–)-camphene synthase
EC 2-methylisoborneol synthase
EC (–)-α-pinene synthase
EC (–)-β-pinene synthase
EC (+)-α-pinene synthase
EC (+)-β-pinene synthase
EC β-sesquiphellandrene synthase
EC 2-deoxy-scyllo-inosose synthase
EC α-muurolene synthase
EC γ-muurolene synthase
EC β-copaene synthase
EC β-cubebene synthase
EC (+)-sativene synthase
EC tetraprenyl-β-curcumene synthase
EC miltiradiene synthase
EC neoabietadiene synthase
EC α-copaene synthase
EC 5-phosphooxy-L-lysine phospho-lyase
EC Δ6-protoilludene synthase
EC α-isocomene synthase
EC (E)-2-epi-β-caryophyllene synthase
EC (+)-epi-α-bisabolol synthase
EC valerena-4,7(11)-diene synthase
EC cis-abienol synthase
EC sclareol synthase
EC 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC kunzeaol synthase
EC geranyllinalool synthase
EC ophiobolin F synthase
EC cyclooctat-9-en-7-ol synthase
EC pimaradiene synthase
EC cembrene C synthase
EC nephthenol synthase
EC cembrene A synthase
EC pentamethylcyclopentadecatrienol synthase
EC 2-epi-5-epi-valiolone synthase
EC (5-formylfuran-3-yl)methyl phosphate synthase
EC demethyl-4-deoxygadusol synthase
EC 2-epi-valiolone synthase
EC hydroxysqualene synthase
EC (+)-isoafricanol synthase
EC (–)-spiroviolene synthase
EC tsukubadiene synthase
EC (2S,3R,6S,9S)-(–)-protoillud-7-ene synthase
EC (3S)-(+)-asterisca-2(9),6-diene synthase
EC (–)-α-amorphene synthase
EC (+)-corvol ether B synthase
EC (+)-eremophilene synthase
EC (1R,4R,5S)-(–)-guaia-6,10(14)-diene synthase
EC (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase
EC dolabella-3,7-dien-18-ol synthase
EC dolathalia-3,7,11-triene synthase
EC 7-epi-α-eudesmol synthase
EC 4-epi-cubebol synthase
EC (+)-corvol ether A synthase
EC 10-epi-juneol synthase
EC τ-cadinol synthase
EC (2E,6E)-hedycaryol synthase
EC 10-epi-cubebol synthase
EC sesterfisherol synthase
EC β-thujene synthase
EC stellata-2,6,19-triene synthase
EC guaia-4,6-diene synthase
EC pseudolaratriene synthase
EC selina-4(15),7(11)-diene synthase
EC pristinol synthase
EC nezukol synthase
EC 5-hydroxy-α-gurjunene synthase
EC ent-atiserene synthase
EC ent-13-epi-manoyl oxide synthase
EC (2Z,6E)-hedycaryol synthase
EC β-geranylfarnesene synthase
EC 9,13-epoxylabda-14-ene synthase
EC manoyl oxide synthase
EC cycloaraneosene synthase
EC labda-7,13(16),14-triene synthase
EC (12E)-labda-8(17),12,14-triene synthase
EC (–)-drimenol synthase
EC rhizathalene A synthase
EC dolabradiene synthase
EC eudesmane-5,11-diol synthase
EC α-selinene synthase
EC (–)-5-epieremophilene synthase
EC β-pinacene synthase
EC hydropyrene synthase
EC hydropyrenol synthase
EC isoelisabethatriene synthase
EC valerianol synthase
EC sodorifen synthase
EC (–)-cyatha-3,12-diene synthase
EC neoverrucosan-5β-ol synthase
EC verrucosan-2β-ol synthase
EC (R)-axinyssene synthase
EC lydicene synthase
EC (+)-exo-β-bergamotene synthase
EC (+)-δ-cadinol synthase
EC colleterpenol synthase
EC dolasta-1(15),8-diene synthase
EC δ-araneosene synthase
EC somaliensene A synthase
EC somaliensene B synthase
EC variediene synthase
EC (2E)-α-cericerene synthase
EC talaropentaene synthase
EC macrophomene synthase
EC phomopsene synthase
EC bonnadiene synthase
EC allokutznerene synthase
EC cattleyene synthase
EC (+)-2-epi-prezizaene synthase
EC (–)-α-cedrene synthase
EC (Z)-β-ocimene synthase
EC ent-beyerene synthase

EC 4.2.99 Other Carbon-Oxygen Lyases

EC now EC
EC now EC
EC now EC
EC now EC
EC deleted
EC deleted, included in EC and EC
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC carboxymethyloxysuccinate lyase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC DNA-(apurinic or apyrimidinic site) lyase
EC transferred entry now EC
EC 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
EC isochorismate lyase
EC tuliposide A-converting enzyme
EC tuliposide B-converting enzyme
EC thebaine synthase
EC unsaturated pyranuronate lyase

EC 4.3 Carbon-Nitrogen Lyases

EC 4.3.1 Ammonia-Lyases

EC aspartate ammonia-lyase
EC methylaspartate ammonia-lyase
EC histidine ammonia-lyase
EC formiminotetrahydrofolate cyclodeaminase
EC transferred, now divided into EC, EC and EC
EC β-alanyl-CoA ammonia-lyase
EC ethanolamine ammonia-lyase
EC now EC
EC glucosaminate ammonia-lyase
EC serine-sulfate ammonia-lyase
EC deleted
EC ornithine cyclodeaminase
EC carbamoyl-serine ammonia-lyase
EC 3-aminobutyryl-CoA ammonia-lyase
EC diaminopropionate ammonia-lyase
EC threo-3-hydroxy-L-aspartate ammonia-lyase
EC L-serine ammonia-lyase
EC D-serine ammonia-lyase
EC threonine ammonia-lyase
EC erythro-3-hydroxy-L-aspartate ammonia-lyase
EC identical to EC
EC 3,4-dihydroxyphenylalanine reductive deaminase
EC tyrosine ammonia-lyase
EC phenylalanine ammonia-lyase
EC phenylalanine/tyrosine ammonia-lyase
EC transferred now EC
EC threo-3-hydroxy-D-aspartate ammonia-lyase
EC L-lysine cyclodeaminase
EC D-glucosaminate-6-phosphate ammonia lyase
EC dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
EC L-tryptophan ammonia lyase
EC 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
EC (R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase

EC 4.3.2 Amidine-Lyases

EC argininosuccinate lyase
EC adenylosuccinate lyase
EC ureidoglycolate lyase
EC purine imidazole-ring cyclase
EC peptidylamidoglycolate lyase
EC γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase
EC glutathione-specific γ-glutamylcyclotransferase
EC γ-glutamylamine cyclotransferase
EC γ-glutamylcyclotransferase
EC imidazole glycerol-phosphate synthase
EC (3R)-3-[(carboxylmethyl)amino]fatty acid synthase

EC 4.3.3 Amine-Lyases

EC 3-ketovalidoxylamine C-N-lyase
EC transferred now EC
EC transferred now EC
EC transferred now EC
EC 4'-demethylrebeccamycin synthase
EC pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
EC 4-hydroxy-tetrahydrodipicolinate synthase
EC mimosinase

EC 4.3.99 Other Carbon-Nitrogen Lyases

EC now EC
EC now EC
EC 7-carboxy-7-deazaguanine synthase
EC choline trimethylamine-lyase
EC nitrosuccinate lyase

EC 4.4 Carbon-Sulfur Lyases

EC cystathionine γ-lyase
EC homocysteine desulfhydrase
EC dimethylpropiothetin dethiomethylase
EC alliin lyase
EC lactoylglutathione lyase
EC now included in EC
EC deleted, included in EC
EC now included in EC
EC L-3-cyanoalanine synthase
EC cysteine lyase
EC methionine γ-lyase
EC deleted
EC cysteine-S-conjugate β-lyase
EC 1-aminocyclopropane-1-carboxylate synthase
EC D-cysteine desulfhydrase
EC selenocysteine lyase
EC holocytochrome-c synthase
EC now EC
EC phosphosulfolactate synthase
EC leukotriene-C4 synthase
EC S-ribosylhomocysteine lyase
EC S-(hydroxymethyl)glutathione synthase
EC 2-hydroxypropyl-CoM lyase
EC (2R)-sulfolactate sulfo-lyase
EC L-cysteate sulfo-lyase
EC olivetolic acid cyclase
EC transferred, now EC
EC L-cysteine desulfidase
EC phycobiliprotein cysteine-84 phycobilin lyase
EC phycobiliprotein β-cysteine-155 phycobilin lyase
EC phycoerythrocyanin α-cysteine-84 phycoviolobilin lyase/isomerase
EC C-phycocyanin α-cysteine-84 phycocyanobilin lyase
EC R-phycocyanin α-cysteine-84 phycourobilin lyase/isomerase
EC isoprene-epoxide—glutathione S-transferase
EC L-cystine β-lyase
EC hercynylcysteine S-oxide lyase
EC pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase
EC isethionate sulfite-lyase
EC C-phycoerythrin α-cysteine-82 phycoerythrobilin lyase
EC C-phycoerythrin β-cysteine-48/59 phycoerythrobilin lyase
EC (2S)-3-sulfopropanediol sulfolyase
EC S-adenosyl-L-methionine lyase
EC canavanine-γ-lyase

EC 4.5 Carbon-Halide Lyases

EC DDT-dehydrochlorinase
EC 3-chloro-D-alanine dehydrochlorinase
EC dichloromethane dehalogenase
EC L-2-amino-4-chloropent-4-enoate dehydrochlorinase
EC S-carboxymethylcysteine synthase

EC 4.6 Phosphorus-Oxygen Lyases

EC adenylate cyclase
EC guanylate cyclase
EC now EC
EC now EC
EC now EC
EC cytidylate cyclase
EC now EC
EC now EC
EC now EC
EC now EC
EC now EC
EC 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
EC phosphatidylinositol diacylglycerol-lyase
EC glycosylphosphatidylinositol diacylglycerol-lyase
EC FAD-AMP lyase (cyclizing)
EC tRNA-intron lyase
EC cyclic pyranopterin monophosphate synthase
EC pancreatic ribonuclease
EC ribonuclease T2
EC ribonuclease U2
EC Enterobacter ribonuclease
EC Bacillus subtilis ribonuclease
EC ribotoxin
EC ribonuclease T1
EC bacteriophage T4 restriction endoribonuclease RegB
EC uridylate cyclase

EC 4.7 carbon-phosphorus lyases

EC α-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase

EC 4.8 Nitrogen-oxygen lyases

EC 4.8.1 Hydro-lyases

EC L-piperazate synthase
EC aliphatic aldoxime dehydratase
EC indoleacetaldoxime dehydratase
EC phenylacetaldoxime dehydratase
EC thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming)
EC N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming)
EC phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase
EC N-(sulfonatooxy)prop-2-enimidothioate sulfolyase

EC 4.98 ATP-independent chelatases

EC 4.98.1 Forming coordination complexes

EC protoporphyrin ferrochelatase

EC 4.99 Other Lyases

EC ransferred, now EC
EC alkylmercury lyase
EC sirohydrochlorin cobaltochelatase
EC sirohydrochlorin ferrochelatase
EC transferred. now EC
EC transferred. now EC
EC transferred. now EC
EC heme ligase
EC coproporphyrin ferrochelatase
EC magnesium dechelatase
EC sirohydrochlorin nickelchelatase
EC pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase

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