Nomenclature Committee of the
International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature

EC 1.4 to EC 1.97

Continued from contents EC 1.1 to EC 1.3

EC 1.4 Acting on the CH-NH₂ group of donors

EC 1.4.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.4.1.1 alanine dehydrogenase
EC 1.4.1.2 glutamate dehydrogenase
EC 1.4.1.3 glutamate dehydrogenase [NAD(P)⁺]
EC 1.4.1.4 glutamate dehydrogenase (NADP⁺)
EC 1.4.1.5 L-amino-acid dehydrogenase
EC 1.4.1.6 deleted, included in EC 1.4.4.1
EC 1.4.1.7 serine 2-dehydrogenase
EC 1.4.1.8 valine dehydrogenase (NADP⁺)
EC 1.4.1.9 leucine dehydrogenase
EC 1.4.1.10 glycine dehydrogenase
EC 1.4.1.11 L-erythro-3,5-diaminohexanoate dehydrogenase
EC 1.4.1.12 2,4-diaminopentanoate dehydrogenase
EC 1.4.1.13 glutamate synthase (NADPH)
EC 1.4.1.14 glutamate synthase (NADH)
EC 1.4.1.15 lysine dehydrogenase
EC 1.4.1.16 diaminopimelate dehydrogenase
EC 1.4.1.17 N-methylalanine dehydrogenase
EC 1.4.1.18 lysine 6-dehydrogenase
EC 1.4.1.19 tryptophan dehydrogenase
EC 1.4.1.20 phenylalanine dehydrogenase
EC 1.4.1.21 aspartate dehydrogenase
EC 1.4.1.22 deleted
EC 1.4.1.23 valine dehydrogenase (NAD⁺)
EC 1.4.1.24 3-dehydroquinate synthase II
EC 1.4.1.25 L-arginine dehydrogenase
EC 1.4.1.26 2,4-diaminopentanoate dehydrogenase (NAD⁺)
EC 1.4.1.27 glycine cleavage system
EC 1.4.1.28 secondary-alkyl amine dehydrogenase [NAD(P)⁺]

EC 1.4.2 With a cytochrome as acceptor

EC 1.4.2.1 glycine dehydrogenase (cytochrome)

EC 1.4.2.2 nicotine dehydrogenase
EC 1.4.2.3 pseudooxynicotine dehydrogenase
EC 1.4.3 With oxygen as acceptor

EC 1.4.3.1 D-aspartate oxidase
EC 1.4.3.2 L-amino-acid oxidase
EC 1.4.3.3 D-amino-acid oxidase
EC 1.4.3.4 amine oxidase
EC 1.4.3.5 pyridoxal 5'-phosphate synthase
EC 1.4.3.6 deleted now EC 1.4.3.21 and EC 1.4.3.22
EC 1.4.3.7 D-glutamate oxidase
EC 1.4.3.8 ethanolamine oxidase
EC 1.4.3.9 deleted, included in EC 1.4.3.4
EC 1.4.3.10 putrescine oxidase
EC 1.4.3.11 L-glutamate oxidase
EC 1.4.3.12 cyclohexylamine oxidase
EC 1.4.3.13 protein-lysine 6-oxidase
EC 1.4.3.14 L-lysine oxidase
EC 1.4.3.15 D-glutamate(D-aspartate) oxidase
EC 1.4.3.16 L-aspartate oxidase
EC 1.4.3.17 now EC 1.3.3.10
EC 1.4.3.18 deleted, not approved
EC 1.4.3.19 glycine oxidase
EC 1.4.3.20 L-lysine 6-oxidase
EC 1.4.3.21 primary-amine oxidase
EC 1.4.3.22 diamine oxidase
EC 1.4.3.23 7-chloro-L-tryptophan oxidase
EC 1.4.3.24 transferred now EC 1.4.2.3
EC 1.4.3.25 L-arginine oxidase
EC 1.4.3.26 pre-mycofactocin synthase
EC 1.4.3.27 homospermidine oxidase

EC 1.4.4 With a disulfide as acceptor

EC 1.4.4.1 now EC 1.21.4.1
EC 1.4.4.2 glycine dehydrogenase (aminomethyl-transferring)

EC 1.4.5 With a quinone or similar compound as acceptor

EC 1.4.5.1 D-amino acid dehydrogenase (quinone)

EC 1.4.7 With an iron-sulfur protein as acceptor

EC 1.4.7.1 glutamate synthase (ferredoxin)

EC 1.4.9 With a copper protein as acceptor

EC 1.4.9.1 methylamine dehydrogenase (amicyanin)
EC 1.4.9.2 aralkylamine dehydrogenase (azurin)

EC 1.4.98 With other, known, physiological acceptors

EC 1.4.98.1 now EC 1.4.9.1

EC 1.4.99 With unknown physiological acceptors

EC 1.4.99.1 now EC 1.4.99.6
EC 1.4.99.2 taurine dehydrogenase
EC 1.4.99.3 now EC 1.4.98.1
EC 1.4.99.4 now EC 1.4.9.2
EC 1.4.99.5 glycine dehydrogenase (cyanide-forming)
EC 1.4.99.6 D-arginine dehydrogenase

EC 1.5 Acting on the CH-NH group of donors

EC 1.5.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
EC 1.5.1.2 pyrroline-5-carboxylate reductase
EC 1.5.1.3 dihydrofolate reductase
EC 1.5.1.4 deleted, included in EC 1.5.1.3
EC 1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP⁺)
EC 1.5.1.6 formyltetrahydrofolate dehydrogenase
EC 1.5.1.7 saccharopine dehydrogenase (NAD⁺, L-lysine-forming)
EC 1.5.1.8 saccharopine dehydrogenase (NADP⁺, L-lysine-forming)
EC 1.5.1.9 saccharopine dehydrogenase (NAD⁺, L-glutamate-forming)
EC 1.5.1.10 saccharopine dehydrogenase (NADP⁺, L-glutamate-forming)
EC 1.5.1.11 D-octopine dehydrogenase
EC 1.5.1.12 now EC 1.2.1.88
EC 1.5.1.13 now EC 1.17.1.5
EC 1.5.1.14 deleted, included in EC 1.5.1.21
EC 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD⁺)
EC 1.5.1.16 D-lysopine dehydrogenase
EC 1.5.1.17 alanopine dehydrogenase
EC 1.5.1.18 ephedrine dehydrogenase
EC 1.5.1.19 D-nopaline dehydrogenase
EC 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]
EC 1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
EC 1.5.1.22 strombine dehydrogenase
EC 1.5.1.23 tauropine dehydrogenase
EC 1.5.1.24 N⁵-(carboxyethyl)ornithine synthase
EC 1.5.1.25 thiomorpholine-carboxylate dehydrogenase
EC 1.5.1.26 β-alanopine dehydrogenase
EC 1.5.1.27 1,2-dehydroreticulinium reductase (NADPH)
EC 1.5.1.28 opine dehydrogenase
EC 1.5.1.29 deleted, now covered by EC 1.5.1.38, EC 1.5.1.39 and EC 1.5.1.41
EC 1.5.1.30 flavin reductase (NADPH)
EC 1.5.1.31 berberine reductase
EC 1.5.1.32 vomilenine reductase
EC 1.5.1.33 pteridine reductase
EC 1.5.1.34 6,7-dihydropteridine reductase
EC 1.5.1.35 deleted, same as EC 1.2.1.19
EC 1.5.1.36 flavin reductase (NADH)
EC 1.5.1.37 FAD reductase (NADH)
EC 1.5.1.38 FMN reductase (NADPH)
EC 1.5.1.39 FMN reductase [NAD(P)H]
EC 1.5.1.40 8-hydroxy-5-deazaflavin:NADPH oxidoreductase
EC 1.5.1.41 riboflavin reductase [NAD(P)H]
EC 1.5.1.42 FMN reductase (NADH)
EC 1.5.1.43 carboxynorspermidine synthase
EC 1.5.1.44 festuclavine dehydrogenase
EC 1.5.1.45 FAD reductase [NAD(P)H]
EC 1.5.1.46 agroclavine dehydrogenase
EC 1.5.1.47 dihydromethanopterin reductase [NAD(P)⁺]
EC 1.5.1.48 2-methyl-1-pyrroline reductase
EC 1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]
EC 1.5.1.50 dihydromonapterin reductase
EC 1.5.1.51 N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase
EC 1.5.1.52 staphylopine dehydrogenase
EC 1.5.1.53 methylenetetrahydrofolate reductase (NADPH)
EC 1.5.1.54 methylenetetrahydrofolate reductase (NADH)
EC 1.5.1.55 carboxyaminopropylagmatine dehydrogenase
EC 1.5.1.56 3,17-didehydrostemmadenine reductase
EC 1.5.1.57 18-hydroxynorfluorocurarine reductase

EC 1.5.3 With oxygen as acceptor

EC 1.5.3.1 sarcosine oxidase (formaldehyde-forming)
EC 1.5.3.2 N-methyl-L-amino-acid oxidase
EC 1.5.3.3 deleted
EC 1.5.3.4 N⁶-methyl-lysine oxidase
EC 1.5.3.5 (S)-6-hydroxynicotine oxidase
EC 1.5.3.6 (R)-6-hydroxynicotine oxidase
EC 1.5.3.7 L-pipecolate oxidase
EC 1.5.3.8 deleted, included in EC 1.3.3.8
EC 1.5.3.9 now EC 1.21.3.3
EC 1.5.3.10 dimethylglycine oxidase
EC 1.5.3.11 deleted, now EC 1.5.3.13, EC 1.5.3.14, EC 1.5.3.15, EC 1.5.3.16 and EC 1.5.3.17
EC 1.5.3.12 dihydrobenzophenanthridine oxidase
EC 1.5.3.13 N¹-acetylpolyamine oxidase
EC 1.5.3.14 polyamine oxidase (propane-1,3-diamine-forming)
EC 1.5.3.15 N⁸-acetylspermidine oxidase (propane-1,3-diamine-forming)
EC 1.5.3.16 spermine oxidase
EC 1.5.3.17 non-specific polyamine oxidase
EC 1.5.3.18 L-saccharopine oxidase
EC 1.5.3.19 4-methylaminobutanoate oxidase (formaldehyde-forming)
EC 1.5.3.20 N-alkylglycine oxidase
EC 1.5.3.21 4-methylaminobutanoate oxidase (methylamine-forming)
EC 1.5.3.22 coenzyme F₄₂₀H₂ oxidase
EC 1.5.3.23 glyphosate oxidoreductase
EC 1.5.3.24 sarcosine oxidase (5,10-methylenetetrahydrofolate-forming)
EC 1.5.3.25 fructosyl amine oxidase (glucosone-forming)
EC 1.5.3.26 fructosyl amine oxidase (fructosamine-forming)
EC 1.5.3.27 2-(methylaminoethyl)phosphonate oxidase

EC 1.5.4 With a disulfide as acceptor

EC 1.5.4.1 pyrimidodiazepine synthase

EC 1.5.5 With a quinone or similar compound as acceptor

EC 1.5.5.1 electron-transferring-flavoprotein dehydrogenase
EC 1.5.5.2 proline dehydrogenase
EC 1.5.5.3 hydroxyproline dehydrogenase

EC 1.5.7 With an iron-sulfur protein as acceptor

EC 1.5.7.1 methylenetetrahydrofolate reductase (ferredoxin)
EC 1.5.7.2 coenzyme F₄₂₀ oxidoreductase (ferredoxin)
EC 1.5.7.3 N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin)

EC 1.5.8 With a flavin as acceptor

EC 1.5.8.1 dimethylamine dehydrogenase
EC 1.5.8.2 trimethylamine dehydrogenase
EC 1.5.8.3 sarcosine dehydrogenase
EC 1.5.8.4 dimethylglycine dehydrogenase

EC 1.5.98 With other, known, physiological acceptors

EC 1.5.98.1 methylenetetrahydromethanopterin dehydrogenase
EC 1.5.98.2 5,10-methylenetetrahydromethanopterin reductase
EC 1.5.98.3 coenzyme F₄₂₀:methanophenazine dehydrogenase

EC 1.5.99 With unknown physiological acceptors

EC 1.5.99.1 now EC 1.5.8.3
EC 1.5.99.2 now EC 1.5.8.4
EC 1.5.99.3 L-pipecolate dehydrogenase
EC 1.5.99.4 nicotine 6-hydroxylase
EC 1.5.99.5 methylglutamate dehydrogenase
EC 1.5.99.6 spermidine dehydrogenase
EC 1.5.99.7 now EC 1.5.8.2
EC 1.5.99.8 now EC 1.5.5.2
EC 1.5.99.9 now EC 1.5.98.1
EC 1.5.99.10 now EC 1.5.8.1
EC 1.5.99.11 now EC 1.5.98.2
EC 1.5.99.12 cytokinin dehydrogenase
EC 1.5.99.13 D-proline dehydrogenase
EC 1.5.99.14 6-hydroxypseudooxynicotine dehydrogenase
EC 1.5.99.15 dihydromethanopterin reductase (acceptor)
EC 1.5.99.16 2-(methylaminoethyl)phosphonate dehydrogenase (acceptor)

EC 1.6 Acting on NADH or NADPH

EC 1.6.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.6.1.1 NAD(P)⁺ transhydrogenase (Si-specific)
EC 1.6.1.2 transferred, now EC 7.1.1.1
EC 1.6.1.3 NAD(P)⁺ transhydrogenase
EC 1.6.1.4 NAD(P)⁺ transhydrogenase (ferredoxin)
EC 1.6.1.5 transferred, now EC 7.1.1.1

EC 1.6.2 With a heme protein as acceptor

EC 1.6.2.1 now EC 1.6.99.3
EC 1.6.2.2 cytochrome-b₅ reductase
EC 1.6.2.3 deleted
EC 1.6.2.4 NADPH—hemoprotein reductase
EC 1.6.2.5 NADPH—cytochrome-c₂ reductase
EC 1.6.2.6 leghemoglobin reductase

EC 1.6.3 With oxygen as acceptor

EC 1.6.3.1 NAD(P)H oxidase (H₂O₂-forming)
EC 1.6.3.2 NAD(P)H oxidase (H₂O-forming)
EC 1.6.3.3 NADH oxidase (H₂O₂-forming)
EC 1.6.3.4 NADH oxidase (H₂O-forming)
EC 1.6.3.5 renalase

EC 1.6.4 With a disulfide as acceptor

EC 1.6.4.1 now EC 1.8.1.6
EC 1.6.4.2 now EC 1.8.1.7
EC 1.6.4.3 now EC 1.8.1.4
EC 1.6.4.4 now EC 1.8.1.8
EC 1.6.4.5 now EC 1.8.1.9
EC 1.6.4.6 now EC 1.8.1.10
EC 1.6.4.7 now EC 1.8.1.11
EC 1.6.4.8 now EC 1.8.1.12
EC 1.6.4.9 now EC 1.8.1.13
EC 1.6.4.10 now EC 1.8.1.14

EC 1.6.5 With a quinone or similar compound as acceptor

EC 1.6.5.1 deleted
EC 1.6.5.2 NAD(P)H dehydrogenase (quinone)
EC 1.6.5.3 transferred, now EC 7.1.1.2
EC 1.6.5.4 monodehydroascorbate reductase (NADH)
EC 1.6.5.5 NADPH:quinone reductase
EC 1.6.5.6 p-benzoquinone reductase (NADPH)
EC 1.6.5.7 2-hydroxy-1,4-benzoquinone reductase
EC 1.6.5.8 transferred, now EC 7.2.1.1
EC 1.6.5.9 NADH:ubiquinone reductase (non-electrogenic)
EC 1.6.5.10 NADPH dehydrogenase (quinone)
EC 1.6.5.11 deleted, identical to EC 1.6.5.9
EC 1.6.5.12 demethylphylloquinone reductase

EC 1.6.6 With a nitrogenous group as acceptor

EC 1.6.6.1 now EC 1.7.1.1
EC 1.6.6.2 now EC 1.7.1.2
EC 1.6.6.3 now EC 1.7.1.3
EC 1.6.6.4 now EC 1.7.1.4
EC 1.6.6.5 now EC 1.7.99.3
EC 1.6.6.6 now EC 1.7.1.5
EC 1.6.6.7 now EC 1.7.1.6
EC 1.6.6.8 now EC 1.7.1.7
EC 1.6.6.9 deleted
EC 1.6.6.10 now EC 1.7.1.9
EC 1.6.6.11 now EC 1.7.1.10
EC 1.6.6.12 now EC 1.7.1.11
EC 1.6.6.13 now EC 1.7.1.12

EC 1.6.7 With a iron-sulfur protein as acceptor

EC 1.6.7.1 now EC 1.18.1.2
EC 1.6.7.2 now EC 1.18.1.1

EC 1.6.8 With a flavin as acceptor

EC 1.6.8.1 now EC 1.5.1.29
EC 1.6.8.2 now EC 1.5.1.30

EC 1.6.99 With unknown physiological acceptors

EC 1.6.99.1 NADPH dehydrogenase
EC 1.6.99.2 now EC 1.6.5.2
EC 1.6.99.3 covered by EC 7.1.1.2
EC 1.6.99.4 now EC 1.18.1.2
EC 1.6.99.5 now EC 1.6.5.11
EC 1.6.99.6 now EC 1.6.5.10
EC 1.6.99.7 now EC 1.5.1.34
EC 1.6.99.8 now EC 1.16.1.3
EC 1.6.99.9 now EC 1.16.1.4
EC 1.6.99.10 now included with EC 1.5.1.34
EC 1.6.99.11 now EC 1.16.1.5
EC 1.6.99.12 now EC 1.16.1.6
EC 1.6.99.13 now EC 1.16.1.7

EC 1.7 Acting on other nitrogenous compounds as donors

EC 1.7.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.7.1.1 nitrate reductase (NADH)
EC 1.7.1.2 nitrate reductase [NAD(P)H]
EC 1.7.1.3 nitrate reductase (NADPH)
EC 1.7.1.4 nitrite reductase [NAD(P)H]
EC 1.7.1.5 hyponitrite reductase
EC 1.7.1.6 azobenzene reductase
EC 1.7.1.7 GMP reductase
EC 1.7.1.8 deleted entry
EC 1.7.1.9 nitroquinoline-N-oxide reductase
EC 1.7.1.10 hydroxylamine reductase (NADH)
EC 1.7.1.11 4-(dimethylamino)phenylazoxybenzene reductase
EC 1.7.1.12 N-hydroxy-2-acetamidofluorene reductase
EC 1.7.1.13 preQ₁ reductase
EC 1.7.1.14 nitric oxide reductase [NAD(P), nitrous oxide-forming]
EC 1.7.1.15 nitrite reductase (NADH)
EC 1.7.1.16 nitrobenzene nitroreductase
EC 1.7.1.17 FMN-dependent NADH-azoreductase

EC 1.7.2 With a cytochrome as acceptor

EC 1.7.2.1 nitrite reductase (NO-forming)
EC 1.7.2.2 nitrite reductase (cytochrome; ammonia-forming)
EC 1.7.2.3 trimethylamine-N-oxide reductase (cytochrome c)
EC 1.7.2.4 nitrous-oxide reductase
EC 1.7.2.5 nitric oxide reductase (cytochrome c)
EC 1.7.2.6 hydroxylamine dehydrogenase
EC 1.7.2.7 hydrazine synthase
EC 1.7.2.8 hydrazine dehydrogenase
EC 1.7.2.9 hydroxylamine oxidase

EC 1.7.3 With oxygen as acceptor

EC 1.7.3.1 nitroalkane oxidase
EC 1.7.3.2 acetylindoxyl oxidase
EC 1.7.3.3 trimethylamine-N-oxide reductase
EC 1.7.3.4 deleted now covered by EC 1.7.2.6 and EC 1.7.3.6
EC 1.7.3.5 3-aci-nitropropanoate oxidase
EC 1.7.3.6 hydroxylamine oxidase (cytochrome)

EC 1.7.5 With a quinone or similar compound as acceptor

EC 1.7.5.1 nitrate reductase (quinone)

EC 1.7.5.2 nitric oxide reductase (menaquinol)
EC 1.7.6 With a nitrogenous group as acceptor

EC 1.7.6.1 nitrite dismutase

EC 1.7.7 With an iron-sulfur protein as acceptor

EC 1.7.7.1 ferredoxin—nitrite reductase
EC 1.7.7.2 ferredoxin—nitrate reductase

EC 1.7.99 With unknown physiological acceptors

EC 1.7.99.1 hydroxylamine reductase
EC 1.7.99.2 deleted
EC 1.7.99.3 included with EC 1.7.2.1
EC 1.7.99.4 now EC 1.7.1.1, EC 1.7.1.2, EC 1.7.1.3, EC 1.7.5.1, EC 1.7.7.2 and EC 1.9.6.1
EC 1.7.99.5 deleted, now included with EC 1.5.1.20
EC 1.7.99.6 now EC 1.7.2.4
EC 1.7.99.7 now EC 1.7.2.5
EC 1.7.99.8 now EC 1.7.2.8

EC 1.8 Acting on a sulfur group of donors

EC 1.8.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.8.1.1 deleted
EC 1.8.1.2 assimilatory sulfite reductase (NADPH)
EC 1.8.1.3 deleted
EC 1.8.1.4 dihydrolipoyl dehydrogenase
EC 1.8.1.5 2-oxopropyl-CoM reductase (carboxylating)
EC 1.8.1.6 cystine reductase
EC 1.8.1.7 glutathione-disulfide reductase
EC 1.8.1.8 protein-disulfide reductase
EC 1.8.1.9 thioredoxin-disulfide reductase
EC 1.8.1.10 CoA-glutathione reductase
EC 1.8.1.11 asparagusate reductase
EC 1.8.1.12 trypanothione-disulfide reductase
EC 1.8.1.13 bis-γ-glutamylcystine reductase
EC 1.8.1.14 CoA-disulfide reductase
EC 1.8.1.15 mycothione reductase
EC 1.8.1.16 glutathione amide reductase
EC 1.8.1.17 dimethylsulfone reductase
EC 1.8.1.18 NAD(P)H sulfur oxidoreductase (CoA-dependent)
EC 1.8.1.19 sulfide dehydrogenase
EC 1.8.1.20 4,4'-dithiodibutanoate disulfide reductase
EC 1.8.1.21 dissimilatory dimethyldisulfide reductase
EC 1.8.1.22 dissimilatory sulfite reductase system

EC 1.8.2 With a cytochrome as acceptor

EC 1.8.2.1 sulfite dehydrogenase (cytochrome)
EC 1.8.2.2 thiosulfate dehydrogenase
EC 1.8.2.3 sulfide-cytochrome-c reductase (flavocytochrome c)
EC 1.8.2.4 dimethyl sulfide:cytochrome c₂ reductase
EC 1.8.2.5 thiosulfate reductase (cytochrome)
EC 1.8.2.6 S-disulfanyl-L-cysteine oxidoreductase
EC 1.8.2.7 thiocyanate desulfurase

EC 1.8.3 With oxygen as acceptor

EC 1.8.3.1 sulfite oxidase
EC 1.8.3.2 thiol oxidase
EC 1.8.3.3 glutathione oxidase
EC 1.8.3.4 methanethiol oxidase
EC 1.8.3.5 prenylcysteine oxidase
EC 1.8.3.6 farnesylcysteine lyase
EC 1.8.3.7 formylglycine-generating enzyme

EC 1.8.4 With a disulfide as acceptor

EC 1.8.4.1 glutathione—homocystine transhydrogenase
EC 1.8.4.2 protein-disulfide reductase (glutathione)
EC 1.8.4.3 glutathione—CoA-glutathione transhydrogenase
EC 1.8.4.4 glutathione—cystine transhydrogenase
EC 1.8.4.5 now EC 1.8.4.13 and EC 1.8.4.14
EC 1.8.4.6 now EC 1.8.4.11
EC 1.8.4.7 enzyme-thiol transhydrogenase (glutathione-disulfide)
EC 1.8.4.8 phosphoadenylyl-sulfate reductase (thioredoxin)
EC 1.8.4.9 adenylyl-sulfate reductase (glutathione)
EC 1.8.4.10 adenylyl-sulfate reductase (thioredoxin)
EC 1.8.4.11 peptide-methionine (S)-S-oxide reductase
EC 1.8.4.12 peptide-methionine (R)-S-oxide reductase
EC 1.8.4.13 L-methionine (S)-S-oxide reductase
EC 1.8.4.14 L-methionine (R)-S-oxide reductase
EC 1.8.4.15 protein dithiol oxidoreductase (disulfide-forming)
EC 1.8.4.16 thioredoxin:protein disulfide reductase

EC 1.8.5 With a quinone or similar compound as acceptor

EC 1.8.5.1 glutathione dehydrogenase (ascorbate)
EC 1.8.5.2 thiosulfate dehydrogenase (quinone)
EC 1.8.5.3 respiratory dimethylsulfoxide reductase
EC 1.8.5.4 bacterial sulfide:quinone reductase
EC 1.8.5.5 thiosulfate reductase (quinone)
EC 1.8.5.6 sulfite dehydrogenase (quinone)
EC 1.8.5.7 glutathionyl-hydroquinone reductase
EC 1.8.5.8 eukaryotic sulfide quinone oxidoreductase
EC 1.8.5.9 protein dithiol:quinone oxidoreductase DsbB
EC 1.8.5.10 [DsrC]-trisulfide reductase

EC 1.8.6 With an nitrogenous group as acceptor

EC 1.8.6.1 deleted, included in EC 2.5.1.18

EC 1.8.7 With an iron-sulfur protein as acceptor

EC 1.8.7.1 assimilatory sulfite reductase (ferredoxin)
EC 1.8.7.2 ferredoxin:thioredoxin reductase

EC 1.8.98 With other, known, physiological acceptors

EC 1.8.98.1 dihydromethanophenazine:CoB-CoM heterodisulfide reductase
EC 1.8.98.2 sulfiredoxin
EC 1.8.98.3 sulfite reductase (coenzyme F₄₂₀)
EC 1.8.98.4 coenzyme F₄₂₀:CoB-CoM heterodisulfide,ferredoxin reductase
EC 1.8.98.5 H₂:CoB-CoM heterodisulfide,ferredoxin reductase
EC 1.8.98.6 formate:CoB-CoM heterodisulfide,ferredoxin reductase
EC 1.8.98.7 cysteine-type anaerobic sulfatase-maturating enzyme

EC 1.8.99 With unknown physiological acceptors

EC 1.8.99.1 deleted now covered by EC 1.8.1.2 and EC 1.8.7.1
EC 1.8.99.2 adenylyl-sulfate reductase
EC 1.8.99.3 deleted
EC 1.8.99.4 transferred now EC 1.8.4.8

EC 1.8.99.5 transferred now EC 1.8.1.22
EC 1.9 Acting on a heme group of donors

EC 1.9.3 With oxygen as acceptor

EC 1.9.3.1 now EC 7.1.1.9
EC 1.9.3.2 included with EC 1.7.2.1

EC 1.9.6 With a nitrogenous group as acceptor

EC 1.9.6.1 nitrate reductase (cytochrome)

EC 1.9.98 With other, known, physiological acceptors

EC 1.9.98.1 iron—cytochrome-c reductase

EC 1.9.99 With unknown physiological acceptors

EC 1.9.99.1 now EC 1.9.98.1
EC 1.10 Acting on diphenols and related substances as donors

EC 1.10.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.10.1.1 trans-acenaphthene-1,2-diol dehydrogenase

EC 1.10.2 With a cytochrome as acceptor

EC 1.10.2.1 deleted, now covered byEC 7.2.1.3
EC 1.10.2.2 transferred now EC 7.1.1.8

EC 1.10.3 With oxygen as acceptor

EC 1.10.3.1 catechol oxidase
EC 1.10.3.2 laccase
EC 1.10.3.3 L-ascorbate oxidase
EC 1.10.3.4 o-aminophenol oxidase
EC 1.10.3.5 3-hydroxyanthranilate oxidase
EC 1.10.3.6 rifamycin-B oxidase
EC 1.10.3.7 now EC 1.21.3.4
EC 1.10.3.8 now EC 1.21.3.5
EC 1.10.3.9 photosystem II
EC 1.10.3.10 transferred now EC 7.1.1.3
EC 1.10.3.11 ubiquinol oxidase (non-electrogenic)
EC 1.10.3.12 transferred now EC 7.1.1.5
EC 1.10.3.13 transferred now EC 7.1.1.4
EC 1.10.3.14 transferred now EC 7.1.1.7
EC 1.10.3.15 grixazone synthase
EC 1.10.3.16 dihydrophenazinedicarboxylate synthase
EC 1.10.3.17 superoxide oxidase

EC 1.10.5 With a quinone or related compound as acceptor
EC 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)

EC 1.10.9 With a copper protein as acceptor

EC 1.10.9.1 transferred now EC 7.1.1.6

EC 1.10.99 With unknown physiological acceptors

EC 1.10.99.1 now EC 1.10.9.1
EC 1.10.99.2 now EC 1.10.5.1
EC 1.10.99.3 now EC 1.23.5.1

EC 1.11 Acting on a peroxide as acceptor

EC 1.11.1 Peroxidases

EC 1.11.1.1 NADH peroxidase
EC 1.11.1.2 NADPH peroxidase
EC 1.11.1.3 fatty-acid peroxidase
EC 1.11.1.4 now EC 1.13.11.11
EC 1.11.1.5 cytochrome-c peroxidase
EC 1.11.1.6 catalase
EC 1.11.1.7 peroxidase
EC 1.11.1.8 iodide peroxidase
EC 1.11.1.9 glutathione peroxidase
EC 1.11.1.10 chloride peroxidase
EC 1.11.1.11 L-ascorbate peroxidase
EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase
EC 1.11.1.13 manganese peroxidase
EC 1.11.1.14 lignin peroxidase
EC 1.11.1.15 now described by EC 1.11.1.24, EC 1.11.1.25, EC 1.11.1.26, EC 1.11.1.27, EC 1.11.1.28, and EC 1.11.1.29
EC 1.11.1.16 versatile peroxidase
EC 1.11.1.17 glutathione amide-dependent peroxidase
EC 1.11.1.18 bromide peroxidase
EC 1.11.1.19 dye decolorizing peroxidase
EC 1.11.1.20 prostamide/prostaglandin F_2α synthase
EC 1.11.1.21 catalase-peroxidase
EC 1.11.1.22 hydroperoxy fatty acid reductase
EC 1.11.1.23 (S)-2-hydroxypropylphosphonic acid epoxidase
EC 1.11.1.24 thioredoxin-dependent peroxiredoxin
EC 1.11.1.25 glutaredoxin-dependent peroxiredoxin
EC 1.11.1.26 NADH-dependent peroxiredoxin
EC 1.11.1.27 glutathione-dependent peroxiredoxin
EC 1.11.1.28 lipoyl-dependent peroxiredoxin
EC 1.11.1.29 mycoredoxin-dependent peroxiredoxin

EC 1.11.2 With H₂O₂ as acceptor, one oxygen atom of which is incorporated into the product

EC 1.11.2.1 unspecific peroxygenase
EC 1.11.2.2 myeloperoxidase
EC 1.11.2.3 plant seed peroxygenase
EC 1.11.2.4 fatty-acid peroxygenase
EC 1.11.2.5 3-methyl-L-tyrosine peroxygenase
EC 1.11.2.6 L-tyrosine peroxygenase

EC 1.12 Acting on hydrogen as donor

EC 1.12.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.12.1.1 now EC 1.18.99.1
EC 1.12.1.2 hydrogen dehydrogenase
EC 1.12.1.3 hydrogen dehydrogenase (NADP⁺)
EC 1.12.1.4 hydrogenase (NAD⁺, ferredoxin)
EC 1.12.1.5 hydrogen dehydrogenase [NAD(P)⁺]

EC 1.12.2 With a cytochrome as acceptor

EC 1.12.2.1 cytochrome-c₃ hydrogenase

EC 1.12.5 With a quinone or similar compound as acceptor

EC 1.12.5.1 hydrogen:quinone oxidoreductase

EC 1.12.7 With an iron-sulfur protein as acceptor

EC 1.12.7.1 now EC 1.18.99.1
EC 1.12.7.2 ferredoxin hydrogenase

EC 1.12.98 With other, known, physiological acceptors

EC 1.12.98.1 coenzyme F₄₂₀ hydrogenase
EC 1.12.98.2 5,10-methenyltetrahydromethanopterin hydrogenase
EC 1.12.98.3 Methanosarcina-phenazine hydrogenase
EC 1.12.98.4 sulfhydrogenase

EC 1.12.99 With unknown physiological acceptors

EC 1.12.99.1 now EC 1.12.98.1
EC 1.12.99.2 deleted, composed of EC 1.12.98.3 and EC 1.8.98.1
EC 1.12.99.3 now EC 1.12.5.1
EC 1.12.99.4 now EC 1.12.98.2
EC 1.12.99.5 identical to EC 1.13.11.47
EC 1.12.99.6 hydrogenase (acceptor)

EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

EC 1.13.1.1 now EC 1.13.11.1
EC 1.13.1.2 now EC 1.13.11.2
EC 1.13.1.3 now EC 1.13.11.3
EC 1.13.1.4 now EC 1.13.11.4
EC 1.13.1.5 now EC 1.13.11.5
EC 1.13.1.6 now EC 1.13.11.6
EC 1.13.1.7 now EC 1.13.11.7
EC 1.13.1.8 now EC 1.13.11.8
EC 1.13.1.9 now EC 1.13.11.9
EC 1.13.1.10 now EC 1.13.11.10
EC 1.13.1.11 now EC 1.13.99.1
EC 1.13.1.12 now EC 1.13.11.11
EC 1.13.1.13 now EC 1.13.11.12

EC 1.13.11 With incorporation of two atoms of oxygen

EC 1.13.11.1 catechol 1,2-dioxygenase
EC 1.13.11.2 catechol 2,3-dioxygenase
EC 1.13.11.3 protocatechuate 3,4-dioxygenase
EC 1.13.11.4 gentisate 1,2-dioxygenase
EC 1.13.11.5 homogentisate 1,2-dioxygenase
EC 1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase
EC 1.13.11.7 deleted
EC 1.13.11.8 protocatechuate 4,5-dioxygenase
EC 1.13.11.9 2,5-dihydroxypyridine 5,6-dioxygenase
EC 1.13.11.10 7,8-dihydroxykynurenate 8,8a-dioxygenase
EC 1.13.11.11 tryptophan 2,3-dioxygenase
EC 1.13.11.12 linoleate 13S-lipoxygenase
EC 1.13.11.13 deleted
EC 1.13.11.14 2,3-dihydroxybenzoate 3,4-dioxygenase
EC 1.13.11.15 3,4-dihydroxyphenylacetate 2,3-dioxygenase
EC 1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
EC 1.13.11.17 indole 2,3-dioxygenase
EC 1.13.11.18 sulfur dioxygenase
EC 1.13.11.19 cysteamine dioxygenase
EC 1.13.11.20 cysteine dioxygenase
EC 1.13.11.21 now EC 1.14.99.36
EC 1.13.11.22 caffeate 3,4-dioxygenase
EC 1.13.11.23 2,3-dihydroxyindole 2,3-dioxygenase
EC 1.13.11.24 quercetin 2,3-dioxygenase
EC 1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
EC 1.13.11.26 peptide-tryptophan 2,3-dioxygenase
EC 1.13.11.27 4-hydroxyphenylpyruvate dioxygenase
EC 1.13.11.28 2,3-dihydroxybenzoate 2,3-dioxygenase
EC 1.13.11.29 stizolobate synthase
EC 1.13.11.30 stizolobinate synthase
EC 1.13.11.31 arachidonate 12-lipoxygenase
EC 1.13.11.32 now EC 1.13.12.16
EC 1.13.11.33 arachidonate 15-lipoxygenase
EC 1.13.11.34 arachidonate 5-lipoxygenase
EC 1.13.11.35 pyrogallol 1,2-oxygenase
EC 1.13.11.36 chloridazon-catechol dioxygenase
EC 1.13.11.37 hydroxyquinol 1,2-dioxygenase
EC 1.13.11.38 1-hydroxy-2-naphthoate 1,2-dioxygenase
EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
EC 1.13.11.40 arachidonate 8-lipoxygenase
EC 1.13.11.41 2,4'-dihydroxyacetophenone dioxygenase
EC 1.13.11.42 deleted
EC 1.13.11.43 lignostilbene αβ-dioxygenase
EC 1.13.11.44 deleted covered by EC 1.13.11.60 and EC 5.4.4.6
EC 1.13.11.45 linoleate 11-lipoxygenase
EC 1.13.11.46 4-hydroxymandelate synthase
EC 1.13.11.47 3-hydroxy-4-oxoquinoline 2,4-dioxygenase
EC 1.13.11.48 3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase
EC 1.13.11.49 chlorite O₂-lyase
EC 1.13.11.50 acetylacetone-cleaving enzyme
EC 1.13.11.51 9-cis-epoxycarotenoid dioxygenase
EC 1.13.11.52 indoleamine 2,3-dioxygenase
EC 1.13.11.53 acireductone dioxygenase (Ni²⁺-requiring)
EC 1.13.11.54 acireductone dioxygenase [iron(II)-requiring]
EC 1.13.11.55 sulfur oxygenase/reductase
EC 1.13.11.56 1,2-dihydroxynaphthalene dioxygenase
EC 1.13.11.57 gallate dioxygenase
EC 1.13.11.58 linoleate 9S-lipoxygenase
EC 1.13.11.59 torulene dioxygenase
EC 1.13.11.60 linoleate 8R-lipoxygenase
EC 1.13.11.61 linolenate 9R-lipoxygenase
EC 1.13.11.62 linoleate 10R-lipoxygenase
EC 1.13.11.63 β-carotene 15,15'-dioxygenase
EC 1.13.11.64 5-nitrosalicylate dioxygenase
EC 1.13.11.65 carotenoid isomerooxygenase
EC 1.13.11.66 hydroquinone 1,2-dioxygenase
EC 1.13.11.67 8'-apo-β-carotenoid 14',13'-cleaving dioxygenase
EC 1.13.11.68 9-cis-β-carotene 9',10'-cleaving dioxygenase
EC 1.13.11.69 carlactone synthase
EC 1.13.11.70 all-trans-10'-apo-β-carotenal 13,14-cleaving dioxygenase
EC 1.13.11.71 carotenoid-9',10'-cleaving dioxygenase
EC 1.13.11.72 2-hydroxyethylphosphonate dioxygenase
EC 1.13.11.73 methylphosphonate synthase
EC 1.13.11.74 2-aminophenol 1,6-dioxygenase
EC 1.13.11.75 all-trans-8'-apo-β-carotenal 15,15'-oxygenase
EC 1.13.11.76 2-amino-5-chlorophenol 1,6-dioxygenase
EC 1.13.11.77 oleate 10S-lipoxygenase
EC 1.13.11.78 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
EC 1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase
EC 1.13.11.80 (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
EC 1.13.11.81 7,8-dihydroneopterin oxygenase
EC 1.13.11.82 8'-apo-carotenoid 13,14-cleaving dioxygenase
EC 1.13.11.83 4-hydroxy-3-prenylphenylpyruvate oxygenase
EC 1.13.11.84 crocetin dialdehyde synthase
EC 1.13.11.85 exo-cleaving rubber dioxygenase
EC 1.13.11.86 5-aminosalicylate 1,2-dioxygenase
EC 1.13.11.87 endo-cleaving rubber dioxygenase
EC 1.13.11.88 isoeugenol monooxygenase
EC 1.13.11.89 hydroxymethylphosphonate dioxygenase
EC 1.13.11.90 [1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)
EC 1.13.11.91 3-mercaptopropionate dioxygenase
EC 1.13.11.92 fatty acid α-dioxygenase
EC 1.13.11.93 2-oxoadipate dioxygenase/decarboxylase
EC 1.13.11.94 4-vinylguaiacol dioxygenase
EC 1.13.11.95 2-oxoethane-1-sulfonamide synthase

EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

EC 1.13.12.1 arginine 2-monooxygenase
EC 1.13.12.2 lysine 2-monooxygenase
EC 1.13.12.3 tryptophan 2-monooxygenase
EC 1.13.12.4 lactate 2-monooxygenase
EC 1.13.12.5 Renilla-type luciferase
EC 1.13.12.6 Cypridina-luciferin 2-monooxygenase
EC 1.13.12.7 firefly luciferase
EC 1.13.12.8 Watasenia-luciferin 2-monooxygenase
EC 1.13.12.9 phenylalanine 2-monooxygenase
EC 1.13.12.10 covered by EC 1.14.13.59
EC 1.13.12.11 now EC 1.14.13.8
EC 1.13.12.12 now EC 1.13.11.67
EC 1.13.12.13 Oplophorus-luciferin 2-monooxygenase
EC 1.13.12.14 now EC 1.14.13.122
EC 1.13.12.15 3,4-dihydroxyphenylalanine oxidative deaminase
EC 1.13.12.16 nitronate monooxygenase
EC 1.13.12.17 dichloroarcyriaflavin A synthase
EC 1.13.12.18 dinoflagellate luciferase
EC 1.13.12.19 2-oxuglutarate dioxygenase (ethylene-forming)
EC 1.13.12.20 noranthrone monooxygenase
EC 1.13.12.21 tetracenomycin-F1 monooxygenase
EC 1.13.12.22 deoxynogalonate monooxygenase
EC 1.13.12.23 4-hydroxy-3-prenylbenzoate synthase
EC 1.13.12.24 calcium-regulated photoprotein

EC 1.13.99 Miscellaneous

EC 1.13.99.1 inositol oxygenase
EC 1.13.99.2 now EC 1.14.12.10
EC 1.13.99.3 tryptophan 2'-dioxygenase
EC 1.13.99.4 now EC 1.14.12.9
EC 1.13.99.5 now EC 1.13.11.47

EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

EC 1.14.1.1 now EC 1.14.14.1
EC 1.14.1.2 now EC 1.14.13.9
EC 1.14.1.3 deleted, covered by EC 1.14.99.7, EC 5.4.99.7
EC 1.14.1.4 now EC 1.14.99.2
EC 1.14.1.5 now EC 1.14.13.5
EC 1.14.1.6 now EC 1.14.15.4
EC 1.14.1.7 now EC 1.14.99.9
EC 1.14.1.8 now EC 1.14.99.10
EC 1.14.1.9 deleted
EC 1.14.1.10 now EC 1.14.99.11
EC 1.14.1.11 deleted

EC 1.14.2 With ascorbate as one donor

EC 1.14.2.1 now EC 1.14.17.1
EC 1.14.2.2 now EC 1.13.11.27

EC 1.14.3 With reduced pteridine as one donor

EC 1.14.3.1 now EC 1.14.16.1

EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

EC 1.14.11.1 γ-butyrobetaine dioxygenase
EC 1.14.11.2 procollagen-proline 4-dioxygenase
EC 1.14.11.3 pyrimidine-deoxynucleoside 2'-dioxygenase
EC 1.14.11.4 procollagen-lysine 5-dioxygenase
EC 1.14.11.5 deleted, included in EC 1.14.11.6
EC 1.14.11.6 thymine dioxygenase
EC 1.14.11.7 procollagen-proline 3-dioxygenase
EC 1.14.11.8 trimethyllysine dioxygenase
EC 1.14.11.9 flavanone 3-dioxygenase
EC 1.14.11.10 pyrimidine-deoxynucleoside 1'-dioxygenase
EC 1.14.11.11 hyoscyamine (6S)-dioxygenase
EC 1.14.11.12 gibberellin-44 dioxygenase
EC 1.14.11.13 gibberellin 2β-dioxygenase
EC 1.14.11.14 now EC 1.14.20.13
EC 1.14.11.15 gibberellin 3β-dioxygenase
EC 1.14.11.16 peptide-aspartate β-dioxygenase
EC 1.14.11.17 taurine dioxygenase
EC 1.14.11.18 phytanoyl-CoA dioxygenase
EC 1.14.11.19 now EC 1.14.20.4
EC 1.14.11.20 deacetoxyvindoline 4-hydroxylase
EC 1.14.11.21 clavaminate synthase
EC 1.14.11.22 now EC 1.14.20.5
EC 1.14.11.23 now EC 1.14.20.6
EC 1.14.11.24 2'-deoxymugineic-acid 2'-dioxygenase
EC 1.14.11.25 mugineic-acid 3-dioxygenase
EC 1.14.11.26 deacetoxycephalosporin-C hydroxylase
EC 1.14.11.27 [histone H3]-dimethyl-L-lysine³⁶ demethylase
EC 1.14.11.28 proline 3-hydroxylase
EC 1.14.11.29 hypoxia-inducible factor-proline dioxygenase
EC 1.14.11.30 hypoxia-inducible factor-asparagine dioxygenase
EC 1.14.11.31 thebaine 6-O-demethylase
EC 1.14.11.32 codeine 3-O-demethylase
EC 1.14.11.33 DNA oxidative demethylase
EC 1.14.11.34 now EC 1.14.20.7
EC 1.14.11.35 1-deoxypentalenic acid 11β-hydroxylase
EC 1.14.11.36 pentalenolactone F synthase
EC 1.14.11.37 kanamycin B dioxygenase
EC 1.14.11.38 verruculogen synthase
EC 1.14.11.39 L-asparagine hydroxylase
EC 1.14.11.40 enduracididine β-hydroxylase
EC 1.14.11.41 L-arginine hydroxylase
EC 1.14.11.42 tRNA^Phe (7-(3-amino-3-carboxypropyl)wyosine³⁷-C²)-hydroxylase
EC 1.14.11.43 (S)-dichlorprop dioxygenase (2-oxoglutarate)
EC 1.14.11.44 (R)-dichlorprop dioxygenase (2-oxoglutarate)
EC 1.14.11.45 L-isoleucine 4-hydroxylase
EC 1.14.11.46 2-aminoethylphosphonate dioxygenase
EC 1.14.11.47 50S ribosomal protein L16 3-hydroxylase
EC 1.14.11.48 xanthine dioxygenase
EC 1.14.11.49 uridine-5'-phosphate dioxygenase
EC 1.14.11.50 now EC 1.14.20.8
EC 1.14.11.51 DNA N⁶-methyladenine demethylase
EC 1.14.11.52 validamycin A dioxygenase
EC 1.14.11.53 mRNA N⁶-methyladenine demethylase
EC 1.14.11.54 mRNA N¹-methyladenine demethylase
EC 1.14.11.55 ectoine hydroxylase
EC 1.14.11.56 L-proline cis-4-hydroxylase
EC 1.14.11.57 L-proline trans-4-hydroxylase
EC 1.14.11.58 ornithine lipid ester-linked acyl 2-hydroxylase
EC 1.14.11.59 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
EC 1.14.11.60 scopoletin 8-hydroxylase
EC 1.14.11.61 feruloyl-CoA 6-hydroxylase
EC 1.14.11.62 trans-4-coumaroyl-CoA 2-hydroxylase
EC 1.14.11.63 peptidyl-lysine (3S)-dioxygenase
EC 1.14.11.64 glutarate dioxygenase
EC 1.14.11.65 [histone H3]-dimethyl-L-lysine⁹ demethylase
EC 1.14.11.66 [histone H3]-trimethyl-L-lysine⁹ demethylase
EC 1.14.11.67 [histone H3]-trimethyl-L-lysine⁴ demethylase
EC 1.14.11.68 [histone H3]-trimethyl-L-lysine²⁷ demethylase
EC 1.14.11.69 [histone H3]-trimethyl-L-lysine³⁶ demethylase
EC 1.14.11.70 7-deoxycylindrospermopsin hydroxylase
EC 1.14.11.71 methylphosphonate hydroxylase
EC 1.14.11.72 [2-(trimethylamino)ethyl]phosphonate dioxygenase
EC 1.14.11.73 [protein]-arginine 3-hydroxylase
EC 1.14.11.74 L-isoleucine 3¹-dioxygenase
EC 1.14.11.75 3¹-hydroxy-L-isoleucine 4-dioxygenase
EC 1.14.11.76 L-glutamate 3(R)-hydroxylase
EC 1.14.11.77 alkyl sulfatase
EC 1.14.11.78 (R)-3-[(carboxymethyl)amino]fatty acid dioxygenase/decarboxylase
EC 1.14.11.79 protein-L-histidine (3S)-3-hydroxylase
EC 1.14.11.80 methylcytosine dioxygenase
EC 1.14.11.81 (–)-cyclopenine synthase
EC 1.14.11.82 5-dehydro-6-demethoxyfumagillol dioxygenase

EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

EC 1.14.12.1 anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
EC 1.14.12.2 now EC 1.14.13.35
EC 1.14.12.3 benzene 1,2-dioxygenase
EC 1.14.12.4 now EC 1.14.13.242
EC 1.14.12.5 now EC 1.14.13.241
EC 1.14.12.6 now EC 1.14.13.66
EC 1.14.12.7 phthalate 4,5-dioxygenase
EC 1.14.12.8 4-sulfobenzoate 3,4-dioxygenase
EC 1.14.12.9 4-chlorophenylacetate 3,4-dioxygenase
EC 1.14.12.10 benzoate 1,2-dioxygenase
EC 1.14.12.11 toluene dioxygenase
EC 1.14.12.12 naphthalene 1,2-dioxygenase
EC 1.14.12.13 2-halobenzoate 1,2-dioxygenase
EC 1.14.12.14 2-aminobenzenesulfonate 2,3-dioxygenase
EC 1.14.12.15 terephthalate 1,2-dioxygenase
EC 1.14.12.16 2-hydroxyquinoline 5,6-dioxygenase
EC 1.14.12.17 nitric oxide dioxygenase
EC 1.14.12.18 biphenyl 2,3-dioxygenase
EC 1.14.12.19 3-phenylpropionate dioxygenase
EC 1.14.12.20 now EC 1.14.15.17
EC 1.14.12.21 now EC 1.14.13.208
EC 1.14.12.22 carbazole 1,9a-dioxygenase
EC 1.14.12.23 nitroarene dioxygenase
EC 1.14.12.24 2,4-dinitrotoluene dioxygenase
EC 1.14.12.25 p-cumate 2,3-dioxygenase
EC 1.14.12.26 chlorobenzene dioxygenase

EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen

EC 1.14.14.1 unspecific monooxygenase
EC 1.14.14.2 deleted, included in EC 1.14.14.1
EC 1.14.14.3 alkanal monooxygenase (FMN-linked)
EC 1.14.14.4 deleted, identical to EC 1.14.15.7
EC 1.14.14.5 alkanesulfonate monooxygenase
EC 1.14.14.6 now EC 1.14.13.111
EC 1.14.14.7 now EC 1.14.19.9
EC 1.14.14.8 anthranilate 3-monooxygenase (FAD)
EC 1.14.14.9 4-hydroxyphenylacetate 3-monooxygenase
EC 1.14.14.10 nitrilotriacetate monooxygenase
EC 1.14.14.11 styrene monooxygenase
EC 1.14.14.12 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione monooxygenase
EC 1.14.14.13 4-(L-γ-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase
EC 1.14.14.14 aromatase
EC 1.14.14.15 (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase
EC 1.14.14.16 steroid 21-monooxygenase
EC 1.14.14.17 squalene monooxygenase
EC 1.14.14.18 heme oxygenase (biliverdin-producing)
EC 1.14.14.19 steroid 17α-monooxygenase
EC 1.14.14.20 phenol 2-monooxygenase (FADH₂)
EC 1.14.14.21 dibenzothiophene monooxygenase
EC 1.14.14.22 dibenzothiophene sulfone monooxygenase
EC 1.14.14.23 cholesterol 7α-monooxygenase
EC 1.14.14.24 vitamin D 25-hydroxylase
EC 1.14.14.25 cholesterol 24-hydroxylase
EC 1.14.14.26 24-hydroxycholesterol 7α-hydroxylase
EC 1.14.14.27 resorcinol 4-hydroxylase (FADH₂)
EC 1.14.14.28 long-chain alkane monooxygenase
EC 1.14.14.29 25/26-hydroxycholesterol 7α-hydroxylase
EC 1.14.14.30 isobutylamine N-monooxygenase
EC 1.14.14.31 ipsdienol synthase
EC 1.14.14.32 17α-hydroxyprogesterone deacetylase
EC 1.14.14.33 ethylenediaminetetraacetate monooxygenase
EC 1.14.14.34 methanesulfonate monooxygenase (FMNH₂)
EC 1.14.14.35 dimethylsulfone monooxygenase
EC 1.14.14.36 tyrosine N-monooxygenase
EC 1.14.14.37 4-hydroxyphenylacetaldehyde oxime monooxygenase
EC 1.14.14.38 valine N-monooxygenase
EC 1.14.14.39 isoleucine N-monooxygenase
EC 1.14.14.40 phenylalanine N-monooxygenase
EC 1.14.14.41 (E)-2-methylbutanal oxime monooxygenase
EC 1.14.14.42 homomethionine N-monooxygenase
EC 1.14.14.43 (methylthio)alkanaldoxime N-monooxygenase
EC 1.14.14.44 phenylacetaldehyde oxime monooxygenase
EC 1.14.14.45 aromatic aldoxime N-monooxygenase
EC 1.14.14.46 pimeloyl-[acyl-carrier protein] synthase
EC 1.14.14.47 nitric-oxide synthase (flavodoxin)
EC 1.14.14.48 jasmonoyl-L-amino acid 12-hydroxylase
EC 1.14.14.49 12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase
EC 1.14.14.50 tabersonine 3-oxygenase
EC 1.14.14.51 (S)-limonene 6-monooxygenase
EC 1.14.14.52 (S)-limonene 7-monooxygenase
EC 1.14.14.53 (R)-limonene 6-monooxygenase
EC 1.14.14.54 phenylacetate 2-hydroxylase
EC 1.14.14.55 quinine 3-monooxygenase
EC 1.14.14.56 1,8-cineole 2-exo-monooxygenase
EC 1.14.14.57 taurochenodeoxycholate 6α-hydroxylase
EC 1.14.14.58 trimethyltridecatetraene synthase
EC 1.14.14.59 dimethylnonatriene synthase
EC 1.14.14.60 ferruginol monooxygenase
EC 1.14.14.61 carnosic acid synthase
EC 1.14.14.62 salviol synthase
EC 1.14.14.63 β-amyrin 16β-monooxygenase
EC 1.14.14.64 β-amyrin 6β-monooxygenase
EC 1.14.14.65 sugiol synthase
EC 1.14.14.66 marmesin synthase
EC 1.14.14.67 11-hydroxysugiol 20-monooxygenase
EC 1.14.14.68 syn-pimaradiene 3-monooxygenase
EC 1.14.14.69 ent-cassadiene hydroxylase
EC 1.14.14.70 ent-sandaracopimaradiene 3-hydroxylase
EC 1.14.14.71 cucurbitadienol 11-hydroxylase
EC 1.14.14.72 drimenol monooxygenase
EC 1.14.14.73 albendazole monooxygenase (sulfoxide-forming)
EC 1.14.14.74 albendazole monooxygenase (hydroxylating)
EC 1.14.14.75 fenbendazole monooxygenase (4'-hydroxylating)
EC 1.14.14.76 ent-isokaurene C2/C3-hydroxylase
EC 1.14.14.77 phenylacetonitrile α-monooxygenase
EC 1.14.14.78 phylloquinone ω-hydroxylase
EC 1.14.14.79 docosahexaenoic acid ω-hydroxylase
EC 1.14.14.80 long-chain fatty acid ω-monooxygenase
EC 1.14.14.81 flavanoid 3',5'-hydroxylase
EC 1.14.14.82 flavonoid 3'-monooxygenase
EC 1.14.14.83 geraniol 8-hydroxylase
EC 1.14.14.84 linalool 8-monooxygenase
EC 1.14.14.85 7-deoxyloganin 7-hydroxylase
EC 1.14.14.86 ent-kaurene monooxygenase
EC 1.14.14.87 2-hydroxyisoflavanone synthase
EC 1.14.14.88 isoflavone 3'-hydroxylase
EC 1.14.14.89 4'-methoxyisoflavone 2'-hydroxylase
EC 1.14.14.90 isoflavone 2'-hydroxylase
EC 1.14.14.91 trans-cinnamate 4-monooxygenase
EC 1.14.14.92 benzoate 4-monooxygenase
EC 1.14.14.93 3,9-dihydroxypterocarpan 6a-monooxygenase
EC 1.14.14.94 leukotriene-B₄ 20-monooxygenase
EC 1.14.14.95 germacrene A hydroxylase
EC 1.14.14.96 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase
EC 1.14.14.97 methyltetrahydroprotoberberine 14-monooxygenase
EC 1.14.14.98 protopine 6-monooxygenase
EC 1.14.14.99 (S)-limonene 3-monooxygenase
EC 1.14.14.100 dihydrosanguinarine 10-monooxygenase
EC 1.14.14.101 dihydrochelirubine 12-monooxygenase
EC 1.14.14.102 N-methylcoclaurine 3'-monooxygenase
EC 1.14.14.103 tabersonine 16-hydroxylase
EC 1.14.14.104 vinorine hydroxylase
EC 1.14.14.105 taxane 10β-hydroxylase
EC 1.14.14.106 taxane 13α-hydroxylase
EC 1.14.14.107 ent-kaurenoic acid monooxygenase
EC 1.14.14.108 2,5-diketocamphane 1,2-monooxygenase
EC 1.14.14.109 3-hydroxyindolin-2-one monooxygenase
EC 1.14.14.110 2-hydroxy-1,4-benzoxazin-3-one monooxygenase
EC 1.14.14.111 9β-pimara-7,15-diene oxidase
EC 1.14.14.112 ent-cassa-12,15-diene 11-hydroxylase
EC 1.14.14.113 α-humulene 10-hydroxylase
EC 1.14.14.114 amorpha-4,11-diene 12-monooxygenase
EC 1.14.14.115 11-oxo-β-amyrin 30-oxidase
EC 1.14.14.116 averantin hydroxylase
EC 1.14.14.117 aflatoxin B synthase
EC 1.14.14.118 tryprostatin B 6-hydroxylase
EC 1.14.14.119 fumitremorgin C monooxygenase
EC 1.14.14.120 dammarenediol 12-hydroxylase
EC 1.14.14.121 protopanaxadiol 6-hydroxylase
EC 1.14.14.122 oryzalexin E synthase
EC 1.14.14.123 oryzalexin D synthase
EC 1.14.14.124 dihydromonacolin L hydroxylase
EC 1.14.14.125 monacolin L hydroxylase
EC 1.14.14.126 β-amyrin 28-monooxygenase
EC 1.14.14.127 methyl farnesoate epoxidase
EC 1.14.14.128 farnesoate epoxidase
EC 1.14.14.129 long-chain acyl-CoA ω-monooxygenase
EC 1.14.14.130 laurate 7-monooxygenase
EC 1.14.14.131 bursehernin 5'-monooxygenase
EC 1.14.14.132 (–)-4'-demethyl-deoxypodophyllotoxin 4-hydroxylase
EC 1.14.14.133 1,8-cineole 2-endo-monooxygenase
EC 1.14.14.134 β-amyrin 24-hydroxylase
EC 1.14.14.135 glyceollin synthase
EC 1.14.14.136 deoxysarpagine hydroxylase
EC 1.14.14.137 (+)-abscisic acid 8'-hydroxylase
EC 1.14.14.138 lithocholate 6β-hydroxylase
EC 1.14.14.139 5β-cholestane-3α,7α-diol 12α-hydroxylase
EC 1.14.14.140 transferred now EC 1.14.14.162
EC 1.14.14.141 psoralen synthase
EC 1.14.14.142 8-dimethylallylnaringenin 2'-hydroxylase
EC 1.14.14.143 (+)-menthofuran synthase
EC 1.14.14.144 abieta-7,13-diene hydroxylase
EC 1.14.14.145 abieta-7,13-dien-18-ol hydroxylase
EC 1.14.14.146 geranylgeraniol 18-hydroxylase
EC 1.14.14.147 22α-hydroxysteroid 23-monooxygenase
EC 1.14.14.148 angelicin synthase
EC 1.14.14.149 5-epiaristolochene 1,3-dihydroxylase
EC 1.14.14.150 costunolide synthase
EC 1.14.14.151 premnaspirodiene oxygenase
EC 1.14.14.152 β-amyrin 11-oxidase
EC 1.14.14.153 indole-2-monooxygenase
EC 1.14.14.154 sterol 14α-demethylase
EC 1.14.14.155 3,6-diketocamphane 1,2-monooxygenase
EC 1.14.14.156 tryptophan N-monooxygenase
EC 1.14.14.157 indolin-2-one monooxygenase
EC 1.14.14.158 carotenoid ε hydroxylase
EC 1.14.14.159 dolabradiene monooxygenase
EC 1.14.14.160 zealexin A1 synthase
EC 1.14.14.161 nepetalactol monooxygenase
EC 1.14.14.162 flavanone 2-hydroxylase
EC 1.14.14.163 (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
EC 1.14.14.164 fraxetin 5-hydroxylase
EC 1.14.14.165 indole-3-carbonyl nitrile 4-hydroxylase
EC 1.14.14.166 (S)-N-methylcanadine 1-hydroxylase
EC 1.14.14.167 (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
EC 1.14.14.168 germacrene A acid 8β-hydroxylase
EC 1.14.14.169 eupatolide synthase
EC 1.14.14.170 8-epi-inunolide synthase
EC 1.14.14.171 β-amyrin 16α-hydroxylase
EC 1.14.14.172 3,5,6-trichloropyridin-2-ol monooxygenase
EC 1.14.14.173 2,4,6-trichlorophenol monooxygenase
EC 1.14.14.174 geranylhydroquinone 3''-hydroxylase
EC 1.14.14.175 ferruginol synthase
EC 1.14.14.176 taxadiene 5α-hydroxylase
EC 1.14.14.177 ultra-long-chain fatty acid ω-hydroxylase
EC 1.14.14.178 steroid 22S-hydroxylase
EC 1.14.14.179 brassinosteroid6-oxygenase
EC 1.14.14.180 brassinolide synthase
EC 1.14.14.181 sulfoquinovose monooxygenase
EC 1.14.14.182 taxoid 7β-hydroxylase
EC 1.14.14.183 taxoid 2α-hydroxylase
EC 1.14.14.184 5-dehydro-6-demethoxyfumagillol synthase
EC 1.14.14.185 taxane 9α-hydroxylase
EC 1.14.14.186 tryptamine 5-hydroxylase
EC 1.14.14.187 rhazimal synthase
EC 1.14.14.188 norfluorocurarine 18-hydroxylase
EC 1.14.14.189 strychnine 10-hydroxylase
EC 1.14.14.190 β-colubrine 11-hydroxylase

EC 1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

EC 1.14.15.1 camphor 5-monooxygenase
EC 1.14.15.2 now EC 1.14.13.162
EC 1.14.15.3 bacterial luciferase
EC 1.14.15.4 steroid 11β-monooxygenase
EC 1.14.15.5 corticosterone 18-monooxygenase
EC 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving)
EC 1.14.15.7 choline monooxygenase
EC 1.14.15.8 steroid 15β-monooxygenase
EC 1.14.15.9 spheroidene monooxygenase
EC 1.14.15.10 (+)-camphor 6-endo-hydroxylase
EC 1.14.15.11 pentalenic acid synthase
EC 1.14.15.12 now EC 1.14.14.46
EC 1.14.15.13 pulcherriminic acid synthase
EC 1.14.15.14 methyl-branched lipid ω-hydroxylase
EC 1.14.15.15 cholestanetriol 26-monooxygenase
EC 1.14.15.16 vitamin D₃ 24-hydroxylase
EC 1.14.15.17 pheophorbide-a oxygenase
EC 1.14.15.18 calcidiol 1-monooxygenase
EC 1.14.15.19 C-19 steroid 1α-hydroxylase
EC 1.14.15.20 heme oxygenase (biliverdin-producing, ferredoxin)
EC 1.14.15.21 zeaxanthin epoxidase
EC 1.14.15.22 vitamin D 1,25-hydroxylase
EC 1.14.15.23 chloroacetanilide N-alkylformylase
EC 1.14.15.24 β-carotene 3-hydroxylase
EC 1.14.15.25 p-cymene methyl-monooxygenase
EC 1.14.15.26 toluene methyl-monooxygenase
EC 1.14.15.27 β-dihydromenaquinone-9 ω-hydroxylase
EC 1.14.15.28 cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]
EC 1.14.15.29 cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
EC 1.14.15.30 3-ketosteroid 9α-monooxygenase
EC 1.14.15.31 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
EC 1.14.15.32 pentalenene oxygenase
EC 1.14.15.33 pikromycin synthase
EC 1.14.15.34 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
EC 1.14.15.35 6-deoxyerythronolide B hydroxylase
EC 1.14.15.36 sterol 14α-demethylase (ferredoxin)
EC 1.14.15.37 luteothin monooxygenase
EC 1.14.15.38 N,N-dimethyl phenylurea N-demethylase
EC 1.14.15.39 epi-isozizaene 5-monooxygenase
EC 1.14.15.40 cyclohexane-1-carboxylate 4-trans-hydroxylase
EC 1.14.15.41 L-tryptophan 4-nitrase
EC 1.14.15.42 L-tyrosine 3-nitrase
EC 1.14.15.43 nocardicin C N-oxygenase
EC 1.14.15.44 3-dehydro-2,22-dideoxyecdysone 22-hydroxylase
EC 1.14.15.45 4-hydroxy-3-polyprenylbenzoate 5-hydroxylase
EC 1.14.15.46 2-methoxy-6-polyprenylphenol 4-hydroxylase

EC 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen

EC 1.14.16.1 phenylalanine 4-monooxygenase
EC 1.14.16.2 tyrosine 3-monooxygenase
EC 1.14.16.3 deleted
EC 1.14.16.4 tryptophan 5-monooxygenase
EC 1.14.16.5 alkylglycerol monooxygenase
EC 1.14.16.6 mandelate 4-monooxygenaser
EC 1.14.16.7 phenylalanine 3-monooxygenase

EC 1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen

EC 1.14.17.1 dopamine β-monooxygenase
EC 1.14.17.2 deleted, included in EC 1.14.18.1
EC 1.14.17.3 peptidylglycine monooxygenase
EC 1.14.17.4 aminocyclopropanecarboxylate oxidase

EC 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen

EC 1.14.18.1 tyrosinase
EC 1.14.18.2 CMP-N-acetylneuraminate monooxygenase
EC 1.14.18.3 methane monooxygenase (particulate)
EC 1.14.18.4 phosphatidylcholine 12-monooxygenase
EC 1.14.18.5 sphingolipid C4-monooxygenase
EC 1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
EC 1.14.18.7 dihydroceramide fatty acyl 2-hydroxylase
EC 1.14.18.8 transferred now included with EC 1.14.14.139
EC 1.14.18.9 4α-methylsterol monooxygenase
EC 1.14.18.10 plant 4,4-dimethylsterol C-4α-methyl-monooxygenase
EC 1.14.18.11 plant 4α-monomethylsterol monooxygenase
EC 1.14.18.12 2-hydroxy fatty acid dioxygenase

EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

EC 1.14.19.1 stearoyl-CoA 9-desaturase
EC 1.14.19.2 stearoyl-[acyl-carrier-protein] 9-desaturase
EC 1.14.19.3 acyl-CoA 6-desaturase
EC 1.14.19.4 acyl-lipid (11-3)-desaturase
EC 1.14.19.5 acyl-CoA 11-(Z)-desaturase
EC 1.14.19.6 acyl-CoA (9+3)-desaturase
EC 1.14.19.7 now EC 1.11.1.23
EC 1.14.19.8 pentalenolactone synthase
EC 1.14.19.9 tryptophan 7-halogenase
EC 1.14.19.10 icosanoyl-CoA 5-desaturase
EC 1.14.19.11 palmitoyl-[acyl-carrier-protein] 4-desaturase
EC 1.14.19.12 acyl-lipid ω-(9-4) desaturase
EC 1.14.19.13 acyl-CoA 15-desaturase
EC 1.14.19.14 linoleoyl-lipid Δ⁹ conjugase
EC 1.14.19.15 (11Z)-hexadec-11-enoyl-CoA conjugase
EC 1.14.19.16 linoleoyl-lipid Δ¹² conjugase (11E,13Z-forming)
EC 1.14.19.17 sphingolipid 4-desaturase
EC 1.14.19.18 sphingolipid 8-(E)-desaturase
EC 1.14.19.19 sphingolipid 10-desaturase
EC 1.14.19.20 Δ⁷-sterol 5(6)-desaturase
EC 1.14.19.21 cholesterol 7-desaturase
EC 1.14.19.22 acyl-lipid ω-6 desaturase (cytochrome b₅)
EC 1.14.19.23 acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)
EC 1.14.19.24 acyl-CoA 11-(E)-desaturase
EC 1.14.19.25 acyl-lipid ω-3 desaturase (cytochrome b₅)
EC 1.14.19.26 acyl-[acyl-carrier-protein] 6-desaturase
EC 1.14.19.27 sn-2 palmitoyl-lipid 9-desaturase
EC 1.14.19.28 sn-1 stearoyl-lipid 9-desaturase
EC 1.14.19.29 sphingolipid 8-(E/Z)-desaturase
EC 1.14.19.30 acyl-lipid (8-3)-desaturase
EC 1.14.19.31 acyl-lipid (7-3)-desaturase
EC 1.14.19.32 palmitoyl-CoA 14-(E/Z)-desaturase
EC 1.14.19.33 Δ¹² acyl-lipid conjugase (11E,13E-forming)
EC 1.14.19.34 acyl-lipid (9+3)-(E)-desaturase
EC 1.14.19.35 sn-2 acyl-lipid ω-3 desaturase (ferredoxin)
EC 1.14.19.36 sn-1 acyl-lipid ω-3 desaturase (ferredoxin)
EC 1.14.19.37 acyl-CoA 5-desaturase
EC 1.14.19.38 acyl-lipid Δ⁶-acetylenase
EC 1.14.19.39 acyl-lipid Δ¹²-acetylenase
EC 1.14.19.40 hex-5-enoyl-[acyl-carrier protein] acetylenase
EC 1.14.19.41 sterol 22-desaturase
EC 1.14.19.42 palmitoyl-[glycerolipid] 7-desaturase
EC 1.14.19.43 palmitoyl-[glycerolipid] 3-(E)-desaturase
EC 1.14.19.44 acyl-CoA (8-3)-desaturase
EC 1.14.19.45 sn-1 oleoyl-lipid 12-desaturase
EC 1.14.19.46 sn-1 linoleoyl-lipid 6-desaturase
EC 1.14.19.47 acyl-lipid (9-3)-desaturase
EC 1.14.19.48 tert-amyl alcohol desaturase
EC 1.14.19.49 tetracycline 7-halogenase
EC 1.14.19.50 noroxomaritidine synthase
EC 1.14.19.51 (S)-corytuberine synthase
EC 1.14.19.52 camalexin synthase
EC 1.14.19.53 all-trans-retinol 3,4-desaturase
EC 1.14.19.54 1,2-dehydroreticuline synthase
EC 1.14.19.55 4-hydroxybenzoate brominase (decarboxylating)
EC 1.14.19.56 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase
EC 1.14.19.57 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase
EC 1.14.19.58 tryptophan 5-halogenase
EC 1.14.19.59 tryptophan 6-halogenase
EC 1.14.19.60 7-chloro-L-tryptophan 6-halogenase
EC 1.14.19.61 dihydrorhizobitoxine desaturase
EC 1.14.19.62 secologanin synthase
EC 1.14.19.63 pseudobaptigenin synthase
EC 1.14.19.64 (S)-stylopine synthase
EC 1.14.19.65 (S)-cheilanthifoline synthase
EC 1.14.19.66 berbamunine synthase
EC 1.14.19.67 salutaridine synthase
EC 1.14.19.68 (S)-canadine synthase
EC 1.14.19.69 biflaviolin synthase
EC 1.14.19.70 mycocyclosin synthase
EC 1.14.19.71 fumitremorgin C synthase
EC 1.14.19.72 (–)-pluviatolide synthase
EC 1.14.19.73 (S)-nandinine synthase
EC 1.14.19.74 (+)-piperitol/(+)-sesamin synthase
EC 1.14.19.75 very-long-chain acyl-lipid ω-9 desaturase
EC 1.14.19.76 flavone synthase II
EC 1.14.19.77 plasmanylethanolamine desaturase
EC 1.14.19.78 decanoyl-[acyl-carrier protein] acetylenase
EC 1.14.19.79 3β,22α-dihydroxysteroid 3-dehydrogenase
EC 1.14.19.80 (19E)-geissoschizine oxidase
EC 1.14.19.81 polyneuridine aldehyde synthase

EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

EC 1.14.20.1 deacetoxycephalosporin-C synthase
EC 1.14.20.2 now EC 1.14.11.59
EC 1.14.20.3 (5R)-carbapenem-3-carboxylate synthase
EC 1.14.20.4 anthocyanidin synthase
EC 1.14.20.5 flavone synthase I
EC 1.14.20.6 flavonol synthase
EC 1.14.20.7 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
EC 1.14.20.8 (–)-deoxypodophyllotoxin synthase
EC 1.14.20.9 L-tyrosine isonitrile desaturase
EC 1.14.20.10 L-tyrosine isonitrile desaturase/decarboxylase
EC 1.14.20.11 3-[(Z)-2-isocyanoethenyl]-1H-indole synthase
EC 1.14.20.12 3-[(E)-2-isocyanoethenyl]-1H-indole synthase
EC 1.14.20.13 6β-hydroxyhyoscyamine epoxidase
EC 1.14.20.14 hapalindole-type alkaloid chlorinase
EC 1.14.20.15 L-threonyl-[L-threonyl-carrier protein] 4-chlorinase
EC 1.14.20.16 4α,5β-5,20-epoxytax-11-ene-4,9-diol 9-dehydrogenase

EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated

EC 1.14.21.1 now EC 1.14.19.64
EC 1.14.21.2 now EC 1.14.19.65
EC 1.14.21.3 now EC 1.14.19.66
EC 1.14.21.4 now EC 1.14.19.67
EC 1.14.21.5 now EC 1.14.19.68
EC 1.14.21.6 now EC 1.14.19.20
EC 1.14.21.7 now EC 1.14.19.69
EC 1.14.21.8 now EC 1.14.19.63
EC 1.14.21.9 now EC 1.14.19.70
EC 1.14.21.10 now EC 1.14.19.71
EC 1.14.21.11 now EC 1.14.19.72
EC 1.14.21.12 now EC 1.14.19.73

EC 1.14.99 Miscellaneous

EC 1.14.99.1 prostaglandin-endoperoxide synthase
EC 1.14.99.2 kynurenine 7,8-hydroxylase
EC 1.14.99.3 now EC 1.14.14.18
EC 1.14.99.9 now EC 1.14.14.19
EC 1.14.99.4 progesterone monooxygenase
EC 1.14.99.5 now EC 1.14.19.1
EC 1.14.99.6 now EC 1.14.19.2
EC 1.14.99.7 now EC 1.14.13.132
EC 1.14.99.8 deleted, included in EC 1.14.14.1
EC 1.14.99.9 steroid 17α-monooxygenase
EC 1.14.99.10 now EC 1.14.14.16
EC 1.14.99.11 estradiol 6β-monooxygenase
EC 1.14.99.12 4-androstene-3,17-dione monooxygenase
EC 1.14.99.13 now EC 1.14.13.23
EC 1.14.99.14 progesterone 11α-monooxygenase
EC 1.14.99.15 4-methoxybenzoate monooxygenase (O-demethylating)
EC 1.14.99.16 now EC 1.14.13.72
EC 1.14.99.17 now EC 1.14.16.5
EC 1.14.99.18 deleted
EC 1.14.99.19 transferred now EC 1.14.19.77
EC 1.14.99.20 phylloquinone monooxygenase (2,3-epoxidizing)
EC 1.14.99.21 Latia-luciferin monooxygenase (demethylating)
EC 1.14.99.22 ecdysone 20-monooxygenase
EC 1.14.99.23 3-hydroxybenzoate 2-monooxygenase
EC 1.14.99.24 steroid 9α-monooxygenase
EC 1.14.99.25 now EC 1.14.19.3
EC 1.14.99.26 2-hydroxypyridine 5-monooxygenase
EC 1.14.99.27 now EC 1.17.3.4
EC 1.14.99.28 now EC 1.14.13.151
EC 1.14.99.29 deoxyhypusine monooxygenase
EC 1.14.99.30 now EC 1.3.5.6
EC 1.14.99.31 now EC 1.14.19.24
EC 1.14.99.32 now EC 1.14.19.5
EC 1.14.99.33 now EC 1.14.19.39
EC 1.14.99.34 monoprenyl isoflavone epoxidase
EC 1.14.99.35 thiophene-2-carbonyl-CoA monooxygenase
EC 1.14.99.36 now EC 1.13.11.63
EC 1.14.99.37 now EC 1.14.14.176
EC 1.14.99.38 cholesterol 25-hydroxylase
EC 1.14.99.39 ammonia monooxygenase
EC 1.14.99.40 now EC 1.13.11.79
EC 1.14.99.41 now EC 1.13.11.75
EC 1.14.99.42 now EC 1.13.11.84
EC 1.14.99.43 now EC 1.14.14.134
EC 1.14.99.44 diapolycopene oxygenase
EC 1.14.99.45 now EC 1.14.14.158
EC 1.14.99.46 pyrimidine oxygenase
EC 1.14.99.47 (+)-larreatricin hydroxylase
EC 1.14.99.48 heme oxygenase (staphylobilin-producing)
EC 1.14.99.49 now EC 1.14.15.31
EC 1.14.99.50 γ-glutamyl hercynylcysteine S-oxide synthase
EC 1.14.99.51 now EC 1.21.3.10
EC 1.14.99.52 L-cysteinyl-L-histidinylsulfoxide synthase
EC 1.14.99.53 lytic chitin monoxygenase
EC 1.14.99.54 lytic cellulose monooxygenase (C1-hydroxylating)
EC 1.14.99.55 lytic starch monooxygenase
EC 1.14.99.56 lytic cellulose monooxygenase (C4-dehydrogenating)
EC 1.14.99.57 heme oxygenase (mycobilin-producing)
EC 1.14.99.58 heme oxygenase (biliverdin-IX-β and δ-forming)
EC 1.14.99.59 tryptamine 4-monooxygenase
EC 1.14.99.60 3-demethoxyubiquinol 3-hydroxylase
EC 1.14.99.61 cyclooctat-9-en-7-ol 5-monooxygenase
EC 1.14.99.62 cyclooctatin synthase
EC 1.14.99.63 β-carotene 4-ketolase
EC 1.14.99.64 zeaxanthin 4-ketolase
EC 1.14.99.65 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase
EC 1.14.99.66 [histone-H3]-N⁶,N⁶-dimethyl-L-lysine⁴ FAD-dependent demethylase
EC 1.14.99.67 α-N-dichloroacetyl-p-aminophenylserinol N-oxygenase
EC 1.14.99.68 4-aminobenzoate N-oxygenase
EC 1.14.99.69 tRNA 2-(methylsulfanyl)-N⁶-isopentenyladenosine³⁷ hydroxylase

EC 1.15 Acting on superoxide as acceptor

EC 1.15.1.1 superoxide dismutase
EC 1.15.1.2 superoxide reductase

EC 1.16 Oxidizing metal ions

EC 1.16.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.16.1.1 mercury(II) reductase
EC 1.16.1.2 diferric-transferrin reductase
EC 1.16.1.3 deleted
EC 1.16.1.4 deleted
EC 1.16.1.5 deleted
EC 1.16.1.6 cyanocobalamin reductase
EC 1.16.1.7 ferric-chelate reductase (NADH)
EC 1.16.1.8 [methionine synthase] reductase
EC 1.16.1.9 ferric-chelate reductase (NADPH)
EC 1.16.1.10 ferric-chelate reductase [NAD(P)H]

EC 1.16.3 With oxygen as acceptor

EC 1.16.3.1 ferroxidase
EC 1.16.3.2 bacterial non-heme ferritin
EC 1.16.3.3 manganese oxidase
EC 1.16.3.4 cuproxidase

EC 1.16.5 With quinone or similar compound as acceptor

EC 1.16.5.1 transferred now EC 7.2.1.3

EC 1.16.8 With flavin as acceptor

EC 1.16.8.1 deleted, now known to be catalysed by EC 2.5.1.17
EC 1.16.9 With a copper protein as acceptor
EC 1.16.9.1 iron:rusticyanin reductase

EC 1.16.98 With other, known, physiological acceptor

EC 1.16.98.1 now EC 1.16.9.1

EC 1.16.99 With other, known, physiological acceptor

EC 1.16.99.1 [Co(II) methylated amine-specific corrinoid protein] reductase

EC 1.17 Acting on CH or CH₂ groups

EC 1.17.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.17.1.1 CDP-4-dehydro-6-deoxyglucose reductase
EC 1.17.1.2 now EC 1.17.7.4
EC 1.17.1.3 leucoanthocyanidin reductase
EC 1.17.1.4 now EC 1.2.1.91
EC 1.17.1.5 nicotinate dehydrogenase
EC 1.17.1.6 now EC 1.17.99.5
EC 1.17.1.7 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
EC 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase
EC 1.17.1.9 formate dehydrogenase
EC 1.17.1.10 formate dehydrogenase (NADP⁺)
EC 1.17.1.11 formate dehydrogenase (NAD⁺, ferredoxin)

EC 1.17.2 With a cytochrome as acceptor

EC 1.17.2.1 nicotinate dehydrogenase (cytochrome)
EC 1.17.2.2 lupanine 17-hydroxylase (cytochrome c)
EC 1.17.2.3 formate dehydrogenase (cytochrome-c-553)

EC 1.17.3 With oxygen as acceptor

EC 1.17.3.1 pteridine oxidase
EC 1.17.3.2 xanthine oxidase
EC 1.17.3.3 6-hydroxynicotinate dehydrogenase
EC 1.17.3.4 juglone 3-hydroxylase
EC 1.17.3.5 4-oxocyclohexanecarboxylate 2-dehydrogenase

EC 1.17.4 With a disulfide as acceptor

EC 1.17.4.1 ribonucleoside-diphosphate reductase
EC 1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)
EC 1.17.4.3 now EC 1.17.7.1
EC 1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)
EC 1.17.4.5 vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.17.5 With a quinone or similar compound as acceptor

EC 1.17.5.1 phenylacetyl-CoA dehydrogenase
EC 1.17.5.2 caffeine dehydrogenase
EC 1.17.5.3 formate dehydrogenase-N

EC 1.17.7 With an iron-sulfur protein as acceptor

EC 1.17.7.1 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
EC 1.17.7.2 7-hydroxymethyl chlorophyll a reductase
EC 1.17.7.3 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)
EC 1.17.7.4 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase

EC 1.17.8 With a flavin as acceptor

EC 1.17.8.1 hydroxysqualene dehydroxylase

EC 1.17.9 With a copper protein as acceptor

EC 1.17.9.1 4-methylphenol dehydrogenase (hydroxylating)
EC 1.17.9.2 (+)-pinoresinol hydroxylase

EC 1.17.98 With other, known, physiological acceptors

EC 1.17.98.1 deleted
EC 1.17.98.2 bacteriochlorophyllide c C-7¹-hydroxylase
EC 1.17.98.3 formate dehydrogenase (coenzyme F₄₂₀)
EC 1.17.98.4 formate dehydrogenase (hydrogenase)

EC 1.17.99 With unknown physiological acceptors

EC 1.17.99.1 now EC 1.17.9.1
EC 1.17.99.2 ethylbenzene hydroxylase
EC 1.17.99.3 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase
EC 1.17.99.4 uracil/thymine dehydrogenase
EC 1.17.99.5 now EC 1.17.98.1
EC 1.17.99.6 epoxyqueuosine reductase
EC 1.17.99.7 transferred now EC 1.17.98.4
EC 1.17.99.8 limonene dehydrogenase
EC 1.17.99.9 heme a synthase
EC 1.17.99.10 steroid C-25 hydroxylase
EC 1.17.99.11 3-oxo-Δ¹-steroid hydratase/dehydrogenase

EC 1.18 Acting on iron-sulfur proteins as donors

EC 1.18.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.18.1.1 rubredoxin—NAD⁺ reductase
EC 1.18.1.2 ferredoxin—NADP⁺ reductase
EC 1.18.1.3 ferredoxin—NAD⁺ reductase
EC 1.18.1.4 rubredoxin—NAD(P)⁺ reductase
EC 1.18.1.5 putidaredoxin—NAD⁺ reductase
EC 1.18.1.6 adrenodoxin-NADP⁺ reductase
EC 1.18.1.7 ferredoxin—NAD(P)⁺ reductase (naphthalene dioxygenase ferredoxin-specific)
EC 1.18.1.8 fnow EC 7.2.1.2

EC 1.18.2 With dinitrogen as acceptor (now EC 1.18.6)

EC 1.18.2.1 now EC 1.18.6.1

EC 1.18.3 With H⁺ as acceptor

EC 1.18.3.1 now EC 1.18.99.1

EC 1.18.6 With dinitrogen as acceptor

EC 1.18.6.1 nitrogenase
EC 1.18.6.2 vanadium-dependent nitrogenase

EC 1.18.96 With other, known, physiological acceptors

EC 1.18.96.1 now EC 1.15.1.2

EC 1.18.99 With H⁺ as acceptors

EC 1.18.99.1 now EC 1.12.7.2

EC 1.19 Acting on reduced flavodoxin as donor

EC 1.19.1 With NAD⁺ or NADP⁺ as acceptor
EC 1.19.1.1 flavodoxin—NADP⁺ reductase
EC 1.19.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.19.1.1 flavodoxin—NADP⁺ reductase

EC 1.19.6 With dinitrogen as acceptor

EC 1.19.6.1 nitrogenase (flavodoxin)

EC 1.20 Acting on phosphorus or arsenic in donors

EC 1.20.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.20.1.1 phosphonate dehydrogenase

EC 1.20.2 With a cytochrome as acceptor

EC 1.20.2.1 arsenate reductase (cytochrome c)

EC 1.20.4 Acting on phosphorus or arsenic in donors, with disulfide as acceptor

EC 1.20.4.1 arsenate reductase (glutathione/glutaredoxin)
EC 1.20.4.2 methylarsonate reductase
EC 1.20.4.3 mycoredoxin
EC 1.20.4.4 arsenate reductase (thioredoxin)

EC 1.20.9 With a copper protein as acceptor

EC 1.20.9.1 arsenate reductase (azurin)

EC 1.20.98 With other, known physiological acceptors

EC 1.20.98.1 now EC 1.20.9.1

EC 1.20.99 With unknown physiological acceptors

EC 1.20.99.1 arsenate reductase (donor)

EC 1.21 Acting on X-H and Y-H to form an X-Y bond

EC 1.21.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.21.1.1 iodotyrosine deiodinase
EC 1.21.1.2 2,4-dichlorobenzoyl-CoA reductase
EC 1.21.3 With oxygen as acceptor

EC 1.21.3.1 isopenicillin-N synthase
EC 1.21.3.2 columbamine oxidase
EC 1.21.3.3 reticuline oxidase
EC 1.21.3.4 sulochrin oxidase [(+)-bisdechlorogeodin-forming]
EC 1.21.3.5 sulochrin oxidase [(–)-bisdechlorogeodin-forming]
EC 1.21.3.6 aureusidin synthase
EC 1.21.3.7 tetrahydrocannabinolic acid synthase
EC 1.21.3.8 cannabidiolic acid synthase
EC 1.21.3.9 now EC 1.21.98.2
EC 1.21.3.10 hercynylcysteine S-oxide synthase
EC 1.21.3.11 precondylocarpine acetate synthase

EC 1.21.4 With a disulfide as acceptor

EC 1.21.4.1 D-proline reductase
EC 1.21.4.2 glycine reductase
EC 1.21.4.3 sarcosine reductase
EC 1.21.4.4 betaine reductase
EC 1.21.4.5 tetrachlorohydroquinone reductive dehalogenase

EC 1.21.98 With other, known, physiological acceptors

EC 1.21.98.1 cyclic dehypoxanthinyl futalosine synthase
EC 1.21.98.2 dichlorochromopyrrolate synthase
EC 1.21.98.3 anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
EC 1.21.98.4 PqqA peptide cyclase
EC 1.21.98.5 tetraether lipid synthase

EC 1.21.99 With unknown physiological acceptors

EC 1.21.99.1 β-cyclopiazonate dehydrogenase
EC 1.21.99.2 now EC 1.21.98.1
EC 1.21.99.3 thyroxine 5-deiodinase
EC 1.21.99.4 thyroxine 5'-deiodinase
EC 1.21.99.5 tetrachloroethene reductive dehalogenase

EC 1.22 Acting on halogen in donors

EC 1.22.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.22.1.1 now EC 1.21.1.1

EC 1.23 Reducing C-O-C group as acceptor

EC 1.23.1 With NADH or NADPH as donor

EC 1.23.1.1 (+)-pinoresinol reductase
EC 1.23.1.2 (+)-lariciresinol reductase
EC 1.23.1.3 (–)-pinoresinol reductase
EC 1.23.1.4 (–)-lariciresinol reductase

EC 1.23.5 With a quinone or related compound as acceptor

EC 1.23.5.1 violaxanthin de-epoxidase

EC 1.97 Other oxidoreductases

EC 1.97.1.1 chlorate reductase
EC 1.97.1.2 pyrogallol hydroxyltransferase
EC 1.97.1.3 now EC 1.12.98.4
EC 1.97.1.4 [formate-C-acetyltransferase]-activating enzyme
EC 1.97.1.5 now EC 1.20.4.1
EC 1.97.1.6 now EC 1.20.99.1
EC 1.97.1.7 now EC 1.20.4.2
EC 1.97.1.8 now EC 1.21.99.5
EC 1.97.1.9selenate reductase (cytochrome c)
EC 1.97.1.10 now EC 1.21.99.4
EC 1.97.1.11 now EC 1.21.99.3
EC 1.97.1.12 photosystem I
EC 1.97.1.13 aliphatic sulfonate oxidoreductase
EC 1.97.1.14 selenate reductase (quinol)
EC 1.97.1.15 2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate)

EC 1.98 Enzymes using H₂ as reductant

EC 1.98.1.1 now EC 1.18.99.1

EC 1.99 Other enzymes using O₂ as oxidant

EC 1.99.1 Hydroxylases (now EC 1.14)

EC 1.99.1.1 deleted, now EC 1.14.14.1
EC 1.99.1.2 deleted, now EC 1.14.16.1
EC 1.99.1.3 deleted
EC 1.99.1.4 deleted
EC 1.99.1.5 deleted, now EC 1.14.13.9
EC 1.99.1.6 deleted
EC 1.99.1.7 deleted, now EC 1.14.15.4
EC 1.99.1.8 deleted
EC 1.99.1.9 deleted, now EC 1.14.99.9
EC 1.99.1.10 deleted
EC 1.99.1.11 deleted, now EC 1.14.99.10
EC 1.99.1.12 deleted
EC 1.99.1.13 deleted, covered by EC 1.14.99.7 and EC 5.4.99.7
EC 1.99.1.14 deleted, now EC 1.13.11.27

EC 1.99.2 Oxygenases (now EC 1.13)

EC 1.99.2.1 deleted, now EC 1.13.11.12
EC 1.99.2.2 deleted, now EC 1.13.11.1
EC 1.99.2.3 deleted, now EC 1.13.11.3
EC 1.99.2.4 deleted, now EC 1.13.11.4
EC 1.99.2.5 deleted, now EC 1.13.11.5
EC 1.99.2.6 deleted, now EC 1.13.99.1

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